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{{Infobox_gene}}
{{GNF_Protein_box
'''Helicase SRCAP''' is an [[enzyme]] that in humans is encoded by the ''SRCAP'' [[gene]].<ref name="pmid10347196">{{cite journal | vauthors = Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J | title = Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein | journal = J Biol Chem | volume = 274 | issue = 23 | pages = 16370–6 |date=Jul 1999 | pmid = 10347196 | pmc =  | doi =10.1074/jbc.274.23.16370  }}</ref><ref name="pmid9205841">{{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 4 | issue = 2 | pages = 141–50 |date=Sep 1997 | pmid = 9205841 | pmc =  | doi =10.1093/dnares/4.2.141 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRCAP Snf2-related CBP activator protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10847| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = Snf2-related CBP activator protein
| HGNCid =
| Symbol = SRCAP
| AltSymbols =; KIAA0309
| OMIM =
| ECnumber =
| Homologene = 38213
| MGIid = 2444036
  | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10847
    | Hs_Ensembl = ENSG00000080603
    | Hs_RefseqProtein = NP_006653
    | Hs_RefseqmRNA = NM_006662
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 30617963
    | Hs_GenLoc_end = 30663100
    | Hs_Uniprot =
    | Mm_EntrezGene = 546001
    | Mm_Ensembl = ENSMUSG00000053877
    | Mm_RefseqmRNA = XM_486009
    | Mm_RefseqProtein = XP_486009
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 127303175
    | Mm_GenLoc_end = 127356414
    | Mm_Uniprot =   
  }}
}}
'''Snf2-related CBP activator protein''', also known as '''SRCAP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SRCAP Snf2-related CBP activator protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10847| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
*{{cite journal   |vauthors=Ghosh AK, Majumder M, Steele R, etal |title=Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7184–8 |year= 2000 |pmid= 10702287 |doi=10.1074/jbc.275.10.7184 }}
*{{cite journal  | author=Johnston H, Kneer J, Chackalaparampil I, ''et al.'' |title=Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16370-6 |year= 1999 |pmid= 10347196 |doi= }}
*{{cite journal   |vauthors=Xu X, Chackalaparampil I, Monroy MA, etal |title=Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. |journal=J. Virol. |volume=75 |issue= 21 |pages= 10033–40 |year= 2001 |pmid= 11581372 |doi= 10.1128/JVI.75.21.10033-10040.2001 | pmc=114578 }}
*{{cite journal | author=Ghosh AK, Majumder M, Steele R, ''et al.'' |title=Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7184-8 |year= 2000 |pmid= 10702287 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Xu X, Chackalaparampil I, Monroy MA, ''et al.'' |title=Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. |journal=J. Virol. |volume=75 |issue= 21 |pages= 10033-40 |year= 2001 |pmid= 11581372 |doi= 10.1128/JVI.75.21.10033-10040.2001 }}
*{{cite journal   |vauthors=Monroy MA, Schott NM, Cox L, etal |title=SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. |journal=Mol. Endocrinol. |volume=17 |issue= 12 |pages= 2519–28 |year= 2004 |pmid= 14500758 |doi= 10.1210/me.2003-0208 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Monroy MA, Schott NM, Cox L, ''et al.'' |title=SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. |journal=Mol. Endocrinol. |volume=17 |issue= 12 |pages= 2519-28 |year= 2004 |pmid= 14500758 |doi= 10.1210/me.2003-0208 }}
*{{cite journal   |vauthors=Cai Y, Jin J, Florens L, etal |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665–70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Eissenberg JC, Wong M, Chrivia JC |title=Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6559–69 |year= 2005 |pmid= 16024792 |doi= 10.1128/MCB.25.15.6559-6569.2005 | pmc=1190335 }}
*{{cite journal | author=Cai Y, Jin J, Florens L, ''et al.'' |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665-70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal  | author=Eissenberg JC, Wong M, Chrivia JC |title=Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6559-69 |year= 2005 |pmid= 16024792 |doi= 10.1128/MCB.25.15.6559-6569.2005 }}
*{{cite journal   |vauthors=Ruhl DD, Jin J, Cai Y, etal |title=Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. |journal=Biochemistry |volume=45 |issue= 17 |pages= 5671–7 |year= 2006 |pmid= 16634648 |doi= 10.1021/bi060043d }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Cai Y, Jin J, Gottschalk AJ, etal |title=Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. |journal=Methods |volume=40 |issue= 4 |pages= 312–7 |year= 2007 |pmid= 17101442 |doi= 10.1016/j.ymeth.2006.06.023 |pmc=3092633}}
*{{cite journal | author=Ruhl DD, Jin J, Cai Y, ''et al.'' |title=Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. |journal=Biochemistry |volume=45 |issue= 17 |pages= 5671-7 |year= 2006 |pmid= 16634648 |doi= 10.1021/bi060043d }}
*{{cite journal  | vauthors=Wong MM, Cox LK, Chrivia JC |title=The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26132–9 |year= 2007 |pmid= 17617668 |doi= 10.1074/jbc.M703418200 }}
*{{cite journal | author=Cai Y, Jin J, Gottschalk AJ, ''et al.'' |title=Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. |journal=Methods |volume=40 |issue= 4 |pages= 312-7 |year= 2007 |pmid= 17101442 |doi= 10.1016/j.ymeth.2006.06.023 }}
*{{cite journal  | author=Wong MM, Cox LK, Chrivia JC |title=The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26132-9 |year= 2007 |pmid= 17617668 |doi= 10.1074/jbc.M703418200 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [http://www.omim.org/search?index=entry&start=1&limit=10&sort=score+desc&search=number:(136140+OR+611421)  OMIM entry on Floating-Harbor syndrome and SRCAP]
 
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{{gene-16-stub}}

Latest revision as of 09:12, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.[1][2][3]


References

  1. ↑ Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem. 274 (23): 16370–6. doi:10.1074/jbc.274.23.16370. PMID 10347196.
  2. ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  3. ↑ "Entrez Gene: SRCAP Snf2-related CBP activator protein".

Further reading

External links



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