HELLS: Difference between revisions

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{{For|the anime film|Hells Angels (manga)}}
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{{Infobox_gene}}
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'''Lymphoid-specific helicase''' is an [[enzyme]] that in humans is encoded by the ''HELLS'' [[gene]].<ref name="pmid9878251">{{cite journal |vauthors=Geiman TM, Durum SK, Muegge K | title = Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh) | journal = Genomics | volume = 54 | issue = 3 | pages = 477–83 |date=Feb 1999 | pmid = 9878251 | pmc =  | doi = 10.1006/geno.1998.5557 }}</ref><ref name="pmid10910076">{{cite journal |vauthors=Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ | title = Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia | journal = Cancer Res | volume = 60 | issue = 13 | pages = 3612–22 |date=Aug 2000 | pmid = 10910076 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HELLS helicase, lymphoid-specific| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3070| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Helicase, lymphoid-specific
| HGNCid = 4861
| Symbol = HELLS
| AltSymbols =; FLJ10339; LSH; Nbla10143; PASG; SMARCA6
| OMIM = 603946
| ECnumber =
| Homologene = 50037
| MGIid = 106209
  | GeneAtlas_image1 = PBB_GE_HELLS_220085_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005721 |text = centric heterochromatin}}
| Process = {{GNF_GO|id=GO:0006346 |text = methylation-dependent chromatin silencing}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0010216 |text = maintenance of DNA methylation}} {{GNF_GO|id=GO:0031508 |text = centric heterochromatin formation}} {{GNF_GO|id=GO:0046651 |text = lymphocyte proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3070
    | Hs_Ensembl = ENSG00000119969
    | Hs_RefseqProtein = NP_060533
    | Hs_RefseqmRNA = NM_018063
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 96295564
    | Hs_GenLoc_end = 96363652
    | Hs_Uniprot = Q9NRZ9
    | Mm_EntrezGene = 15201
    | Mm_Ensembl = ENSMUSG00000025001
    | Mm_RefseqmRNA = NM_008234
    | Mm_RefseqProtein = NP_032260
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 38996098
    | Mm_GenLoc_end = 39033417
    | Mm_Uniprot = Q60848
  }}
}}
'''Helicase, lymphoid-specific''', also known as '''HELLS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HELLS helicase, lymphoid-specific| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3070| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HELLS helicase, lymphoid-specific| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3070| accessdate = }}</ref>
| summary_text = This gene encodes a lymphoid-specific [[helicase]]. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ohira M, Morohashi A, Nakamura Y, ''et al.'' |title=Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. |journal=Cancer Lett. |volume=197 |issue= 1-2 |pages= 63-8 |year= 2003 |pmid= 12880961 |doi=  }}
*{{cite journal  | author=Ohira M |title=Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma |journal=Cancer Lett. |volume=197 |issue= 1–2 |pages= 63–8 |year= 2003 |pmid= 12880961 |doi=10.1016/S0304-3835(03)00085-5  |name-list-format=vanc| author2=Morohashi A  | author3=Nakamura Y  | display-authors=3  | last4=Isogai  | first4=Eriko  | last5=Furuya  | first5=Kazushige  | last6=Hamano  | first6=Shiho  | last7=Machida  | first7=Taiichi  | last8=Aoyama  | first8=Mineyoshi  | last9=Fukumura  | first9=Masayuki }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal  | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  |name-list-format=vanc| author2=Lennon G  | author3=Becker M  | display-authors=3  | last4=Bonaldo  | first4=M F  | last5=Chiapelli  | first5=B  | last6=Chissoe  | first6=S  | last7=Dietrich  | first7=N  | last8=Dubuque  | first8=T  | last9=Favello  | first9=A }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3 | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G }}
*{{cite journal  | author=Geiman TM, Durum SK, Muegge K |title=Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh). |journal=Genomics |volume=54 |issue= 3 |pages= 477-83 |year= 1999 |pmid= 9878251 |doi= 10.1006/geno.1998.5557 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Lee DW, Zhang K, Ning ZQ, ''et al.'' |title=Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. |journal=Cancer Res. |volume=60 |issue= 13 |pages= 3612-22 |year= 2000 |pmid= 10910076 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sun LQ |title=Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG |journal=Genes Dev. |volume=18 |issue= 9 |pages= 1035–46 |year= 2004 |pmid= 15105378 |doi= 10.1101/gad.1176104 | pmc=406293  |name-list-format=vanc| author2=Lee DW  | author3=Zhang Q  | display-authors=3  | last4=Xiao  | first4=W  | last5=Raabe  | first5=EH  | last6=Meeker  | first6=A  | last7=Miao  | first7=D  | last8=Huso  | first8=DL  | last9=Arceci  | first9=RJ }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |name-list-format=vanc| author2=Earthrowl ME  | author3=Grafham DV  | display-authors=3  | last4=Rubenfield  | first4=M.  | last5=French  | first5=L.  | last6=Steward  | first6=C. A.  | last7=Sims  | first7=S. K.  | last8=Jones  | first8=M. C.  | last9=Searle  | first9=S. }}
*{{cite journal  | author=Sun LQ, Lee DW, Zhang Q, ''et al.'' |title=Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. |journal=Genes Dev. |volume=18 |issue= 9 |pages= 1035-46 |year= 2004 |pmid= 15105378 |doi= 10.1101/gad.1176104 }}
*{{cite journal  | author=Yano M |title=Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer |journal=Int. J. Cancer |volume=112 |issue= 1 |pages= 8–13 |year= 2004 |pmid= 15305370 |doi= 10.1002/ijc.20407 |name-list-format=vanc| author2=Ouchida M  | author3=Shigematsu H  | display-authors=3  | last4=Tanaka  | first4=Noriyoshi  | last5=Ichimura  | first5=Koichi  | last6=Kobayashi  | first6=Kazuyasu  | last7=Inaki  | first7=Yasuhiko  | last8=Toyooka  | first8=Shinichi  | last9=Tsukuda  | first9=Kazunori }}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Yano M, Ouchida M, Shigematsu H, ''et al.'' |title=Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer. |journal=Int. J. Cancer |volume=112 |issue= 1 |pages= 8-13 |year= 2004 |pmid= 15305370 |doi= 10.1002/ijc.20407 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:11, 8 October 2018

For the anime film, see Hells Angels (manga).
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene.[1][2][3]

This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

References

  1. ↑ Geiman TM, Durum SK, Muegge K (Feb 1999). "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)". Genomics. 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.
  2. ↑ Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ (Aug 2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res. 60 (13): 3612–22. PMID 10910076.
  3. ↑ 3.0 3.1 "Entrez Gene: HELLS helicase, lymphoid-specific".

Further reading



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