ANXA8L2: Difference between revisions

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Latest revision as of 08:40, 5 December 2018

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.^[1]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: ANXA8 annexin A8".

External links

Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser.
Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser.

Gerke V, Moss SE (2002). "Annexins: from structure to function". Physiol. Rev. 82 (2): 331–71. doi:10.1152/physrev.00030.2001. PMID 11917092.
Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signaling to membrane dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. doi:10.1038/nrm1661. PMID 15928709.
Chang KS, Wang G, Freireich EJ, et al. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia". Blood. 79 (7): 1802–10. PMID 1313714.
Chambers JA, Gardner E, Hauptmann R, et al. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8)". Hum. Mol. Genet. 1 (7): 550. doi:10.1093/hmg/1.7.550. PMID 1364010.
Hauptmann R, Maurer-Fogy I, Krystek E, et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. doi:10.1111/j.1432-1033.1989.tb15082.x. PMID 2530088.
Sarkar A, Yang P, Fan YH, et al. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia". Blood. 84 (1): 279–86. PMID 8018923.
Reutelingsperger CP, van Heerde W, Hauptmann R, et al. (1994). "Differential tissue expression of Annexin VIII in human". FEBS Lett. 349 (1): 120–4. doi:10.1016/0014-5793(94)00559-1. PMID 8045287.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stein T, Price KN, Morris JS, et al. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. doi:10.1158/1078-0432.CCR-05-0547. PMID 16203777.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties". FEBS Lett. 580 (10): 2430–4. doi:10.1016/j.febslet.2006.03.076. PMID 16638567.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: ANXA8 annexin A8".

[1]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Annexin A8-like protein 2''' is a [[protein]] that in [[human]]s is encoded by the ''ANXA8L2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANXA8 annexin A8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image = PBB_Protein_ANXA8_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1w3w.
- | PDB = {{PDB2|1w3w}}, {{PDB2|1w45}}
- | Name = Annexin A8
- | HGNCid = 546
- | Symbol = ANXA8
- | AltSymbols =; ANX8; ANXA8L2; FLJ32754; VAC beta
- | OMIM = 602396
- | ECnumber =
- | Homologene = 88650
- | MGIid =
- | Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005544 |text = calcium-dependent phospholipid binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 244
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_001621
-    | Hs_RefseqmRNA = NM_001630
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Annexin A8''', also known as '''ANXA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANXA8 annexin A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.<ref name="entrez">{{cite web | title = Entrez Gene: ANXA8 annexin A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}</ref>
+| summary_text = This [[gene]] encodes a member of the [[annexin]] family of evolutionarily conserved Ca2+ and [[phospholipid]] [[binding protein]]s. The encoded protein may function as an [[anticoagulant]] that indirectly inhibits the [[thromboplastin]]-specific complex. Overexpression of this gene has been associated with [[acute myelocytic leukemia]]. A highly similar duplicated copy of this gene is found in close proximity on the long arm of [[chromosome 10]].<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|ANXA8}}
+* {{UCSC gene info|ANXA8L1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Gerke V, Moss SE |title=Annexins: from structure to function. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 331-71 |year= 2002 |pmid= 11917092 |doi= 10.1152/physrev.00030.2001 }}
+*{{cite journal  |vauthors=Gerke V, Moss SE |title=Annexins: from structure to function. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 331–71 |year= 2002 |pmid= 11917092 |doi= 10.1152/physrev.00030.2001 }}
-*{{cite journal  | author=Gerke V, Creutz CE, Moss SE |title=Annexins: linking Ca2+ signalling to membrane dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 449-61 |year= 2005 |pmid= 15928709 |doi= 10.1038/nrm1661 }}
+*{{cite journal  |vauthors=Gerke V, Creutz CE, Moss SE |title=Annexins: linking Ca2+ signaling to membrane dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 449–61 |year= 2005 |pmid= 15928709 |doi= 10.1038/nrm1661 }}
-*{{cite journal  | author=Chang KS, Wang G, Freireich EJ, ''et al.'' |title=Specific expression of the annexin VIII gene in acute promyelocytic leukemia. |journal=Blood |volume=79 |issue= 7 |pages= 1802-10 |year= 1992 |pmid= 1313714 |doi=  }}
+*{{cite journal  |vauthors=Chang KS, Wang G, Freireich EJ |title=Specific expression of the annexin VIII gene in acute promyelocytic leukemia. |journal=Blood |volume=79 |issue= 7 |pages= 1802–10 |year= 1992 |pmid= 1313714 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Chambers JA, Gardner E, Hauptmann R, ''et al.'' |title=TaqI polymorphisms at the annexin VIII locus (ANX8). |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 550 |year= 1993 |pmid= 1364010 |doi=  }}
+*{{cite journal  |vauthors=Chambers JA, Gardner E, Hauptmann R |title=TaqI polymorphisms at the annexin VIII locus (ANX8). |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 550 |year= 1993 |pmid= 1364010 |doi=10.1093/hmg/1.7.550  |display-authors=etal}}
-*{{cite journal  | author=Hauptmann R, Maurer-Fogy I, Krystek E, ''et al.'' |title=Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. |journal=Eur. J. Biochem. |volume=185 |issue= 1 |pages= 63-71 |year= 1989 |pmid= 2530088 |doi=  }}
+*{{cite journal  |vauthors=Hauptmann R, Maurer-Fogy I, Krystek E |title=Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. |journal=Eur. J. Biochem. |volume=185 |issue= 1 |pages= 63–71 |year= 1989 |pmid= 2530088 |doi=10.1111/j.1432-1033.1989.tb15082.x  |display-authors=etal}}
-*{{cite journal  | author=Sarkar A, Yang P, Fan YH, ''et al.'' |title=Regulation of the expression of annexin VIII in acute promyelocytic leukemia. |journal=Blood |volume=84 |issue= 1 |pages= 279-86 |year= 1994 |pmid= 8018923 |doi=  }}
+*{{cite journal  |vauthors=Sarkar A, Yang P, Fan YH |title=Regulation of the expression of annexin VIII in acute promyelocytic leukemia. |journal=Blood |volume=84 |issue= 1 |pages= 279–86 |year= 1994 |pmid= 8018923 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Reutelingsperger CP, van Heerde W, Hauptmann R, ''et al.'' |title=Differential tissue expression of Annexin VIII in human. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 120-4 |year= 1994 |pmid= 8045287 |doi=  }}
+*{{cite journal  |vauthors=Reutelingsperger CP, van Heerde W, Hauptmann R |title=Differential tissue expression of Annexin VIII in human. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 120–4 |year= 1994 |pmid= 8045287 |doi=10.1016/0014-5793(94)00559-1  |display-authors=etal}}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
+*{{cite journal  |vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Stein T, Price KN, Morris JS, ''et al.'' |title=Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6872-9 |year= 2006 |pmid= 16203777 |doi= 10.1158/1078-0432.CCR-05-0547 }}
+*{{cite journal  |vauthors=Stein T, Price KN, Morris JS |title=Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6872–9 |year= 2006 |pmid= 16203777 |doi= 10.1158/1078-0432.CCR-05-0547 |display-authors=etal}}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+*{{cite journal  |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 |display-authors=etal}}
-*{{cite journal  | author=Goebeler V, Ruhe D, Gerke V, Rescher U |title=Annexin A8 displays unique phospholipid and F-actin binding properties. |journal=FEBS Lett. |volume=580 |issue= 10 |pages= 2430-4 |year= 2006 |pmid= 16638567 |doi= 10.1016/j.febslet.2006.03.076 }}
+*{{cite journal  |vauthors=Goebeler V, Ruhe D, Gerke V, Rescher U |title=Annexin A8 displays unique phospholipid and F-actin binding properties. |journal=FEBS Lett. |volume=580 |issue= 10 |pages= 2430–4 |year= 2006 |pmid= 16638567 |doi= 10.1016/j.febslet.2006.03.076 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=244}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 {{protein-stub}}
-{{WikiDoc Sources}}

ANXA8L2: Difference between revisions

Latest revision as of 08:40, 5 December 2018

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