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{{Infobox_gene}}
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'''[[Katanin]] p80 WD40-containing subunit B1''' is a [[protein]] that in humans is encoded by the ''KATNB1'' [[gene]].<ref name="pmid9568719">{{cite journal |vauthors=Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ | title = Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit | journal = Cell | volume = 93 | issue = 2 | pages = 277–87 |date=May 1998 | pmid = 9568719 | pmc =  | doi =10.1016/S0092-8674(00)81578-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10300| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Katanin p80 (WD repeat containing) subunit B 1
| HGNCid = 6217
| Symbol = KATNB1
| AltSymbols =; KAT
| OMIM = 602703
| ECnumber = 
| Homologene = 4302
| MGIid = 1921437
| GeneAtlas_image1 = PBB_GE_KATNB1_203162_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KATNB1_203163_at_tn.png
| Function = {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0008568 |text = microtubule-severing ATPase activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0008352 |text = katanin complex}}
  | Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0007026 |text = negative regulation of microtubule depolymerization}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0031117 |text = positive regulation of microtubule depolymerization}} {{GNF_GO|id=GO:0051301 |text = cell division}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10300
    | Hs_Ensembl = ENSG00000140854
    | Hs_RefseqProtein = NP_005877
    | Hs_RefseqmRNA = NM_005886
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 56328618
    | Hs_GenLoc_end = 56348657
    | Hs_Uniprot = Q9BVA0
    | Mm_EntrezGene = 74187
    | Mm_Ensembl = ENSMUSG00000031787
    | Mm_RefseqmRNA = NM_028805
    | Mm_RefseqProtein = NP_083081
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 97970330
    | Mm_GenLoc_end = 97989003
    | Mm_Uniprot = Q8BG40
  }}
}}
'''Katanin p80 (WD repeat containing) subunit B 1''', also known as '''KATNB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10300| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.<ref name="entrez">{{cite web | title = Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10300| accessdate = }}</ref>
| summary_text = Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.<ref name="entrez">{{cite web | title = Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10300| accessdate = }}</ref>
}}
}}. KATNB1 is associated with [[microlissencephaly]].


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Toyo-Oka K, Sasaki S, Yano Y, ''et al.'' |title=Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. |journal=Hum. Mol. Genet. |volume=14 |issue= 21 |pages= 3113-28 |year= 2006 |pmid= 16203747 |doi= 10.1093/hmg/ddi339 }}
*{{cite journal   |vauthors=Toyo-Oka K, Sasaki S, Yano Y, etal |title=Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. |journal=Hum. Mol. Genet. |volume=14 |issue= 21 |pages= 3113–28 |year= 2006 |pmid= 16203747 |doi= 10.1093/hmg/ddi339 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Karabay A, Yu W, Solowska JM, ''et al.'' |title=Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. |journal=J. Neurosci. |volume=24 |issue= 25 |pages= 5778-88 |year= 2004 |pmid= 15215300 |doi= 10.1523/JNEUROSCI.1382-04.2004 }}
*{{cite journal   |vauthors=Karabay A, Yu W, Solowska JM, etal |title=Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. |journal=J. Neurosci. |volume=24 |issue= 25 |pages= 5778–88 |year= 2004 |pmid= 15215300 |doi= 10.1523/JNEUROSCI.1382-04.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=McNally KP, Bazirgan OA, McNally FJ |title=Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. |journal=J. Cell. Sci. |volume=113 ( Pt 9) |issue=  |pages= 1623-33 |year= 2000 |pmid= 10751153 |doi=  }}
*{{cite journal  |vauthors=McNally KP, Bazirgan OA, McNally FJ |title=Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. |journal=J. Cell Sci. |volume=113 |issue=  9|pages= 1623–33 |year= 2000 |pmid= 10751153 |doi=  }}
*{{cite journal  | author=Ahmad FJ, Yu W, McNally FJ, Baas PW |title=An essential role for katanin in severing microtubules in the neuron. |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 305-15 |year= 1999 |pmid= 10209026 |doi=  }}
*{{cite journal  |vauthors=Ahmad FJ, Yu W, McNally FJ, Baas PW |title=An essential role for katanin in severing microtubules in the neuron. |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 305–15 |year= 1999 |pmid= 10209026 |doi=10.1083/jcb.145.2.305  | pmc=2133110 }}
*{{cite journal  | author=McNally FJ, Thomas S |title=Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. |journal=Mol. Biol. Cell |volume=9 |issue= 7 |pages= 1847-61 |year= 1999 |pmid= 9658175 |doi=  }}
*{{cite journal  |vauthors=McNally FJ, Thomas S |title=Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. |journal=Mol. Biol. Cell |volume=9 |issue= 7 |pages= 1847–61 |year= 1999 |pmid= 9658175 |doi=  10.1091/mbc.9.7.1847| pmc=25426 }}
*{{cite journal  | author=Hartman JJ, Mahr J, McNally K, ''et al.'' |title=Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. |journal=Cell |volume=93 |issue= 2 |pages= 277-87 |year= 1998 |pmid= 9568719 |doi=  }}
*{{cite journal  |vauthors=McNally FJ, Okawa K, Iwamatsu A, Vale RD |title=Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. |journal=J. Cell Sci. |volume=109 |issue=  3|pages= 561–7 |year= 1997 |pmid= 8907702 |doi=  }}
*{{cite journal  | author=McNally FJ, Okawa K, Iwamatsu A, Vale RD |title=Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. |journal=J. Cell. Sci. |volume=109 ( Pt 3) |issue=  |pages= 561-7 |year= 1997 |pmid= 8907702 |doi=  }}
*{{cite journal  |vauthors=McNally FJ, Vale RD |title=Identification of katanin, an ATPase that severs and disassembles stable microtubules. |journal=Cell |volume=75 |issue= 3 |pages= 419–29 |year= 1993 |pmid= 8221885 |doi=10.1016/0092-8674(93)90377-3 }}
*{{cite journal  | author=McNally FJ, Vale RD |title=Identification of katanin, an ATPase that severs and disassembles stable microtubules. |journal=Cell |volume=75 |issue= 3 |pages= 419-29 |year= 1993 |pmid= 8221885 |doi=  }}
*{{cite journal  |vauthors=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW |title=Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. |journal=Mol. Cell. Biol. |volume=3 |issue= 10 |pages= 1738–45 |year= 1984 |pmid= 6646120 |doi= 10.1128/mcb.3.10.1738| pmc=370035 }}
*{{cite journal  | author=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW |title=Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. |journal=Mol. Cell. Biol. |volume=3 |issue= 10 |pages= 1738-45 |year= 1984 |pmid= 6646120 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|KATNB1}}
* {{UCSC gene details|KATNB1}}
 
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Latest revision as of 09:18, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.[1][2]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.[2]. KATNB1 is associated with microlissencephaly.

References

  1. ↑ Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
  2. ↑ 2.0 2.1 "Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1".

Further reading

External links



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