PAPSS2: Difference between revisions

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Latest revision as of 14:54, 14 February 2018

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.^[1]^[2]

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.^[2]

References

↑ ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62. doi:10.1038/2458. PMID 9771708.
↑ ^2.0 ^2.1 "Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shimizu C, Fuda H, Lee YC, Strott CA (2002). "Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2". Biochem. J. 363 (Pt 2): 263–71. doi:10.1042/0264-6021:3630263. PMC 1222474. PMID 11931653.
Fuda H, Shimizu C, Lee YC, et al. (2002). "Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms". Biochem. J. 365 (Pt 2): 497–504. doi:10.1042/BJ20020044. PMC 1222679. PMID 11931637.
Xu ZH, Freimuth RR, Eckloff B, et al. (2002). "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes". Pharmacogenetics. 12 (1): 11–21. doi:10.1097/00008571-200201000-00003. PMID 11773860.
Xu Z, Wood TC, Adjei AA, Weinshilboum RM (2001). "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase: radiochemical enzymatic assay, biochemical properties, and hepatic variation". Drug Metab. Dispos. 29 (2): 172–8. PMID 11159808.
Xu ZH, Otterness DM, Freimuth RR, et al. (2000). "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization". Biochem. Biophys. Res. Commun. 268 (2): 437–44. doi:10.1006/bbrc.2000.2123. PMID 10679223.
Besset S, Vincourt JB, Amalric F, Girard JP (2000). "Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells". FASEB J. 14 (2): 345–54. PMID 10657990.
Kurima K, Singh B, Schwartz NB (1999). "Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2". J. Biol. Chem. 274 (47): 33306–12. doi:10.1074/jbc.274.47.33306. PMID 10559207.
Ahmad M, Haque MF, Ahmad W, et al. (1998). "Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred". Am. J. Med. Genet. 78 (5): 468–73. doi:10.1002/(SICI)1096-8628(19980806)78:5<468::AID-AJMG13>3.0.CO;2-D. PMID 9714015.
Kurima K, Warman ML, Krishnan S, et al. (1998). "A member of a family of sulfate-activating enzymes causes murine brachymorphism". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8681–5. doi:10.1073/pnas.95.15.8681. PMC 21136. PMID 9671738.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[pmid9771708-1] ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62. doi:10.1038/2458. PMID 9771708.

[entrez-2] 2.0 ^2.1 "Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{GNF_Protein_box
+'''Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2''' is an [[enzyme]] that in humans is encoded by the ''PAPSS2'' [[gene]].<ref name="pmid9771708">{{cite journal | vauthors = ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH | title = Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse | journal = Nat Genet | volume = 20 | issue = 2 | pages = 157–62 |date=Oct 1998 | pmid = 9771708 | pmc =  | doi = 10.1038/2458 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9060| accessdate = }}</ref>
- | image = PBB_Protein_PAPSS2_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ax4.
- | PDB = {{PDB2|2ax4}}
- | Name = 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- | HGNCid = 8604
- | Symbol = PAPSS2
- | AltSymbols =; SK2; ATPSK2
- | OMIM = 603005
- | ECnumber =
- | Homologene = 55840
- | MGIid = 1330223
- | GeneAtlas_image1 = PBB_GE_PAPSS2_203058_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PAPSS2_203059_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_PAPSS2_203060_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004020 |text = adenylylsulfate kinase activity}} {{GNF_GO|id=GO:0004781 |text = sulfate adenylyltransferase (ATP) activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016779 |text = nucleotidyltransferase activity}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
- | Process = {{GNF_GO|id=GO:0000103 |text = sulfate assimilation}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9060
-    | Hs_Ensembl = ENSG00000198682
-    | Hs_RefseqProtein = NP_001015880
-    | Hs_RefseqmRNA = NM_001015880
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 10
-    | Hs_GenLoc_start = 89409350
-    | Hs_GenLoc_end = 89497442
-    | Hs_Uniprot = O95340
-    | Mm_EntrezGene = 23972
-    | Mm_Ensembl = ENSMUSG00000024899
-    | Mm_RefseqmRNA = XM_993984
-    | Mm_RefseqProtein = XP_999078
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 19
-    | Mm_GenLoc_start = 32686002
-    | Mm_GenLoc_end = 32733184
-    | Mm_Uniprot = Q5BKP4
-  }}
-}}
-'''3'-phosphoadenosine 5'-phosphosulfate synthase 2''', also known as '''PAPSS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9060| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9060| accessdate = }}</ref>
+| summary_text = [[Sulfation]] is a common modification of endogenous ([[lipids]], [[proteins]], and [[carbohydrates]]) and exogenous ([[xenobiotics]] and drugs) compounds. In [[mammals]], the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate ([[PAPS]]), created from ATP and inorganic [[sulfate]]. Two different tissue [[isoforms]] encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of [[spondyloepimetaphyseal dysplasia]]. Two alternatively spliced transcript variants that encode different [[isoforms]] have been described for this gene.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
+*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Shimizu C, Fuda H, Lee YC, Strott CA |title=Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2. |journal=Biochem. J. |volume=363 |issue= Pt 2 |pages= 263-71 |year= 2002 |pmid= 11931653 |doi=  }}
+*{{cite journal  | vauthors=Shimizu C, Fuda H, Lee YC, Strott CA |title=Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2 |journal=Biochem. J. |volume=363 |issue= Pt 2 |pages= 263–71 |year= 2002 |pmid= 11931653 |doi=10.1042/0264-6021:3630263  | pmc=1222474  }}
-*{{cite journal  | author=Fuda H, Shimizu C, Lee YC, ''et al.'' |title=Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 497-504 |year= 2002 |pmid= 11931637 |doi= 10.1042/BJ20020044 }}
+*{{cite journal   |vauthors=Fuda H, Shimizu C, Lee YC, etal |title=Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 497–504 |year= 2002 |pmid= 11931637 |doi= 10.1042/BJ20020044  | pmc=1222679 }}
-*{{cite journal  | author=Xu ZH, Freimuth RR, Eckloff B, ''et al.'' |title=Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes. |journal=Pharmacogenetics |volume=12 |issue= 1 |pages= 11-21 |year= 2002 |pmid= 11773860 |doi=  }}
+*{{cite journal   |vauthors=Xu ZH, Freimuth RR, Eckloff B, etal |title=Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes |journal=Pharmacogenetics |volume=12 |issue= 1 |pages= 11–21 |year= 2002 |pmid= 11773860 |doi=10.1097/00008571-200201000-00003  }}
-*{{cite journal  | author=Xu Z, Wood TC, Adjei AA, Weinshilboum RM |title=Human 3'-phosphoadenosine 5'-phosphosulfate synthetase: radiochemical enzymatic assay, biochemical properties, and hepatic variation. |journal=Drug Metab. Dispos. |volume=29 |issue= 2 |pages= 172-8 |year= 2001 |pmid= 11159808 |doi=  }}
+*{{cite journal  | vauthors=Xu Z, Wood TC, Adjei AA, Weinshilboum RM |title=Human 3'-phosphoadenosine 5'-phosphosulfate synthetase: radiochemical enzymatic assay, biochemical properties, and hepatic variation |journal=Drug Metab. Dispos. |volume=29 |issue= 2 |pages= 172–8 |year= 2001 |pmid= 11159808 |doi=  }}
-*{{cite journal  | author=Xu ZH, Otterness DM, Freimuth RR, ''et al.'' |title=Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 437-44 |year= 2000 |pmid= 10679223 |doi= 10.1006/bbrc.2000.2123 }}
+*{{cite journal   |vauthors=Xu ZH, Otterness DM, Freimuth RR, etal |title=Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 437–44 |year= 2000 |pmid= 10679223 |doi= 10.1006/bbrc.2000.2123 }}
-*{{cite journal  | author=Besset S, Vincourt JB, Amalric F, Girard JP |title=Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. |journal=FASEB J. |volume=14 |issue= 2 |pages= 345-54 |year= 2000 |pmid= 10657990 |doi=  }}
+*{{cite journal  | vauthors=Besset S, Vincourt JB, Amalric F, Girard JP |title=Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells |journal=FASEB J. |volume=14 |issue= 2 |pages= 345–54 |year= 2000 |pmid= 10657990 |doi=  }}
-*{{cite journal  | author=Kurima K, Singh B, Schwartz NB |title=Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33306-12 |year= 1999 |pmid= 10559207 |doi=  }}
+*{{cite journal  | vauthors=Kurima K, Singh B, Schwartz NB |title=Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2 |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33306–12 |year= 1999 |pmid= 10559207 |doi=10.1074/jbc.274.47.33306  }}
-*{{cite journal  | author=ul Haque MF, King LM, Krakow D, ''et al.'' |title=Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse. |journal=Nat. Genet. |volume=20 |issue= 2 |pages= 157-62 |year= 1998 |pmid= 9771708 |doi= 10.1038/2458 }}
+*{{cite journal   |vauthors=Ahmad M, Haque MF, Ahmad W, etal |title=Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred |journal=Am. J. Med. Genet. |volume=78 |issue= 5 |pages= 468–73 |year= 1998 |pmid= 9714015 |doi=10.1002/(SICI)1096-8628(19980806)78:5<468::AID-AJMG13>3.0.CO;2-D  }}
-*{{cite journal  | author=Ahmad M, Haque MF, Ahmad W, ''et al.'' |title=Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred. |journal=Am. J. Med. Genet. |volume=78 |issue= 5 |pages= 468-73 |year= 1998 |pmid= 9714015 |doi=  }}
+*{{cite journal   |vauthors=Kurima K, Warman ML, Krishnan S, etal |title=A member of a family of sulfate-activating enzymes causes murine brachymorphism |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8681–5 |year= 1998 |pmid= 9671738 |doi=10.1073/pnas.95.15.8681  | pmc=21136  }}
-*{{cite journal  | author=Kurima K, Warman ML, Krishnan S, ''et al.'' |title=A member of a family of sulfate-activating enzymes causes murine brachymorphism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8681-5 |year= 1998 |pmid= 9671738 |doi=  }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=9060}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
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+{{Kinases}}
+{{Proteoglycan metabolism enzymes}}
-{{protein-stub}}
+{{gene-10-stub}}
-{{WikiDoc Sources}}

PAPSS2: Difference between revisions

Latest revision as of 14:54, 14 February 2018

References

Further reading

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