ST3GAL4: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase''' is an [[enzyme]] that in humans is encoded by the ''ST3GAL4'' [[gene]].<ref name="pmid8557707">{{cite journal | vauthors = Kitagawa H, Mattei MG, Paulson JC | title = Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase | journal = J Biol Chem | volume = 271 | issue = 2 | pages = 931–8 |date=Feb 1996 | pmid = 8557707 | pmc =  | doi =10.1074/jbc.271.2.931 }}</ref><ref name="pmid8288606">{{cite journal | vauthors = Kitagawa H, Paulson JC | title = Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups | journal = J Biol Chem | volume = 269 | issue = 2 | pages = 1394–401 |date=Feb 1994 | pmid = 8288606 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6484| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = ST3 beta-galactoside alpha-2,3-sialyltransferase 4
| HGNCid = 10864
| Symbol = ST3GAL4
| AltSymbols =; CGS23; FLJ11867; NANTA3; SAT3; SIAT4; SIAT4C; ST3Gal IV; ST3GalIV; STZ
| OMIM = 104240
| ECnumber =
| Homologene = 4572
| MGIid = 1316743
  | GeneAtlas_image1 = PBB_GE_ST3GAL4_203759_at_tn.png
| GeneAtlas_image2 = PBB_GE_ST3GAL4_215710_at_tn.png
  | Function = {{GNF_GO|id=GO:0003836 |text = beta-galactoside alpha-2,3-sialyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030173 |text = integral to Golgi membrane}}
  | Process = {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6484
    | Hs_Ensembl = ENSG00000110080
    | Hs_RefseqProtein = NP_006269
    | Hs_RefseqmRNA = NM_006278
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 125730765
    | Hs_GenLoc_end = 125815962
    | Hs_Uniprot = Q11206
    | Mm_EntrezGene = 20443
    | Mm_Ensembl = ENSMUSG00000032038
    | Mm_RefseqmRNA = NM_009178
    | Mm_RefseqProtein = NP_033204
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 34796247
    | Mm_GenLoc_end = 34866481
    | Mm_Uniprot = P97354
  }}
}}
'''ST3 beta-galactoside alpha-2,3-sialyltransferase 4''', also known as '''ST3GAL4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6484| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kalyanaraman VS, Rodriguez V, Veronese F, ''et al.'' |title=Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. |journal=AIDS Res. Hum. Retroviruses |volume=6 |issue= 3 |pages= 371-80 |year= 1990 |pmid= 2187500 |doi=  }}
*{{cite journal   |vauthors=Kalyanaraman VS, Rodriguez V, Veronese F, etal |title=Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 |journal=AIDS Res. Hum. Retroviruses |volume=6 |issue= 3 |pages= 371–80 |year= 1990 |pmid= 2187500 |doi=10.1089/aid.1990.6.371 }}
*{{cite journal  | author=Pal R, Hoke GM, Sarngadharan MG |title=Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 9 |pages= 3384-8 |year= 1989 |pmid= 2541446 |doi= }}
*{{cite journal  | vauthors=Pal R, Hoke GM, Sarngadharan MG |title=Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 9 |pages= 3384–8 |year= 1989 |pmid= 2541446 |doi=10.1073/pnas.86.9.3384  | pmc=287137  }}
*{{cite journal  | author=Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP |title=Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport. |journal=J. Virol. |volume=63 |issue= 6 |pages= 2452-6 |year= 1989 |pmid= 2542563 |doi=  }}
*{{cite journal  | vauthors=Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP |title=Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport |journal=J. Virol. |volume=63 |issue= 6 |pages= 2452–6 |year= 1989 |pmid= 2542563 |doi= | pmc=250699 }}
*{{cite journal | author=Kozarsky K, Penman M, Basiripour L, ''et al.'' |title=Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein. |journal=J. Acquir. Immune Defic. Syndr. |volume=2 |issue= 2 |pages= 163-9 |year= 1989 |pmid= 2649653 |doi=  }}
*{{cite journal   |vauthors=Kozarsky K, Penman M, Basiripour L, etal |title=Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein |journal=J. Acquir. Immune Defic. Syndr. |volume=2 |issue= 2 |pages= 163–9 |year= 1989 |pmid= 2649653 |doi=  }}
*{{cite journal  | author=Robinson WE, Montefiori DC, Mitchell WM |title=Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. |journal=AIDS Res. Hum. Retroviruses |volume=3 |issue= 3 |pages= 265-82 |year= 1988 |pmid= 2829950 |doi=  }}
*{{cite journal  | vauthors=Robinson WE, Montefiori DC, Mitchell WM |title=Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis |journal=AIDS Res. Hum. Retroviruses |volume=3 |issue= 3 |pages= 265–82 |year= 1988 |pmid= 2829950 |doi=10.1089/aid.1987.3.265 }}
*{{cite journal  | author=Munro S |title=An investigation of the role of transmembrane domains in Golgi protein retention. |journal=EMBO J. |volume=14 |issue= 19 |pages= 4695-704 |year= 1995 |pmid= 7588599 |doi=  }}
*{{cite journal  | author=Munro S |title=An investigation of the role of transmembrane domains in Golgi protein retention |journal=EMBO J. |volume=14 |issue= 19 |pages= 4695–704 |year= 1995 |pmid= 7588599 |doi= | pmc=394566 }}
*{{cite journal  | author=Chang ML, Eddy RL, Shows TB, Lau JT |title=Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies. |journal=Glycobiology |volume=5 |issue= 3 |pages= 319-25 |year= 1995 |pmid= 7655169 |doi= }}
*{{cite journal  | vauthors=Chang ML, Eddy RL, Shows TB, Lau JT |title=Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies |journal=Glycobiology |volume=5 |issue= 3 |pages= 319–25 |year= 1995 |pmid= 7655169 |doi=10.1093/glycob/5.3.319  }}
*{{cite journal | author=Sasaki K, Watanabe E, Kawashima K, ''et al.'' |title=Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22782-7 |year= 1993 |pmid= 7901202 |doi=  }}
*{{cite journal   |vauthors=Sasaki K, Watanabe E, Kawashima K, etal |title=Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22782–7 |year= 1993 |pmid= 7901202 |doi=  }}
*{{cite journal  | author=Kitagawa H, Paulson JC |title=Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1394-401 |year= 1994 |pmid= 8288606 |doi= }}
*{{cite journal  | vauthors=Basu SS, Basu M, Li Z, Basu S |title=Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line |journal=Biochemistry |volume=35 |issue= 16 |pages= 5166–74 |year= 1996 |pmid= 8611500 |doi= 10.1021/bi960239l }}
*{{cite journal | author=Kitagawa H, Mattei MG, Paulson JC |title=Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 931-8 |year= 1996 |pmid= 8557707 |doi=  }}
*{{cite journal   |vauthors=Saito S, Yamashita S, Endoh M, etal |title=Clinical significance of ST3Gal IV expression in human renal cell carcinoma |journal=Oncol. Rep. |volume=9 |issue= 6 |pages= 1251–5 |year= 2003 |pmid= 12375029 |doi=  10.3892/or.9.6.1251}}
*{{cite journal  | author=Basu SS, Basu M, Li Z, Basu S |title=Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. |journal=Biochemistry |volume=35 |issue= 16 |pages= 5166-74 |year= 1996 |pmid= 8611500 |doi= 10.1021/bi960239l }}
*{{cite journal  | vauthors=Grahn A, Larson G |title=Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues |journal=Glycoconj. J. |volume=18 |issue= 10 |pages= 759–67 |year= 2003 |pmid= 12441665 |doi=10.1023/A:1021199300718  }}
*{{cite journal | author=Saito S, Yamashita S, Endoh M, ''et al.'' |title=Clinical significance of ST3Gal IV expression in human renal cell carcinoma. |journal=Oncol. Rep. |volume=9 |issue= 6 |pages= 1251-5 |year= 2003 |pmid= 12375029 |doi= }}
*{{cite journal   |vauthors=Moody AM, North SJ, Reinhold B, etal |title=Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7240–6 |year= 2003 |pmid= 12459555 |doi= 10.1074/jbc.M210468200 }}
*{{cite journal | author=Grahn A, Larson G |title=Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues. |journal=Glycoconj. J. |volume=18 |issue= 10 |pages= 759-67 |year= 2003 |pmid= 12441665 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Moody AM, North SJ, Reinhold B, ''et al.'' |title=Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7240-6 |year= 2003 |pmid= 12459555 |doi= 10.1074/jbc.M210468200 }}
*{{cite journal  | vauthors=Taniguchi A, Hioki M, Matsumoto K |title=Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 764–8 |year= 2003 |pmid= 12565846 |doi=10.1016/S0006-291X(03)00041-X  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Taniguchi A, Hioki M, Matsumoto K |title=Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 764-8 |year= 2003 |pmid= 12565846 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Higai K, Miyazaki N, Azuma Y, Matsumoto K |title=Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6069–75 |year= 2007 |pmid= 17054948 |doi= 10.1016/j.febslet.2006.09.073 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Szabo R, Skropeta D, etal |title=Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities. |journal=Med. Res. Rev. |volume=37 |pages= 210–270 |year= 2017 |doi= 10.1002/med.21407 }}
*{{cite journal  | author=Higai K, Miyazaki N, Azuma Y, Matsumoto K |title=Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6069-75 |year= 2007 |pmid= 17054948 |doi= 10.1016/j.febslet.2006.09.073 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-11-stub}}

Latest revision as of 21:38, 20 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.[1][2][3]


References

  1. Kitagawa H, Mattei MG, Paulson JC (Feb 1996). "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase". J Biol Chem. 271 (2): 931–8. doi:10.1074/jbc.271.2.931. PMID 8557707.
  2. Kitagawa H, Paulson JC (Feb 1994). "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups". J Biol Chem. 269 (2): 1394–401. PMID 8288606.
  3. "Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4".

Further reading