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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Metallothionein-1F''' is a [[protein]] that in humans is encoded by the ''MT1F'' [[gene]].<ref name="pmid6089206">{{cite journal |vauthors=Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB | title = Human metallothionein genes are clustered on chromosome 16 | journal = Proc Natl Acad Sci U S A | volume = 81 | issue = 17 | pages = 5494–8 |date=Oct 1984 | pmid = 6089206 | pmc = 391732 | doi =10.1073/pnas.81.17.5494 }}</ref><ref name="pmid2581970">{{cite journal |vauthors=Schmidt CJ, Jubier MF, Hamer DH | title = Structure and expression of two human metallothionein-I isoform genes and a related pseudogene | journal = J Biol Chem | volume = 260 | issue = 12 | pages = 7731–7 |date=Jul 1985 | pmid = 2581970 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MT1F metallothionein 1F| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4494| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_MT1F_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dfs.
| PDB = {{PDB2|1dfs}}, {{PDB2|1mhu}}, {{PDB2|2mhu}}
| Name = Metallothionein 1F
| HGNCid = 7398
| Symbol = MT1F
| AltSymbols =; MT1; MGC32732
| OMIM = 156352
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_MT1F_210524_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_MT1F_213629_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_MT1F_217165_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046870 |text = cadmium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4494
    | Hs_Ensembl = ENSG00000198417
    | Hs_RefseqProtein = NP_005940
    | Hs_RefseqmRNA = NM_005949
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 55249356
    | Hs_GenLoc_end = 55250713
    | Hs_Uniprot = P04733
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
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    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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'''Metallothionein 1F''', also known as '''MT1F''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MT1F metallothionein 1F| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4494| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=West AK, Stallings R, Hildebrand CE, ''et al.'' |title=Human metallothionein genes: structure of the functional locus at 16q13. |journal=Genomics |volume=8 |issue= 3 |pages= 513-8 |year= 1991 |pmid= 2286373 |doi= }}
*{{cite journal |vauthors=West AK, Stallings R, Hildebrand CE, etal |title=Human metallothionein genes: structure of the functional locus at 16q13 |journal=Genomics |volume=8 |issue= 3 |pages= 513–8 |year= 1991 |pmid= 2286373 |doi=10.1016/0888-7543(90)90038-V }}
*{{cite journal  | author=Gedamu L, Varshney U, Jahroudi N, ''et al.'' |title=Structure and expression of the human metallothionein genes. |journal=Experientia Suppl. |volume=52 |issue= |pages= 361-72 |year= 1987 |pmid= 2444457 |doi= }}
*{{Cite book |vauthors=Gedamu L, Varshney U, Jahroudi N, etal |title=Structure and expression of the human metallothionein genes |journal=Experientia. Supplementum |volume=52 |issue= |pages= 361–72 |year= 1987 |pmid= 2444457 |doi= 10.1007/978-3-0348-6784-9_34|series=Experientia Supplementum |isbn=978-3-0348-6786-3 }}
*{{cite journal  | author=Schmidt CJ, Jubier MF, Hamer DH |title=Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. |journal=J. Biol. Chem. |volume=260 |issue= 12 |pages= 7731-7 |year= 1985 |pmid= 2581970 |doi=  }}
*{{cite journal |vauthors=Varshney U, Jahroudi N, Foster R, Gedamu L |title=Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 26–37 |year= 1987 |pmid= 3023827 |doi= | pmc=367480 }}
*{{cite journal | author=Varshney U, Jahroudi N, Foster R, Gedamu L |title=Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 26-37 |year= 1987 |pmid= 3023827 |doi= }}
*{{cite journal |vauthors=Foster R, Jahroudi N, Varshney U, Gedamu L |title=Structure and expression of the human metallothionein-IG gene Differential promoter activity of two linked metallothionein-I genes in response to heavy metals |journal=J. Biol. Chem. |volume=263 |issue= 23 |pages= 11528–35 |year= 1988 |pmid= 3403543 |doi= }}
*{{cite journal | author=Foster R, Jahroudi N, Varshney U, Gedamu L |title=Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. |journal=J. Biol. Chem. |volume=263 |issue= 23 |pages= 11528-35 |year= 1988 |pmid= 3403543 |doi= }}
*{{cite journal |vauthors=Carter AD, Felber BK, Walling MJ, etal |title=Duplicated heavy metal control sequences of the mouse metallothionein-I gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 23 |pages= 7392–6 |year= 1985 |pmid= 6095291 |doi=10.1073/pnas.81.23.7392 | pmc=392152 }}
*{{cite journal | author=Karin M, Eddy RL, Henry WM, ''et al.'' |title=Human metallothionein genes are clustered on chromosome 16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5494-8 |year= 1984 |pmid= 6089206 |doi=  }}
*{{cite journal |vauthors=Bylander JE, Li SL, Sens MA, Sens DA |title=Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA |journal=Toxicol. Lett. |volume=76 |issue= 3 |pages= 209–17 |year= 1995 |pmid= 7762008 |doi=10.1016/0378-4274(95)80005-X }}
*{{cite journal  | author=Carter AD, Felber BK, Walling MJ, ''et al.'' |title=Duplicated heavy metal control sequences of the mouse metallothionein-I gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 23 |pages= 7392-6 |year= 1985 |pmid= 6095291 |doi= }}
*{{cite journal |vauthors=Mididoddi S, McGuirt JP, Sens MA, etal |title=Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney |journal=Toxicol. Lett. |volume=85 |issue= 1 |pages= 17–27 |year= 1996 |pmid= 8619255 |doi=10.1016/0378-4274(96)03632-6 }}
*{{cite journal | author=Bylander JE, Li SL, Sens MA, Sens DA |title=Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA. |journal=Toxicol. Lett. |volume=76 |issue= 3 |pages= 209-17 |year= 1995 |pmid= 7762008 |doi= }}
*{{cite journal |vauthors=Garrett SH, Somji S, Todd JH, etal |title=Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals |journal=Environ. Health Perspect. |volume=106 |issue= 12 |pages= 825–32 |year= 1999 |pmid= 9831543 |doi=10.2307/3434126 | pmc=1533231 | jstor=3434126}}
*{{cite journal | author=Mididoddi S, McGuirt JP, Sens MA, ''et al.'' |title=Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. |journal=Toxicol. Lett. |volume=85 |issue= 1 |pages= 17-27 |year= 1996 |pmid= 8619255 |doi= }}
*{{cite journal |vauthors=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419–33 |year= 2000 |pmid= 10774930 |doi= }}
*{{cite journal | author=Garrett SH, Somji S, Todd JH, ''et al.'' |title=Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. |journal=Environ. Health Perspect. |volume=106 |issue= 12 |pages= 825-32 |year= 1999 |pmid= 9831543 |doi= }}
*{{cite journal |vauthors=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849–56 |year= 2001 |pmid= 11168427 |doi=10.1046/j.1432-1327.2001.01947.x }}
*{{cite journal | author=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419-33 |year= 2000 |pmid= 10774930 |doi= }}
*{{cite journal |vauthors=Jin R, Bay BH, Chow VT, etal |title=Significance of metallothionein expression in breast myoepithelial cells |journal=Cell Tissue Res. |volume=303 |issue= 2 |pages= 221–6 |year= 2001 |pmid= 11291768 |doi=10.1007/s004410000310 }}
*{{cite journal | author=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood. |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849-56 |year= 2001 |pmid= 11168427 |doi= }}
*{{cite journal |vauthors=Garrett SH, Belcastro M, Sens MA, etal |title=Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells |journal=J. Toxicol. Environ. Health Part A |volume=64 |issue= 4 |pages= 343–55 |year= 2001 |pmid= 11693492 |doi=10.1080/152873901316981321 }}
*{{cite journal | author=Jin R, Bay BH, Chow VT, ''et al.'' |title=Significance of metallothionein expression in breast myoepithelial cells. |journal=Cell Tissue Res. |volume=303 |issue= 2 |pages= 221-6 |year= 2001 |pmid= 11291768 |doi= }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Garrett SH, Belcastro M, Sens MA, ''et al.'' |title=Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. |journal=J. Toxicol. Environ. Health Part A |volume=64 |issue= 4 |pages= 343-55 |year= 2001 |pmid= 11693492 |doi= }}
*{{cite journal |vauthors=Izmailova E, Bertley FM, Huang Q, etal |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Lu DD, Chen YC, Zhang XR, etal |title=The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma |journal=The Yale Journal of Biology and Medicine |volume=76 |issue= 2 |pages= 55–62 |year= 2005 |pmid= 15369632 |doi= | pmc=2582696 }}
*{{cite journal | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Lu DD, Chen YC, Zhang XR, ''et al.'' |title=The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma. |journal=The Yale journal of biology and medicine |volume=76 |issue= 2 |pages= 55-62 |year= 2005 |pmid= 15369632 |doi= }}
*{{cite journal |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1–3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203-8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4494}}
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Latest revision as of 09:17, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Metallothionein-1F is a protein that in humans is encoded by the MT1F gene.[1][2][3]

References

  1. ↑ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
  2. ↑ Schmidt CJ, Jubier MF, Hamer DH (Jul 1985). "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene". J Biol Chem. 260 (12): 7731–7. PMID 2581970.
  3. ↑ "Entrez Gene: MT1F metallothionein 1F".

Further reading



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