UPF2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Regulator of nonsense transcripts 2''' is a [[protein]] that in humans is encoded by the ''UPF2'' [[gene]].<ref name="pmid11073994">{{cite journal | vauthors = Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC | title = Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes | journal = Molecular and Cellular Biology | volume = 20 | issue = 23 | pages = 8944–57 | date = Dec 2000 | pmid = 11073994 | pmc = 86549 | doi = 10.1128/MCB.20.23.8944-8957.2000 }}</ref><ref name="pmid11113196">{{cite journal | vauthors = Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE | title = Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4) | journal = Molecular and Cellular Biology | volume = 21 | issue = 1 | pages = 209–23 | date = Jan 2001 | pmid = 11113196 | pmc = 88795 | doi = 10.1128/MCB.21.1.209-223.2001 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26019| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_UPF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uw4.
| PDB = {{PDB2|1uw4}}
| Name = UPF2 regulator of nonsense transcripts homolog (yeast)
| HGNCid = 17854
| Symbol = UPF2
| AltSymbols =; DKFZP434D222; HUPF2; KIAA1408; MGC138834; MGC138835; RENT2
| OMIM = 605529
| ECnumber = 
| Homologene = 6101
| MGIid = 2449307
| GeneAtlas_image1 = PBB_GE_UPF2_203519_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000184 |text = mRNA catabolic process, nonsense-mediated decay}} {{GNF_GO|id=GO:0006406 |text = mRNA export from nucleus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26019
    | Hs_Ensembl = ENSG00000151461
    | Hs_RefseqProtein = NP_056357
    | Hs_RefseqmRNA = NM_015542
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 12002027
    | Hs_GenLoc_end = 12125029
    | Hs_Uniprot = Q9HAU5
    | Mm_EntrezGene = 326622
    | Mm_Ensembl = ENSMUSG00000043241
    | Mm_RefseqmRNA = XM_140801
    | Mm_RefseqProtein = XP_140801
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 5868741
    | Mm_GenLoc_end = 5973969
    | Mm_Uniprot = 
  }}
}}
'''UPF2 regulator of nonsense transcripts homolog (yeast)''', also known as '''UPF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26019| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that is part of a post-splicing multiprotein complex, the [[exon junction complex]], involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26019| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Wilson KF, Fortes P, Singh US, ''et al.'' |title=The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4166-73 |year= 1999 |pmid= 9933612 |doi=  }}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal  | author=Mendell JT, Medghalchi SM, Lake RG, ''et al.'' |title=Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8944-57 |year= 2000 |pmid= 11073994 |doi=  }}
*{{cite journal  | author=Serin G, Gersappe A, Black JD, ''et al.'' |title=Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). |journal=Mol. Cell. Biol. |volume=21 |issue= 1 |pages= 209-23 |year= 2001 |pmid= 11113196 |doi= 10.1128/MCB.21.1.209-223.2001 }}
*{{cite journal  | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. |journal=Cell |volume=103 |issue= 7 |pages= 1121-31 |year= 2001 |pmid= 11163187 |doi=  }}
*{{cite journal  | author=Yamashita A, Ohnishi T, Kashima I, ''et al.'' |title=Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. |journal=Genes Dev. |volume=15 |issue= 17 |pages= 2215-28 |year= 2001 |pmid= 11544179 |doi= 10.1101/gad.913001 }}
*{{cite journal  | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. |journal=Science |volume=293 |issue= 5536 |pages= 1836-9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786 }}
*{{cite journal  | author=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536-45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345 }}
*{{cite journal  | author=Lykke-Andersen J |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8114-21 |year= 2003 |pmid= 12417715 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Chiu SY, Serin G, Ohara O, Maquat LE |title=Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. |journal=RNA |volume=9 |issue= 1 |pages= 77-87 |year= 2003 |pmid= 12554878 |doi=  }}
*{{cite journal  | author=Gehring NH, Neu-Yilik G, Schell T, ''et al.'' |title=Y14 and hUpf3b form an NMD-activating complex. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 939-49 |year= 2003 |pmid= 12718880 |doi=  }}
*{{cite journal  | author=Schell T, Köcher T, Wilm M, ''et al.'' |title=Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 775-83 |year= 2003 |pmid= 12723973 |doi= 10.1042/BJ20021920 }}
*{{cite journal  | author=Lejeune F, Li X, Maquat LE |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 675-87 |year= 2003 |pmid= 14527413 |doi=  }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Ohnishi T, Yamashita A, Kashima I, ''et al.'' |title=Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1187-200 |year= 2004 |pmid= 14636577 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Kadlec J, Izaurralde E, Cusack S |title=The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 4 |pages= 330-7 |year= 2004 |pmid= 15004547 |doi= 10.1038/nsmb741 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Lejeune F, Ranganathan AC, Maquat LE |title=eIF4G is required for the pioneer round of translation in mammalian cells. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 992-1000 |year= 2004 |pmid= 15361857 |doi= 10.1038/nsmb824 }}
}}
{{refend}}


{{protein-stub}}
UPF2 has been shown to [[Protein-protein interaction|interact]] with [[UPF1]],<ref name=pmid11073994 /><ref name=pmid14527413>{{cite journal | vauthors = Lejeune F, Li X, Maquat LE | title = Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 675–87 | date = Sep 2003 | pmid = 14527413 | doi = 10.1016/S1097-2765(03)00349-6 }}</ref><ref name=pmid12723973>{{cite journal | vauthors = Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW | title = Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells | journal = The Biochemical Journal | volume = 373 | issue = Pt 3 | pages = 775–83 | date = Aug 2003 | pmid = 12723973 | pmc = 1223536 | doi = 10.1042/BJ20021920 }}</ref><ref name=pmid11544179>{{cite journal | vauthors = Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S | title = Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay | journal = Genes & Development | volume = 15 | issue = 17 | pages = 2215–28 | date = Sep 2001 | pmid = 11544179 | pmc = 312771 | doi = 10.1101/gad.913001 }}</ref><ref name=pmid11163187>{{cite journal | vauthors = Lykke-Andersen J, Shu MD, Steitz JA | title = Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon | journal = Cell | volume = 103 | issue = 7 | pages = 1121–31 | date = Dec 2000 | pmid = 11163187 | doi = 10.1016/S0092-8674(00)00214-2 }}</ref> [[UPF3A]]<ref name=pmid14527413/><ref name=pmid11163187/> and [[UPF3B]].<ref name=pmid14527413/><ref name=pmid11163187/><ref name=pmid15231747>{{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}</ref><ref name=pmid12417715>{{cite journal | vauthors = Lykke-Andersen J | title = Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay | journal = Molecular and Cellular Biology | volume = 22 | issue = 23 | pages = 8114–21 | date = Dec 2002 | pmid = 12417715 | pmc = 134073 | doi = 10.1128/MCB.22.23.8114-8121.2002 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA | title = The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction | journal = The Journal of Biological Chemistry | volume = 274 | issue = 7 | pages = 4166–73 | date = Feb 1999 | pmid = 9933612 | doi = 10.1074/jbc.274.7.4166 }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 1 | pages = 65–73 | date = Feb 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
* {{cite journal | vauthors = Lykke-Andersen J, Shu MD, Steitz JA | title = Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon | journal = Cell | volume = 103 | issue = 7 | pages = 1121–31 | date = Dec 2000 | pmid = 11163187 | doi = 10.1016/S0092-8674(00)00214-2 }}
* {{cite journal | vauthors = Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S | title = Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay | journal = Genes & Development | volume = 15 | issue = 17 | pages = 2215–28 | date = Sep 2001 | pmid = 11544179 | pmc = 312771 | doi = 10.1101/gad.913001 }}
* {{cite journal | vauthors = Lykke-Andersen J, Shu MD, Steitz JA | title = Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 | journal = Science | volume = 293 | issue = 5536 | pages = 1836–9 | date = Sep 2001 | pmid = 11546874 | doi = 10.1126/science.1062786 }}
* {{cite journal | vauthors = Lejeune F, Ishigaki Y, Li X, Maquat LE | title = The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3536–45 | date = Jul 2002 | pmid = 12093754 | pmc = 126094 | doi = 10.1093/emboj/cdf345 }}
* {{cite journal | vauthors = Lykke-Andersen J | title = Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay | journal = Molecular and Cellular Biology | volume = 22 | issue = 23 | pages = 8114–21 | date = Dec 2002 | pmid = 12417715 | pmc = 134073 | doi = 10.1128/MCB.22.23.8114-8121.2002 }}
* {{cite journal | vauthors = Chiu SY, Serin G, Ohara O, Maquat LE | title = Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 | journal = RNA | volume = 9 | issue = 1 | pages = 77–87 | date = Jan 2003 | pmid = 12554878 | pmc = 1370372 | doi = 10.1261/rna.2137903 }}
* {{cite journal | vauthors = Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE | title = Y14 and hUpf3b form an NMD-activating complex | journal = Molecular Cell | volume = 11 | issue = 4 | pages = 939–49 | date = Apr 2003 | pmid = 12718880 | doi = 10.1016/S1097-2765(03)00142-4 }}
* {{cite journal | vauthors = Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW | title = Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells | journal = The Biochemical Journal | volume = 373 | issue = Pt 3 | pages = 775–83 | date = Aug 2003 | pmid = 12723973 | pmc = 1223536 | doi = 10.1042/BJ20021920 }}
* {{cite journal | vauthors = Lejeune F, Li X, Maquat LE | title = Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 675–87 | date = Sep 2003 | pmid = 14527413 | doi = 10.1016/S1097-2765(03)00349-6 }}
* {{cite journal | vauthors = Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S | title = Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 | journal = Molecular Cell | volume = 12 | issue = 5 | pages = 1187–200 | date = Nov 2003 | pmid = 14636577 | doi = 10.1016/S1097-2765(03)00443-X }}
* {{cite journal | vauthors = Kadlec J, Izaurralde E, Cusack S | title = The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3 | journal = Nature Structural & Molecular Biology | volume = 11 | issue = 4 | pages = 330–7 | date = Apr 2004 | pmid = 15004547 | doi = 10.1038/nsmb741 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Lejeune F, Ranganathan AC, Maquat LE | title = eIF4G is required for the pioneer round of translation in mammalian cells | journal = Nature Structural & Molecular Biology | volume = 11 | issue = 10 | pages = 992–1000 | date = Oct 2004 | pmid = 15361857 | doi = 10.1038/nsmb824 }}
{{Refend}}
 
{{PDB Gallery|geneid=26019}}

Latest revision as of 01:22, 28 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.[1][2][3]

Function

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.[3]

Interactions

UPF2 has been shown to interact with UPF1,[1][4][5][6][7] UPF3A[4][7] and UPF3B.[4][7][8][9]

References

  1. ↑ 1.0 1.1 Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC (Dec 2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes". Molecular and Cellular Biology. 20 (23): 8944–57. doi:10.1128/MCB.20.23.8944-8957.2000. PMC 86549. PMID 11073994.
  2. ↑ Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE (Jan 2001). "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)". Molecular and Cellular Biology. 21 (1): 209–23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795. PMID 11113196.
  3. ↑ 3.0 3.1 "Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)".
  4. ↑ 4.0 4.1 4.2 Lejeune F, Li X, Maquat LE (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
  5. ↑ Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW (Aug 2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". The Biochemical Journal. 373 (Pt 3): 775–83. doi:10.1042/BJ20021920. PMC 1223536. PMID 12723973.
  6. ↑ Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (Sep 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes & Development. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771. PMID 11544179.
  7. ↑ 7.0 7.1 7.2 Lykke-Andersen J, Shu MD, Steitz JA (Dec 2000). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. 103 (7): 1121–31. doi:10.1016/S0092-8674(00)00214-2. PMID 11163187.
  8. ↑ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  9. ↑ Lykke-Andersen J (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=UPF2&oldid=1527283"