CNTNAP4: Difference between revisions
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'''Contactin-associated protein-like 4''' is a [[protein]] that in humans is encoded by the ''CNTNAP4'' [[gene]].<ref name="pmid12093160">{{cite journal | vauthors = Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E | title = Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains | journal = Mol Cell Neurosci | volume = 20 | issue = 2 | pages = 283–97 |date=Jul 2002 | pmid = 12093160 | pmc = | doi =10.1006/mcne.2002.1110 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNTNAP4 contactin associated protein-like 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85445| accessdate = }}</ref> | '''Contactin-associated protein-like 4''' is a [[protein]] that in humans is encoded by the ''CNTNAP4'' [[gene]].<ref name="pmid12093160">{{cite journal | vauthors = Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E | title = Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains | journal = Mol Cell Neurosci | volume = 20 | issue = 2 | pages = 283–97 |date=Jul 2002 | pmid = 12093160 | pmc = | doi =10.1006/mcne.2002.1110 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNTNAP4 contactin associated protein-like 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85445| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez" /> | | summary_text = This [[gene product]] belongs to the [[neurexin]] family, members of which function in the vertebrate [[nervous system]] as [[cell adhesion]] molecules and receptors. This protein, like other neurexin proteins, contains [[epidermal growth factor]] repeats and [[laminin]] G domains. In addition, it includes an F5/8 type C domain, discoidin/[[neuropilin]]- and [[fibrinogen]]-like domains, and thrombospondin N-terminal-like domains. [[Alternative splicing]] results in two transcript variants encoding different [[isoforms]].<ref name="entrez" /> | ||
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*{{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }} | *{{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }} | ||
*{{cite journal | vauthors=Nagase T, Kikuno R, Hattori A |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347 |display-authors=etal}} | *{{cite journal | vauthors=Nagase T, Kikuno R, Hattori A |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347 |display-authors=etal}} | ||
*{{cite journal | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal= | *{{cite journal | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi= |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.[1][2]
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.[2]
References
- ↑ Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci. 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID 12093160.
- ↑ 2.0 2.1 "Entrez Gene: CNTNAP4 contactin associated protein-like 4".
External links
- Human CNTNAP4 genome location and CNTNAP4 gene details page in the UCSC Genome Browser.
Further reading
- Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
- Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
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