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{{Infobox_gene}}
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'''Secreted frizzled-related protein 2''' is a [[protein]] that in humans is encoded by the ''SFRP2'' [[gene]].<ref name="pmid9391078">{{cite journal | vauthors = Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR | title = SARPs: A family of secreted apoptosis-related proteins | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 25 | pages = 13636–41 |date=Jan 1998 | pmid = 9391078 | pmc = 28358 | doi =10.1073/pnas.94.25.13636 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SFRP2 secreted frizzled-related protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6423| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Secreted frizzled-related protein 2
| HGNCid = 10777
| Symbol = SFRP2
| AltSymbols =; FRP-2; SARP1; SDF-5
| OMIM = 604157
| ECnumber = 
| Homologene = 56438
| MGIid = 108078
| GeneAtlas_image1 = PBB_GE_SFRP2_gnf1h04341_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFRP2_gnf1h07261_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6423
    | Hs_Ensembl = ENSG00000145423
    | Hs_RefseqProtein = NP_003004
    | Hs_RefseqmRNA = NM_003013
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 154921194
    | Hs_GenLoc_end = 154929678
    | Hs_Uniprot = Q96HF1
    | Mm_EntrezGene = 20319
    | Mm_Ensembl = ENSMUSG00000027996
    | Mm_RefseqmRNA = NM_009144
    | Mm_RefseqProtein = NP_033170
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 83852248
    | Mm_GenLoc_end = 83860242
    | Mm_Uniprot = Q3UI35
  }}
}}
'''Secreted frizzled-related protein 2''', also known as '''SFRP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRP2 secreted frizzled-related protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6423| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.<ref name="entrez">{{cite web | title = Entrez Gene: SFRP2 secreted frizzled-related protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6423| accessdate = }}</ref>
| summary_text = This gene encodes a member of the SFRP family that contains a [[cysteine]]-rich domain homologous to the putative Wnt-binding site of [[Frizzled]] proteins. SFRPs act as soluble modulators of [[Wnt signaling]]. [[DNA methylation|Methylation]] of this gene is a potential marker for the presence of [[colorectal cancer]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Rattner A, Hsieh JC, Smallwood PM, ''et al.'' |title=A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2859-63 |year= 1997 |pmid= 9096311 |doi=  }}
*{{cite journal   |vauthors=Rattner A, Hsieh JC, Smallwood PM, etal |title=A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2859–63 |year= 1997 |pmid= 9096311 |doi=10.1073/pnas.94.7.2859  | pmc=20287 }}
*{{cite journal | author=Melkonyan HS, Chang WC, Shapiro JP, ''et al.'' |title=SARPs: a family of secreted apoptosis-related proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13636-41 |year= 1998 |pmid= 9391078 |doi= }}
*{{cite journal   |vauthors=Hu E, Zhu Y, Fredrickson T, etal |title=Tissue restricted expression of two human Frzbs in preadipocytes and pancreas |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 287–93 |year= 1998 |pmid= 9642118 |doi= 10.1006/bbrc.1998.8784 }}
*{{cite journal  | author=Hu E, Zhu Y, Fredrickson T, ''et al.'' |title=Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 287-93 |year= 1998 |pmid= 9642118 |doi= 10.1006/bbrc.1998.8784 }}
*{{cite journal  | vauthors=Lescher B, Haenig B, Kispert A |title=sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney |journal=Dev. Dyn. |volume=213 |issue= 4 |pages= 440–51 |year= 1999 |pmid= 9853965 |doi= 10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6 }}
*{{cite journal | author=Lescher B, Haenig B, Kispert A |title=sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. |journal=Dev. Dyn. |volume=213 |issue= 4 |pages= 440-51 |year= 1999 |pmid= 9853965 |doi= 10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6 }}
*{{cite journal   |vauthors=Chang JT, Esumi N, Moore K, etal |title=Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 575–83 |year= 1999 |pmid= 10072424 |doi=10.1093/hmg/8.4.575  }}
*{{cite journal | author=Chang JT, Esumi N, Moore K, ''et al.'' |title=Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 575-83 |year= 1999 |pmid= 10072424 |doi=  }}
*{{cite journal   |vauthors=Lee CS, Buttitta LA, May NR, etal |title=SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm |journal=Development |volume=127 |issue= 1 |pages= 109–18 |year= 2000 |pmid= 10654605 |doi=  }}
*{{cite journal | author=Lee CS, Buttitta LA, May NR, ''et al.'' |title=SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. |journal=Development |volume=127 |issue= 1 |pages= 109-18 |year= 2000 |pmid= 10654605 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Brophy PD, Lang KM, Dressler GR |title=The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52401–5 |year= 2004 |pmid= 14561758 |doi= 10.1074/jbc.M305614200 }}
*{{cite journal | author=Brophy PD, Lang KM, Dressler GR |title=The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52401-5 |year= 2004 |pmid= 14561758 |doi= 10.1074/jbc.M305614200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Lee JL, Lin CT, Chueh LL, Chang CJ |title=Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14602–9 |year= 2004 |pmid= 14709558 |doi= 10.1074/jbc.M309008200 }}
*{{cite journal | author=Lee JL, Lin CT, Chueh LL, Chang CJ |title=Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14602-9 |year= 2004 |pmid= 14709558 |doi= 10.1074/jbc.M309008200 }}
*{{cite journal   |vauthors=Müller HM, Oberwalder M, Fiegl H, etal |title=Methylation changes in faecal DNA: a marker for colorectal cancer screening? |journal=Lancet |volume=363 |issue= 9417 |pages= 1283–5 |year= 2004 |pmid= 15094274 |doi= 10.1016/S0140-6736(04)16002-9 }}
*{{cite journal | author=Müller HM, Oberwalder M, Fiegl H, ''et al.'' |title=Methylation changes in faecal DNA: a marker for colorectal cancer screening? |journal=Lancet |volume=363 |issue= 9417 |pages= 1283-5 |year= 2004 |pmid= 15094274 |doi= 10.1016/S0140-6736(04)16002-9 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Clément G, Braunschweig R, Pasquier N, etal |title=Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus |journal=Oncogene |volume=25 |issue= 21 |pages= 3084–92 |year= 2006 |pmid= 16407829 |doi= 10.1038/sj.onc.1209338 }}
*{{cite journal | author=Clément G, Braunschweig R, Pasquier N, ''et al.'' |title=Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus. |journal=Oncogene |volume=25 |issue= 21 |pages= 3084-92 |year= 2006 |pmid= 16407829 |doi= 10.1038/sj.onc.1209338 }}
*{{cite journal   |vauthors=Urakami S, Shiina H, Enokida H, etal |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 }}
*{{cite journal | author=Urakami S, Shiina H, Enokida H, ''et al.'' |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109-16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Huang ZH, Li LH, Yang F, Wang JF |title=Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions |journal=World J. Gastroenterol. |volume=13 |issue= 6 |pages= 950–4 |year= 2007 |pmid= 17352030 |doi= 10.3748/wjg.v13.i6.950}}
*{{cite journal  | author=Huang ZH, Li LH, Yang F, Wang JF |title=Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. |journal=World J. Gastroenterol. |volume=13 |issue= 6 |pages= 950-4 |year= 2007 |pmid= 17352030 |doi=  }}
}}
}}
*{{cite journal  | vauthors=Veeck J, Noetzel E, Bektas N, Jost E, Hartmann A, Knuchel R, Dahl E |title=Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer |journal=Mol Cancer |volume=7 |issue= 83 |pages= 83|year= 2008 |pmid= 18990230  |doi=10.1186/1476-4598-7-83  | pmc=2613402  }}
{{refend}}
{{refend}}


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Latest revision as of 12:04, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.[1][2]

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[2]

References

  1. ↑ Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.
  2. ↑ 2.0 2.1 "Entrez Gene: SFRP2 secreted frizzled-related protein 2".

Further reading



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