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*{{cite journal | vauthors=van Baal J, de Widt J, Divecha N, van Blitterswijk WJ |title=Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 9870–8 |year= 2005 |pmid= 15632189 |doi= 10.1074/jbc.M409301200 }} | *{{cite journal | vauthors=van Baal J, de Widt J, Divecha N, van Blitterswijk WJ |title=Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 9870–8 |year= 2005 |pmid= 15632189 |doi= 10.1074/jbc.M409301200 }} | ||
*{{cite journal | author=Tabellini G |title=Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus |journal=Exp. Cell Res. |volume=287 |issue= 1 |pages= 143–54 |year= 2003 |pmid= 12799190 |doi=10.1016/S0014-4827(03)00115-0 |name-list-format=vanc| author2=Bortul R | author3=Santi S | display-authors=3 | last4=Riccio | first4=Massimo | last5=Baldini | first5=Giovanna | last6=Cappellini | first6=Alessandra | last7=Billi | first7=Anna Maria | last8=Berezney | first8=Ronald | last9=Ruggeri | first9=Alessandra }} | *{{cite journal | author=Tabellini G |title=Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus |journal=Exp. Cell Res. |volume=287 |issue= 1 |pages= 143–54 |year= 2003 |pmid= 12799190 |doi=10.1016/S0014-4827(03)00115-0 |name-list-format=vanc| author2=Bortul R | author3=Santi S | display-authors=3 | last4=Riccio | first4=Massimo | last5=Baldini | first5=Giovanna | last6=Cappellini | first6=Alessandra | last7=Billi | first7=Anna Maria | last8=Berezney | first8=Ronald | last9=Ruggeri | first9=Alessandra }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | author=Houssa B |title=Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 6820–2 |year= 1999 |pmid= 10066731 |doi=10.1074/jbc.274.11.6820 |name-list-format=vanc| author2=de Widt J | author3=Kranenburg O | display-authors=3 | last4=Moolenaar | first4=WH | last5=Van Blitterswijk | first5=WJ }} | *{{cite journal | author=Houssa B |title=Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 6820–2 |year= 1999 |pmid= 10066731 |doi=10.1074/jbc.274.11.6820 |name-list-format=vanc| author2=de Widt J | author3=Kranenburg O | display-authors=3 | last4=Moolenaar | first4=WH | last5=Van Blitterswijk | first5=WJ }} | ||
*{{cite journal | author=Sakane F |title=Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8394–401 |year= 1996 |pmid= 8626538 |doi=10.1074/jbc.271.14.8394 |name-list-format=vanc| author2=Imai S | author3=Kai M | display-authors=3 | last4=Wada | first4=I | last5=Kanoh | first5=H }} | *{{cite journal | author=Sakane F |title=Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8394–401 |year= 1996 |pmid= 8626538 |doi=10.1074/jbc.271.14.8394 |name-list-format=vanc| author2=Imai S | author3=Kai M | display-authors=3 | last4=Wada | first4=I | last5=Kanoh | first5=H }} | ||
Latest revision as of 12:07, 10 January 2019
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Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.[1][2][3]
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[3]
Interactions
DGKQ has been shown to interact with RHOA.[4]
References
- ↑ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.
- ↑ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.
- ↑ 3.0 3.1 "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".
- ↑ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. UNITED STATES. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.
Further reading
- Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
- Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
- van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
- Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
- Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
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