Metallothionein 1G: Difference between revisions

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{{Infobox_gene}}
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'''Metallothionein-1G''' is a [[protein]] that in humans is encoded by the ''MT1G'' [[gene]].<ref name="pmid3403543">{{cite journal |vauthors=Foster R, Jahroudi N, Varshney U, Gedamu L | title = Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals | journal = J Biol Chem | volume = 263 | issue = 23 | pages = 11528–35 |date=Sep 1988 | pmid = 3403543 | pmc =  | doi =  }}</ref><ref name="pmid6089206">{{cite journal |vauthors=Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB | title = Human metallothionein genes are clustered on chromosome 16 | journal = Proc Natl Acad Sci U S A | volume = 81 | issue = 17 | pages = 5494–8 |date=Oct 1984 | pmid = 6089206 | pmc = 391732 | doi =10.1073/pnas.81.17.5494 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MT1G metallothionein 1G| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4495| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_MT1G_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhu.
| PDB = {{PDB2|1mhu}}, {{PDB2|1mrb}}, {{PDB2|1mrt}}, {{PDB2|2mhu}}
| Name = Metallothionein 1G
| HGNCid = 7399
| Symbol = MT1G
| AltSymbols =; MT1; MGC12386; MT1K
| OMIM = 156353
| ECnumber =
| Homologene = 87857
| MGIid =
  | GeneAtlas_image1 = PBB_GE_MT1G_204745_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046870 |text = cadmium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4495
    | Hs_Ensembl = ENSG00000125144
    | Hs_RefseqProtein = NP_005941
    | Hs_RefseqmRNA = NM_005950
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 55258149
    | Hs_GenLoc_end = 55259478
    | Hs_Uniprot = P80295
    | Mm_EntrezGene =
    | Mm_Ensembl =
    | Mm_RefseqmRNA =
    | Mm_RefseqProtein =
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Metallothionein 1G''', also known as '''MT1G''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MT1G metallothionein 1G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4495| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=West AK, Stallings R, Hildebrand CE, ''et al.'' |title=Human metallothionein genes: structure of the functional locus at 16q13. |journal=Genomics |volume=8 |issue= 3 |pages= 513-8 |year= 1991 |pmid= 2286373 |doi= }}
*{{cite journal |vauthors=West AK, Stallings R, Hildebrand CE, etal |title=Human metallothionein genes: structure of the functional locus at 16q13 |journal=Genomics |volume=8 |issue= 3 |pages= 513–8 |year= 1991 |pmid= 2286373 |doi=10.1016/0888-7543(90)90038-V }}
*{{cite journal  | author=Gedamu L, Varshney U, Jahroudi N, ''et al.'' |title=Structure and expression of the human metallothionein genes. |journal=Experientia Suppl. |volume=52 |issue= |pages= 361-72 |year= 1987 |pmid= 2444457 |doi= }}
*{{Cite book |vauthors=Gedamu L, Varshney U, Jahroudi N, etal |title=Structure and expression of the human metallothionein genes |journal=Experientia. Supplementum |volume=52 |issue= |pages= 361–72 |year= 1987 |pmid= 2444457 |doi= 10.1007/978-3-0348-6784-9_34|series=Experientia Supplementum |isbn=978-3-0348-6786-3 }}
*{{cite journal | author=Varshney U, Jahroudi N, Foster R, Gedamu L |title=Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 26-37 |year= 1987 |pmid= 3023827 |doi= }}
*{{cite journal |vauthors=Varshney U, Jahroudi N, Foster R, Gedamu L |title=Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 26–37 |year= 1987 |pmid= 3023827 |doi= | pmc=367480 }}
*{{cite journal  | author=Foster R, Jahroudi N, Varshney U, Gedamu L |title=Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. |journal=J. Biol. Chem. |volume=263 |issue= 23 |pages= 11528-35 |year= 1988 |pmid= 3403543 |doi=  }}
*{{cite journal |vauthors=Pauwels M, van Weyenbergh J, Soumillion A, etal |title=Induction by zinc of specific metallothionein isoforms in human monocytes |journal=Eur. J. Biochem. |volume=220 |issue= 1 |pages= 105–10 |year= 1994 |pmid= 8119276 |doi=10.1111/j.1432-1033.1994.tb18603.x }}
*{{cite journal | author=Karin M, Eddy RL, Henry WM, ''et al.'' |title=Human metallothionein genes are clustered on chromosome 16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5494-8 |year= 1984 |pmid= 6089206 |doi=  }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Pauwels M, van Weyenbergh J, Soumillion A, ''et al.'' |title=Induction by zinc of specific metallothionein isoforms in human monocytes. |journal=Eur. J. Biochem. |volume=220 |issue= 1 |pages= 105-10 |year= 1994 |pmid= 8119276 |doi= }}
*{{cite journal |vauthors=Izmailova E, Bertley FM, Huang Q, etal |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Huang Y, de la Chapelle A, Pellegata NS |title=Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |journal=Int. J. Cancer |volume=104 |issue= 6 |pages= 735–44 |year= 2003 |pmid= 12640681 |doi= 10.1002/ijc.11006 }}
*{{cite journal | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal |vauthors=Cui YP, Wang JB, Zhang XY, etal |title=Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene |journal=World J. Gastroenterol. |volume=9 |issue= 9 |pages= 1892–6 |year= 2003 |pmid= 12970870 |pmc=4656638 |doi= 10.3748/wjg.v9.i9.1892}}
*{{cite journal | author=Huang Y, de la Chapelle A, Pellegata NS |title=Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |journal=Int. J. Cancer |volume=104 |issue= 6 |pages= 735-44 |year= 2003 |pmid= 12640681 |doi= 10.1002/ijc.11006 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Cui YP, Wang JB, Zhang XY, ''et al.'' |title=Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. |journal=World J. Gastroenterol. |volume=9 |issue= 9 |pages= 1892-6 |year= 2003 |pmid= 12970870 |doi= }}
*{{cite journal |vauthors=Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S |title=Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors |journal=Oncogene |volume=24 |issue= 13 |pages= 2204–17 |year= 2005 |pmid= 15735762 |doi= 10.1038/sj.onc.1208206 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal |vauthors=Sun NN, Fastje CD, Wong SS, etal |title=Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line |journal=Toxicology and Industrial Health |volume=19 |issue= 7–10 |pages= 157–63 |year= 2005 |pmid= 15747776 |doi=10.1191/0748233703th185oa }}
*{{cite journal | author=Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S |title=Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. |journal=Oncogene |volume=24 |issue= 13 |pages= 2204-17 |year= 2005 |pmid= 15735762 |doi= 10.1038/sj.onc.1208206 }}
*{{cite journal |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1–3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
*{{cite journal | author=Sun NN, Fastje CD, Wong SS, ''et al.'' |title=Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. |journal=Toxicology and industrial health |volume=19 |issue= 7-10 |pages= 157-63 |year= 2005 |pmid= 15747776 |doi= }}
*{{cite journal | author=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203-8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4495}}
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[[Category:Human proteins]]


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Latest revision as of 09:18, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Metallothionein-1G is a protein that in humans is encoded by the MT1G gene.[1][2][3]


References

  1. ↑ Foster R, Jahroudi N, Varshney U, Gedamu L (Sep 1988). "Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals". J Biol Chem. 263 (23): 11528–35. PMID 3403543.
  2. ↑ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
  3. ↑ "Entrez Gene: MT1G metallothionein 1G".

Further reading


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