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{{Infobox_gene}}
{{PBB_Controls
'''Ras-related protein R-Ras2''' is a [[protein]] that in humans is encoded by the ''RRAS2'' [[gene]].<ref name="pmid2108320">{{cite journal |vauthors=Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P | title = Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line | journal = Mol Cell Biol | volume = 10 | issue = 4 | pages = 1793–8 |date=May 1990 | pmid = 2108320 | pmc = 362288 | doi =  }}</ref><ref name="pmid8052619">{{cite journal |vauthors=Chan AM, Miki T, Meyers KA, Aaronson SA | title = A human oncogene of the RAS superfamily unmasked by expression cDNA cloning | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 16 | pages = 7558–62 |date=September 1994 | pmid = 8052619 | pmc = 44441 | doi =10.1073/pnas.91.16.7558 | bibcode =1994PNAS...91.7558C }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22800| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_RRAS2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ery.
| PDB = {{PDB2|2ery}}
| Name = Related RAS viral (r-ras) oncogene homolog 2
| HGNCid = 17271
| Symbol = RRAS2
| AltSymbols =; TC21
| OMIM = 600098
| ECnumber =
| Homologene = 6945
| MGIid = 1914172
| GeneAtlas_image1 = PBB_GE_RRAS2_212589_at_tn.png
| GeneAtlas_image2 = PBB_GE_RRAS2_208456_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RRAS2_212590_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
  | Process = {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22800
    | Hs_Ensembl = ENSG00000133818
    | Hs_RefseqProtein = NP_036382
    | Hs_RefseqmRNA = NM_012250
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 14256889
    | Hs_GenLoc_end = 14337289
    | Hs_Uniprot = P62070
    | Mm_EntrezGene = 66922
    | Mm_Ensembl = ENSMUSG00000055723
    | Mm_RefseqmRNA = NM_025846
    | Mm_RefseqProtein = NP_080122
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 113837969
    | Mm_GenLoc_end = 113908962
    | Mm_Uniprot = Q9CTF6
  }}
}}
'''Related RAS viral (r-ras) oncogene homolog 2''', also known as '''RRAS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22800| accessdate = }}</ref>


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| summary_text =  
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}}
==Interactions==
RRAS2 has been shown to [[Protein-protein interaction|interact]] with [[C-Raf]].<ref name=pmid10783161>{{cite journal |last=Li |first=W |authorlink= |author2=Han M |author3=Guan K L  |date=April 2000  |title=The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf |journal=Genes Dev. |volume=14 |issue=8 |pages=895–900 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 10783161 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=316541 }}</ref><ref name=pmid10557073>{{cite journal |last=Movilla |first=N |authorlink= |author2=Crespo P |author3=Bustelo X R  |date=October 1999  |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins |journal=Oncogene |volume=18 |issue=43 |pages=5860–9 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10557073 |doi = 10.1038/sj.onc.1202968 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089-106 |year= 2002 |pmid= 12384139 |doi=  }}
*{{cite journal  |vauthors=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089–106 |year= 2002 |pmid= 12384139 |doi=10.1016/S0301-472X(02)00904-9 }}
*{{cite journal  | author=Drivas GT, Shih A, Coutavas E, ''et al.'' |title=Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. |journal=Mol. Cell. Biol. |volume=10 |issue= 4 |pages= 1793-8 |year= 1990 |pmid= 2108320 |doi= }}
*{{cite journal  |vauthors=Rosário M, Paterson HF, Marshall CJ |title=Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1270–9 |year= 1999 |pmid= 10064593 |doi= 10.1093/emboj/18.5.1270  | pmc=1171217 }}
*{{cite journal | author=Chan AM, Miki T, Meyers KA, Aaronson SA |title=A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 16 |pages= 7558-62 |year= 1994 |pmid= 8052619 |doi=  }}
*{{cite journal   |vauthors=Linnemann T, Geyer M, Jaitner BK, etal |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556–62 |year= 1999 |pmid= 10224125 |doi=10.1074/jbc.274.19.13556 }}
*{{cite journal | author=Rosário M, Paterson HF, Marshall CJ |title=Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1270-9 |year= 1999 |pmid= 10064593 |doi= 10.1093/emboj/18.5.1270 }}
*{{cite journal   |vauthors=Ehrhardt GR, Leslie KB, Lee F, etal |title=M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. |journal=Blood |volume=94 |issue= 7 |pages= 2433–44 |year= 1999 |pmid= 10498616 |doi= }}
*{{cite journal  | author=Linnemann T, Geyer M, Jaitner BK, ''et al.'' |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556-62 |year= 1999 |pmid= 10224125 |doi= }}
*{{cite journal  |vauthors=Movilla N, Crespo P, Bustelo XR |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. |journal=Oncogene |volume=18 |issue= 43 |pages= 5860–9 |year= 1999 |pmid= 10557073 |doi= 10.1038/sj.onc.1202968 }}
*{{cite journal | author=Ehrhardt GR, Leslie KB, Lee F, ''et al.'' |title=M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. |journal=Blood |volume=94 |issue= 7 |pages= 2433-44 |year= 1999 |pmid= 10498616 |doi= }}
*{{cite journal   |vauthors=Ohba Y, Mochizuki N, Yamashita S, etal |title=Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20020–6 |year= 2000 |pmid= 10777492 |doi= 10.1074/jbc.M000981200 }}
*{{cite journal  | author=Movilla N, Crespo P, Bustelo XR |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. |journal=Oncogene |volume=18 |issue= 43 |pages= 5860-9 |year= 1999 |pmid= 10557073 |doi= 10.1038/sj.onc.1202968 }}
*{{cite journal  |vauthors=Figueroa C, Taylor J, Vojtek AB |title=Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28219–25 |year= 2001 |pmid= 11335720 |doi= 10.1074/jbc.M101763200 }}
*{{cite journal | author=Ohba Y, Mochizuki N, Yamashita S, ''et al.'' |title=Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20020-6 |year= 2000 |pmid= 10777492 |doi= 10.1074/jbc.M000981200 }}
*{{cite journal   |vauthors=Murphy GA, Graham SM, Morita S, etal |title=Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9966–75 |year= 2002 |pmid= 11788587 |doi= 10.1074/jbc.M109059200 }}
*{{cite journal | author=Figueroa C, Taylor J, Vojtek AB |title=Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28219-25 |year= 2001 |pmid= 11335720 |doi= 10.1074/jbc.M101763200 }}
*{{cite journal   |vauthors=Rong R, He Q, Liu Y, etal |title=TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. |journal=Oncogene |volume=21 |issue= 7 |pages= 1062–70 |year= 2002 |pmid= 11850823 |doi= 10.1038/sj.onc.1205154 }}
*{{cite journal | author=Murphy GA, Graham SM, Morita S, ''et al.'' |title=Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9966-75 |year= 2002 |pmid= 11788587 |doi= 10.1074/jbc.M109059200 }}
*{{cite journal   |vauthors=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, etal |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381–90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 }}
*{{cite journal | author=Rong R, He Q, Liu Y, ''et al.'' |title=TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. |journal=Oncogene |volume=21 |issue= 7 |pages= 1062-70 |year= 2002 |pmid= 11850823 |doi= 10.1038/sj.onc.1205154 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, ''et al.'' |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381-90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 }}
*{{cite journal  |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mitin NY, Ramocki MB, Zullo AJ, etal |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
*{{cite journal | author=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112-25 |year= 2003 |pmid= 12620389 |doi= }}
*{{cite journal   |vauthors=Kho Y, Kim SC, Jiang C, etal |title=A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 34 |pages= 12479–84 |year= 2004 |pmid= 15308774 |doi= 10.1073/pnas.0403413101  | pmc=515085 |bibcode=2004PNAS..10112479K }}
*{{cite journal | author=Mitin NY, Ramocki MB, Zullo AJ, ''et al.'' |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353-61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
*{{cite journal | author=Kho Y, Kim SC, Jiang C, ''et al.'' |title=A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 34 |pages= 12479-84 |year= 2004 |pmid= 15308774 |doi= 10.1073/pnas.0403413101 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=22800}}
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Latest revision as of 01:49, 26 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.[1][2][3]


Interactions

RRAS2 has been shown to interact with C-Raf.[4][5]

References

  1. Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. PMC 362288. PMID 2108320.
  2. Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A. 91 (16): 7558–62. Bibcode:1994PNAS...91.7558C. doi:10.1073/pnas.91.16.7558. PMC 44441. PMID 8052619.
  3. "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2".
  4. Li, W; Han M; Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. UNITED STATES. 14 (8): 895–900. ISSN 0890-9369. PMC 316541. PMID 10783161.
  5. Movilla, N; Crespo P; Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. ENGLAND. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073.

Further reading