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{{Infobox_gene}}
{{PBB_Controls
'''DNA/RNA-binding protein KIN17''' is a [[protein]] that in humans is encoded by the ''KIN'' [[gene]].<ref name="pmid1923796">{{cite journal |vauthors=Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R | title = Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein | journal = Nucleic Acids Res | volume = 19 | issue = 19 | pages = 5117–23 |date=Nov 1991 | pmid = 1923796 | pmc = 328864 | doi =10.1093/nar/19.19.5117 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22944| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KIN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ckk.
| PDB = {{PDB2|2ckk}}
| Name = KIN, antigenic determinant of recA protein homolog (mouse)
| HGNCid = 6327
| Symbol = KIN
| AltSymbols =; BTCD; KIN17
| OMIM = 601720
| ECnumber = 
| Homologene = 8196
| MGIid = 96676
| GeneAtlas_image1 = PBB_GE_KIN_205664_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22944
    | Hs_Ensembl = ENSG00000151657
    | Hs_RefseqProtein = NP_036443
    | Hs_RefseqmRNA = NM_012311
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 7837198
    | Hs_GenLoc_end = 7869950
    | Hs_Uniprot =  
    | Mm_EntrezGene = 16588
    | Mm_Ensembl = ENSMUSG00000037262
    | Mm_RefseqmRNA = NM_025280
    | Mm_RefseqProtein = NP_079556
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 9998465
    | Mm_GenLoc_end = 10010557
    | Mm_Uniprot = 
  }}
}}
'''KIN, antigenic determinant of recA protein homolog (mouse)''', also known as '''KIN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22944| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.<ref name="entrez">{{cite web | title = Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22944| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a [[nuclear protein]] that forms intranuclear foci during proliferation and is redistributed in the [[nucleoplasm]] during the [[cell cycle]]. Short-wave [[ultraviolet light]] provokes the relocalization of the protein, suggesting its participation in the cellular response to [[DNA damage]]. Originally selected based on protein-binding with RecA [[antibodies]], the mouse protein presents a limited similarity with a functional domain of the bacterial [[RecA]] protein, a characteristic shared by this human ortholog.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Angulo JF, Rouer E, Mazin A, ''et al.'' |title=Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein. |journal=Nucleic Acids Res. |volume=19 |issue= 19 |pages= 5117-23 |year= 1991 |pmid= 1923796 |doi=  }}
*{{cite journal   |vauthors=Biard DS, Saintigny Y, Maratrat M, etal |title=Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. |journal=Arch. Dermatol. Res. |volume=289 |issue= 8 |pages= 448–56 |year= 1997 |pmid= 9266022 |doi=10.1007/s004030050220 }}
*{{cite journal  | author=Biard DS, Saintigny Y, Maratrat M, ''et al.'' |title=Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. |journal=Arch. Dermatol. Res. |volume=289 |issue= 8 |pages= 448-56 |year= 1997 |pmid= 9266022 |doi=  }}
*{{cite journal  |vauthors=Kannouche P, Angulo JF |title=Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells. |journal=J. Cell Sci. |volume=112 |issue=  19|pages= 3215–24 |year= 1999 |pmid= 10504327 |doi=  }}
*{{cite journal  | author=Kannouche P, Angulo JF |title=Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells. |journal=J. Cell. Sci. |volume=112 ( Pt 19) |issue=  |pages= 3215-24 |year= 1999 |pmid= 10504327 |doi=  }}
*{{cite journal   |vauthors=Blattner C, Kannouche P, Litfin M, etal |title=UV-Induced stabilization of c-fos and other short-lived mRNAs. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3616–25 |year= 2000 |pmid= 10779351 |doi=10.1128/MCB.20.10.3616-3625.2000  | pmc=85654 }}
*{{cite journal | author=Blattner C, Kannouche P, Litfin M, ''et al.'' |title=UV-Induced stabilization of c-fos and other short-lived mRNAs. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3616-25 |year= 2000 |pmid= 10779351 |doi=  }}
*{{cite journal   |vauthors=Kannouche P, Mauffrey P, Pinon-Lataillade G, etal |title=Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. |journal=Carcinogenesis |volume=21 |issue= 9 |pages= 1701–10 |year= 2000 |pmid= 10964102 |doi=10.1093/carcin/21.9.1701 }}
*{{cite journal | author=Kannouche P, Mauffrey P, Pinon-Lataillade G, ''et al.'' |title=Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. |journal=Carcinogenesis |volume=21 |issue= 9 |pages= 1701-10 |year= 2000 |pmid= 10964102 |doi=  }}
*{{cite journal   |vauthors=Biard DS, Miccoli L, Despras E, etal |title=Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 19156–65 |year= 2002 |pmid= 11880372 |doi= 10.1074/jbc.M200321200 }}
*{{cite journal | author=Biard DS, Miccoli L, Despras E, ''et al.'' |title=Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 19156-65 |year= 2002 |pmid= 11880372 |doi= 10.1074/jbc.M200321200 }}
*{{cite journal  |vauthors=Miccoli L, Biard DS, Créminon C, Angulo JF |title=Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. |journal=Cancer Res. |volume=62 |issue= 19 |pages= 5425–35 |year= 2002 |pmid= 12359749 |doi=  }}
*{{cite journal  | author=Miccoli L, Biard DS, Créminon C, Angulo JF |title=Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. |journal=Cancer Res. |volume=62 |issue= 19 |pages= 5425-35 |year= 2002 |pmid= 12359749 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Masson C, Menaa F, Pinon-Lataillade G, etal |title=Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 616–21 |year= 2003 |pmid= 12525703 |doi= 10.1073/pnas.0236176100 | pmc=141045 }}
*{{cite journal | author=Masson C, Menaa F, Pinon-Lataillade G, ''et al.'' |title=Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 616-21 |year= 2003 |pmid= 12525703 |doi= 10.1073/pnas.0236176100 }}
*{{cite journal   |vauthors=Despras E, Miccoli L, Créminon C, etal |title=Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells. |journal=Radiat. Res. |volume=159 |issue= 6 |pages= 748–58 |year= 2003 |pmid= 12751957 |doi=10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2  | issn=0033-7587 }}
*{{cite journal | author=Despras E, Miccoli L, Créminon C, ''et al.'' |title=Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells. |journal=Radiat. Res. |volume=159 |issue= 6 |pages= 748-58 |year= 2003 |pmid= 12751957 |doi=  }}
*{{cite journal   |vauthors=Biard DS, Miccoli L, Despras E, etal |title=Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes |journal=Mol. Cancer Res. |volume=1 |issue= 7 |pages= 519–31 |year= 2004 |pmid= 12754299 |doi=  }}
*{{cite journal | author=Biard DS, Miccoli L, Despras E, ''et al.'' |title=Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. |journal=Mol. Cancer Res. |volume=1 |issue= 7 |pages= 519-31 |year= 2004 |pmid= 12754299 |doi=  }}
*{{cite journal   |vauthors=Miccoli L, Biard DS, Frouin I, etal |title=Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner |journal=Nucleic Acids Res. |volume=31 |issue= 14 |pages= 4162–75 |year= 2003 |pmid= 12853634 |doi=10.1093/nar/gkg459  | pmc=165974 }}
*{{cite journal | author=Miccoli L, Biard DS, Frouin I, ''et al.'' |title=Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. |journal=Nucleic Acids Res. |volume=31 |issue= 14 |pages= 4162-75 |year= 2003 |pmid= 12853634 |doi=  }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Miccoli L, Frouin I, Novac O, etal |title=The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins |journal=Mol. Cell. Biol. |volume=25 |issue= 9 |pages= 3814–30 |year= 2005 |pmid= 15831485 |doi= 10.1128/MCB.25.9.3814-3830.2005 | pmc=1084281 }}
*{{cite journal | author=Miccoli L, Frouin I, Novac O, ''et al.'' |title=The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. |journal=Mol. Cell. Biol. |volume=25 |issue= 9 |pages= 3814-30 |year= 2005 |pmid= 15831485 |doi= 10.1128/MCB.25.9.3814-3830.2005 }}
*{{cite journal   |vauthors=le Maire A, Schiltz M, Braud S, etal |title=Crystallization and halide phasing of the C-terminal domain of human KIN17 |journal=Acta Crystallographica Section F |volume=62 |issue= Pt 3 |pages= 245–8 |year= 2006 |pmid= 16511313 |doi= 10.1107/S174430910600409X | pmc=2197188 }}
*{{cite journal | author=le Maire A, Schiltz M, Braud S, ''et al.'' |title=Crystallization and halide phasing of the C-terminal domain of human KIN17. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=62 |issue= Pt 3 |pages= 245-8 |year= 2006 |pmid= 16511313 |doi= 10.1107/S174430910600409X }}
*{{cite journal   |vauthors=le Maire A, Schiltz M, Stura EA, etal |title=A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics |journal=J. Mol. Biol. |volume=364 |issue= 4 |pages= 764–76 |year= 2007 |pmid= 17045609 |doi= 10.1016/j.jmb.2006.09.033 }}
*{{cite journal | author=le Maire A, Schiltz M, Stura EA, ''et al.'' |title=A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. |journal=J. Mol. Biol. |volume=364 |issue= 4 |pages= 764-76 |year= 2007 |pmid= 17045609 |doi= 10.1016/j.jmb.2006.09.033 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=22944}}
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Latest revision as of 15:29, 8 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.[1][2]

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[2]

References

  1. ↑ Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R (Nov 1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. doi:10.1093/nar/19.19.5117. PMC 328864. PMID 1923796.
  2. ↑ 2.0 2.1 "Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)".

Further reading



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