Metallothionein 1A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Metallothionein-1A''' is a [[protein]] that in humans is encoded by the ''MT1A'' [[gene]].<ref name="pmid6089206">{{cite journal |vauthors=Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB | title = Human metallothionein genes are clustered on chromosome 16 | journal = Proc Natl Acad Sci U S A | volume = 81 | issue = 17 | pages = 5494–8 |date=Oct 1984 | pmid = 6089206 | pmc = 391732 | doi =10.1073/pnas.81.17.5494 }}</ref><ref name="pmid6327055">{{cite journal |vauthors=Richards RI, Heguy A, Karin M | title = Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids | journal = Cell | volume = 37 | issue = 1 | pages = 263–72 |date=Jun 1984 | pmid = 6327055 | pmc =  | doi =10.1016/0092-8674(84)90322-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MT1A metallothionein 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4489| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_MT1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhu.
| PDB = {{PDB2|1mhu}}, {{PDB2|1mrb}}, {{PDB2|2mhu}}
| Name = Metallothionein 1A
| HGNCid = 7393
| Symbol = MT1A
| AltSymbols =; MGC32848; MT1; MT1S; MTC
| OMIM = 156350
| ECnumber =
| Homologene = 88733
| MGIid =   
| Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046870 |text = cadmium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4489
    | Hs_Ensembl = ENSG00000205362
    | Hs_RefseqProtein = NP_005937
    | Hs_RefseqmRNA = NM_005946
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 55230152
    | Hs_GenLoc_end = 55231363
    | Hs_Uniprot = P04731
    | Mm_EntrezGene =   
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Metallothionein 1A''', also known as '''MT1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MT1A metallothionein 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4489| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, ''et al.'' |title=Metallothionein: an overview. |journal=World J. Gastroenterol. |volume=13 |issue= 7 |pages= 993-6 |year= 2007 |pmid= 17373731 |doi=  }}
*{{cite journal   |vauthors=Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, etal |title=Metallothionein: an overview. |journal=World J. Gastroenterol. |volume=13 |issue= 7 |pages= 993–6 |year= 2007 |pmid= 17373731 |doi=  10.3748/wjg.v13.i7.993}}
*{{cite journal | author=Sutherland GR, Baker E, Callen DF, ''et al.'' |title=The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia. |journal=Genomics |volume=6 |issue= 1 |pages= 144-8 |year= 1990 |pmid= 2303255 |doi=  }}
*{{cite journal   |vauthors=Sutherland GR, Baker E, Callen DF, etal |title=The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia. |journal=Genomics |volume=6 |issue= 1 |pages= 144–8 |year= 1990 |pmid= 2303255 |doi=10.1016/0888-7543(90)90459-8 }}
*{{cite journal  | author=Grider A, Bailey LB, Cousins RJ |title=Erythrocyte metallothionein as an index of zinc status in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 4 |pages= 1259-62 |year= 1990 |pmid= 2304897 |doi=  }}
*{{cite journal  |vauthors=Grider A, Bailey LB, Cousins RJ |title=Erythrocyte metallothionein as an index of zinc status in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 4 |pages= 1259–62 |year= 1990 |pmid= 2304897 |doi=10.1073/pnas.87.4.1259  | pmc=53453 }}
*{{cite journal  | author=Le Beau MM, Diaz MO, Karin M, Rowley JD |title=Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. |journal=Nature |volume=313 |issue= 6004 |pages= 709-11 |year= 1985 |pmid= 3856101 |doi=  }}
*{{cite journal  |vauthors=Le Beau MM, Diaz MO, Karin M, Rowley JD |title=Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. |journal=Nature |volume=313 |issue= 6004 |pages= 709–11 |year= 1985 |pmid= 3856101 |doi=10.1038/313709a0 }}
*{{cite journal  | author=Hunziker PE, Kägi JH |title=Isolation and characterization of six human hepatic isometallothioneins. |journal=Biochem. J. |volume=231 |issue= 2 |pages= 375-82 |year= 1985 |pmid= 4062903 |doi=  }}
*{{cite journal  |vauthors=Hunziker PE, Kägi JH |title=Isolation and characterization of six human hepatic isometallothioneins. |journal=Biochem. J. |volume=231 |issue= 2 |pages= 375–82 |year= 1985 |pmid= 4062903 |doi=  | pmc=1152756 }}
*{{cite journal  | author=Karin M, Eddy RL, Henry WM, ''et al.'' |title=Human metallothionein genes are clustered on chromosome 16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5494-8 |year= 1984 |pmid= 6089206 |doi=  }}
*{{cite journal  |vauthors=Armitage IM, Otvos JD, Briggs RW, Boulanger Y |title=Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR. |journal=Fed. Proc. |volume=41 |issue= 13 |pages= 2974–80 |year= 1983 |pmid= 7140998 |doi=  }}
*{{cite journal  | author=Richards RI, Heguy A, Karin M |title=Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. |journal=Cell |volume=37 |issue= 1 |pages= 263-72 |year= 1984 |pmid= 6327055 |doi=  }}
*{{cite journal  |vauthors=Akintola DF, Sampson B, Fleck A |title=Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine. |journal=J. Lab. Clin. Med. |volume=126 |issue= 2 |pages= 119–27 |year= 1995 |pmid= 7543551 |doi=  }}
*{{cite journal  | author=Armitage IM, Otvos JD, Briggs RW, Boulanger Y |title=Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR. |journal=Fed. Proc. |volume=41 |issue= 13 |pages= 2974-80 |year= 1983 |pmid= 7140998 |doi=  }}
*{{cite journal  |vauthors=Davis SR, McMahon RJ, Cousins RJ |title=Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. |journal=J. Nutr. |volume=128 |issue= 5 |pages= 825–31 |year= 1998 |pmid= 9566988 |doi=  }}
*{{cite journal  | author=Akintola DF, Sampson B, Fleck A |title=Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine. |journal=J. Lab. Clin. Med. |volume=126 |issue= 2 |pages= 119-27 |year= 1995 |pmid= 7543551 |doi=  }}
*{{cite journal  |vauthors=Simpkins C, Lloyd T, Li S, Balderman S |title=Metallothionein-induced increase in mitochondrial inner membrane permeability. |journal=J. Surg. Res. |volume=75 |issue= 1 |pages= 30–4 |year= 1998 |pmid= 9614853 |doi= 10.1006/jsre.1997.5241 }}
*{{cite journal  | author=Davis SR, McMahon RJ, Cousins RJ |title=Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. |journal=J. Nutr. |volume=128 |issue= 5 |pages= 825-31 |year= 1998 |pmid= 9566988 |doi=  }}
*{{cite journal  |vauthors=Lau JC, Cherian MG |title=Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. |journal=Biochem. Cell Biol. |volume=76 |issue= 4 |pages= 615–23 |year= 1999 |pmid= 10099782 |doi=10.1139/bcb-76-4-615 }}
*{{cite journal  | author=Simpkins C, Lloyd T, Li S, Balderman S |title=Metallothionein-induced increase in mitochondrial inner membrane permeability. |journal=J. Surg. Res. |volume=75 |issue= 1 |pages= 30-4 |year= 1998 |pmid= 9614853 |doi= 10.1006/jsre.1997.5241 }}
*{{cite journal   |vauthors=Levadoux M, Mahon C, Beattie JH, etal |title=Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34961–6 |year= 2000 |pmid= 10574972 |doi=10.1074/jbc.274.49.34961 }}
*{{cite journal  | author=Lau JC, Cherian MG |title=Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. |journal=Biochem. Cell Biol. |volume=76 |issue= 4 |pages= 615-23 |year= 1999 |pmid= 10099782 |doi=  }}
*{{cite journal   |vauthors=Garrett SH, Sens MA, Shukla D, etal |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. |journal=Prostate |volume=43 |issue= 2 |pages= 125–35 |year= 2000 |pmid= 10754528 |doi=10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S }}
*{{cite journal | author=Levadoux M, Mahon C, Beattie JH, ''et al.'' |title=Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34961-6 |year= 2000 |pmid= 10574972 |doi=  }}
*{{cite journal  |vauthors=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419–33 |year= 2000 |pmid= 10774930 |doi=  }}
*{{cite journal | author=Garrett SH, Sens MA, Shukla D, ''et al.'' |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. |journal=Prostate |volume=43 |issue= 2 |pages= 125-35 |year= 2000 |pmid= 10754528 |doi=  }}
*{{cite journal   |vauthors=Campagne MV, Thibodeaux H, van Bruggen N, etal |title=Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. |journal=J. Neurosci. |volume=20 |issue= 14 |pages= 5200–7 |year= 2000 |pmid= 10884303 |doi=  }}
*{{cite journal  | author=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419-33 |year= 2000 |pmid= 10774930 |doi=  }}
*{{cite journal  |vauthors=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood. |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849–56 |year= 2001 |pmid= 11168427 |doi=10.1046/j.1432-1327.2001.01947.x }}
*{{cite journal | author=Campagne MV, Thibodeaux H, van Bruggen N, ''et al.'' |title=Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. |journal=J. Neurosci. |volume=20 |issue= 14 |pages= 5200-7 |year= 2000 |pmid= 10884303 |doi=  }}
*{{cite journal  |vauthors=Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM |title=Influence of metallothionein-1 localization on its function. |journal=Biochem. J. |volume=355 |issue= Pt 2 |pages= 473–9 |year= 2001 |pmid= 11284736 |doi=10.1042/0264-6021:3550473  | pmc=1221760 }}
*{{cite journal  | author=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood. |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849-56 |year= 2001 |pmid= 11168427 |doi=  }}
*{{cite journal  |vauthors=Richarz AN, Brätter P |title=Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins. |journal=Analytical and Bioanalytical Chemistry |volume=372 |issue= 3 |pages= 412–7 |year= 2002 |pmid= 11939525 |doi= 10.1007/s00216-001-1187-5 }}
*{{cite journal  | author=Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM |title=Influence of metallothionein-1 localization on its function. |journal=Biochem. J. |volume=355 |issue= Pt 2 |pages= 473-9 |year= 2001 |pmid= 11284736 |doi=  }}
*{{cite journal  |vauthors=Minami T, Kubo K, Ichida S |title=Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH. |journal=J. Chromatogr. B |volume=779 |issue= 2 |pages= 211–9 |year= 2003 |pmid= 12361735 |doi=  10.1016/S1570-0232(02)00375-6}}
*{{cite journal  | author=Richarz AN, Brätter P |title=Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins. |journal=Analytical and bioanalytical chemistry |volume=372 |issue= 3 |pages= 412-7 |year= 2002 |pmid= 11939525 |doi= 10.1007/s00216-001-1187-5 }}
*{{cite journal  | author=Minami T, Kubo K, Ichida S |title=Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH. |journal=J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |volume=779 |issue= 2 |pages= 211-9 |year= 2003 |pmid= 12361735 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4489}}
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[[Category:Human proteins]]


{{protein-stub}}
{{gene-16-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:13, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Metallothionein-1A is a protein that in humans is encoded by the MT1A gene.[1][2][3]

References

  1. ↑ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
  2. ↑ Richards RI, Heguy A, Karin M (Jun 1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids". Cell. 37 (1): 263–72. doi:10.1016/0092-8674(84)90322-2. PMID 6327055.
  3. ↑ "Entrez Gene: MT1A metallothionein 1A".

Further reading

  • Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: an overview". World J. Gastroenterol. 13 (7): 993–6. doi:10.3748/wjg.v13.i7.993. PMID 17373731.
  • Sutherland GR, Baker E, Callen DF, et al. (1990). "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia". Genomics. 6 (1): 144–8. doi:10.1016/0888-7543(90)90459-8. PMID 2303255.
  • Grider A, Bailey LB, Cousins RJ (1990). "Erythrocyte metallothionein as an index of zinc status in humans". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1259–62. doi:10.1073/pnas.87.4.1259. PMC 53453. PMID 2304897.
  • Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia". Nature. 313 (6004): 709–11. doi:10.1038/313709a0. PMID 3856101.
  • Hunziker PE, Kägi JH (1985). "Isolation and characterization of six human hepatic isometallothioneins". Biochem. J. 231 (2): 375–82. PMC 1152756. PMID 4062903.
  • Armitage IM, Otvos JD, Briggs RW, Boulanger Y (1983). "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR". Fed. Proc. 41 (13): 2974–80. PMID 7140998.
  • Akintola DF, Sampson B, Fleck A (1995). "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine". J. Lab. Clin. Med. 126 (2): 119–27. PMID 7543551.
  • Davis SR, McMahon RJ, Cousins RJ (1998). "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression". J. Nutr. 128 (5): 825–31. PMID 9566988.
  • Simpkins C, Lloyd T, Li S, Balderman S (1998). "Metallothionein-induced increase in mitochondrial inner membrane permeability". J. Surg. Res. 75 (1): 30–4. doi:10.1006/jsre.1997.5241. PMID 9614853.
  • Lau JC, Cherian MG (1999). "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice". Biochem. Cell Biol. 76 (4): 615–23. doi:10.1139/bcb-76-4-615. PMID 10099782.
  • Levadoux M, Mahon C, Beattie JH, et al. (2000). "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton". J. Biol. Chem. 274 (49): 34961–6. doi:10.1074/jbc.274.49.34961. PMID 10574972.
  • Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528.
  • Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
  • Campagne MV, Thibodeaux H, van Bruggen N, et al. (2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion". J. Neurosci. 20 (14): 5200–7. PMID 10884303.
  • Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". Eur. J. Biochem. 268 (3): 849–56. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427.
  • Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM (2001). "Influence of metallothionein-1 localization on its function". Biochem. J. 355 (Pt 2): 473–9. doi:10.1042/0264-6021:3550473. PMC 1221760. PMID 11284736.
  • Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins". Analytical and Bioanalytical Chemistry. 372 (3): 412–7. doi:10.1007/s00216-001-1187-5. PMID 11939525.
  • Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH". J. Chromatogr. B. 779 (2): 211–9. doi:10.1016/S1570-0232(02)00375-6. PMID 12361735.


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