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{{Infobox_gene}}
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'''Retinoic acid receptor responder protein 3''' is a [[protein]] that in humans is encoded by the ''RARRES3'' [[gene]].<ref name="pmid9270552">{{cite journal |vauthors=Duvic M, Nagpal S, Asano AT, Chandraratna RA | title = Molecular mechanisms of tazarotene action in psoriasis | journal = J Am Acad Dermatol | volume = 37 | issue = 2 Pt 3 | pages = S18–24 |date=Sep 1997 | pmid = 9270552 | pmc =  | doi =  10.1016/s0190-9622(97)80396-9}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5920| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Retinoic acid receptor responder (tazarotene induced) 3
| HGNCid = 9869
| Symbol = RARRES3
| AltSymbols =; HRASLS4; MGC8906; RIG1; TIG3
| OMIM = 605092
| ECnumber = 
| Homologene = 48290
| MGIid = 
| GeneAtlas_image1 = PBB_GE_RARRES3_204070_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5920
    | Hs_Ensembl = ENSG00000133321
    | Hs_RefseqProtein = NP_004576
    | Hs_RefseqmRNA = NM_004585
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 63060856
    | Hs_GenLoc_end = 63070505
    | Hs_Uniprot = Q9UL19
    | Mm_EntrezGene =
    | Mm_Ensembl =   
    | Mm_RefseqmRNA =   
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
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'''Retinoic acid receptor responder (tazarotene induced) 3''', also known as '''RARRES3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5920| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.<ref name="entrez">{{cite web | title = Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5920| accessdate = }}</ref>
| summary_text = Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.<ref name="entrez"/>
}}
}}
==Interactions==
RARRES3 has been shown to [[Protein-protein interaction|interact]] with [[RNF135]].<ref name=pmid19017631>{{cite journal |last=Oshiumi |first=Hiroyuki |authorlink= |author2=Matsumoto Misako |author3=Hatakeyama Shigetsugu |author4=Seya Tsukasa  |date=Jan 2009 |title=Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection |journal=J. Biol. Chem. |volume=284 |issue=2 |pages=807–17 |publisher= |location = United States| issn = 0021-9258| pmid = 19017631 |doi = 10.1074/jbc.M804259200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Duvic M, Nagpal S, Asano AT, Chandraratna RA |title=Molecular mechanisms of tazarotene action in psoriasis. |journal=J. Am. Acad. Dermatol. |volume=37 |issue= 2 Pt 3 |pages= S18-24 |year= 1997 |pmid= 9270552 |doi= }}
*{{cite journal   |vauthors=Nagpal S, Patel S, Jacobe H, etal |title=Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. |journal=J. Invest. Dermatol. |volume=109 |issue= 1 |pages= 91–5 |year= 1997 |pmid= 9204961 |doi=10.1111/1523-1747.ep12276660  }}
*{{cite journal | author=Nagpal S, Patel S, Jacobe H, ''et al.'' |title=Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. |journal=J. Invest. Dermatol. |volume=109 |issue= 1 |pages= 91-5 |year= 1997 |pmid= 9204961 |doi= }}
*{{cite journal   |vauthors=DiSepio D, Ghosn C, Eckert RL, etal |title=Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14811–5 |year= 1999 |pmid= 9843971 |doi=10.1073/pnas.95.25.14811  | pmc=24531  |bibcode=1998PNAS...9514811D }}
*{{cite journal  | author=DiSepio D, Ghosn C, Eckert RL, ''et al.'' |title=Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14811-5 |year= 1999 |pmid= 9843971 |doi=  }}
*{{cite journal  |vauthors=Huang SL, Shyu RY, Yeh MY, Jiang SY |title=Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. |journal=Mol. Cell. Endocrinol. |volume=159 |issue= 1–2 |pages= 15–24 |year= 2000 |pmid= 10687848 |doi=10.1016/S0303-7207(99)00207-5 }}
*{{cite journal | author=Huang SL, Shyu RY, Yeh MY, Jiang SY |title=Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. |journal=Mol. Cell. Endocrinol. |volume=159 |issue= 1-2 |pages= 15-24 |year= 2000 |pmid= 10687848 |doi=  }}
*{{cite journal   |vauthors=Duvic M, Helekar B, Schulz C, etal |title=Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer |journal=Clin. Cancer Res. |volume=6 |issue= 8 |pages= 3249–59 |year= 2000 |pmid= 10955811 |doi=  }}
*{{cite journal | author=Duvic M, Helekar B, Schulz C, ''et al.'' |title=Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer. |journal=Clin. Cancer Res. |volume=6 |issue= 8 |pages= 3249-59 |year= 2000 |pmid= 10955811 |doi=  }}
*{{cite journal   |vauthors=Deucher A, Nagpal S, Chandraratna RA, etal |title=The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity |journal=Int. J. Oncol. |volume=17 |issue= 6 |pages= 1195–203 |year= 2001 |pmid= 11078805 |doi=  10.3892/ijo.17.6.1195}}
*{{cite journal | author=Deucher A, Nagpal S, Chandraratna RA, ''et al.'' |title=The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity. |journal=Int. J. Oncol. |volume=17 |issue= 6 |pages= 1195-203 |year= 2001 |pmid= 11078805 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Higuchi E, Chandraratna RA, Hong WK, Lotan R |title=Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype |journal=Oncogene |volume=22 |issue= 30 |pages= 4627–35 |year= 2003 |pmid= 12879006 |doi= 10.1038/sj.onc.1206235 }}
*{{cite journal | author=Higuchi E, Chandraratna RA, Hong WK, Lotan R |title=Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype. |journal=Oncogene |volume=22 |issue= 30 |pages= 4627-35 |year= 2003 |pmid= 12879006 |doi= 10.1038/sj.onc.1206235 }}
*{{cite journal   |vauthors=Sturniolo MT, Dashti SR, Deucher A, etal |title=A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48066–73 |year= 2004 |pmid= 12928434 |doi= 10.1074/jbc.M307215200 }}
*{{cite journal | author=Sturniolo MT, Dashti SR, Deucher A, ''et al.'' |title=A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48066-73 |year= 2004 |pmid= 12928434 |doi= 10.1074/jbc.M307215200 }}
*{{cite journal   |vauthors=Yoneyama M, Kikuchi M, Natsukawa T, etal |title=The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses |journal=Nat. Immunol. |volume=5 |issue= 7 |pages= 730–7 |year= 2004 |pmid= 15208624 |doi= 10.1038/ni1087 }}
*{{cite journal | author=Yoneyama M, Kikuchi M, Natsukawa T, ''et al.'' |title=The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. |journal=Nat. Immunol. |volume=5 |issue= 7 |pages= 730-7 |year= 2004 |pmid= 15208624 |doi= 10.1038/ni1087 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Jiang SY, Chou JM, Leu FJ, etal |title=Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma |journal=World J. Gastroenterol. |volume=11 |issue= 7 |pages= 948–53 |year= 2005 |pmid= 15742394 |doi= }}
*{{cite journal  | author=Jiang SY, Chou JM, Leu FJ, ''et al.'' |title=Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma. |journal=World J. Gastroenterol. |volume=11 |issue= 7 |pages= 948-53 |year= 2005 |pmid= 15742394 |doi= }}
*{{cite journal  |vauthors=Sturniolo MT, Chandraratna RA, Eckert RL |title=A novel transglutaminase activator forms a complex with type 1 transglutaminase |journal=Oncogene |volume=24 |issue= 18 |pages= 2963–72 |year= 2005 |pmid= 15846304 |doi= 10.1038/sj.onc.1208392 }}
*{{cite journal | author=Sturniolo MT, Chandraratna RA, Eckert RL |title=A novel transglutaminase activator forms a complex with type 1 transglutaminase. |journal=Oncogene |volume=24 |issue= 18 |pages= 2963-72 |year= 2005 |pmid= 15846304 |doi= 10.1038/sj.onc.1208392 }}
*{{cite journal   |vauthors=Jiang SY, Wu MS, Chen LM, etal |title=Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 2 |pages= 630–9 |year= 2005 |pmid= 15850806 |doi= 10.1016/j.bbrc.2005.03.214 }}
*{{cite journal | author=Jiang SY, Wu MS, Chen LM, ''et al.'' |title=Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 2 |pages= 630-9 |year= 2005 |pmid= 15850806 |doi= 10.1016/j.bbrc.2005.03.214 }}
*{{cite journal   |vauthors=Lotz K, Kellner T, Heitmann M, etal |title=Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms |journal=Int. J. Cancer |volume=116 |issue= 6 |pages= 894–902 |year= 2005 |pmid= 15856468 |doi= 10.1002/ijc.21127 }}
*{{cite journal | author=Lotz K, Kellner T, Heitmann M, ''et al.'' |title=Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms. |journal=Int. J. Cancer |volume=116 |issue= 6 |pages= 894-902 |year= 2005 |pmid= 15856468 |doi= 10.1002/ijc.21127 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Guo Z, Chen LM, Zeng H, etal |title=NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I |journal=Am. J. Respir. Cell Mol. Biol. |volume=36 |issue= 3 |pages= 263–9 |year= 2007 |pmid= 17053203 |doi= 10.1165/rcmb.2006-0283RC }}
*{{cite journal | author=Guo Z, Chen LM, Zeng H, ''et al.'' |title=NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I. |journal=Am. J. Respir. Cell Mol. Biol. |volume=36 |issue= 3 |pages= 263-9 |year= 2007 |pmid= 17053203 |doi= 10.1165/rcmb.2006-0283RC }}
*{{cite journal   |vauthors=Chen Z, Benureau Y, Rijnbrand R, etal |title=GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS |journal=J. Virol. |volume=81 |issue= 2 |pages= 964–76 |year= 2007 |pmid= 17093192 |doi= 10.1128/JVI.02076-06 | pmc=1797450 }}
*{{cite journal | author=Chen Z, Benureau Y, Rijnbrand R, ''et al.'' |title=GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. |journal=J. Virol. |volume=81 |issue= 2 |pages= 964-76 |year= 2007 |pmid= 17093192 |doi= 10.1128/JVI.02076-06 }}
*{{cite journal  |vauthors=Tsai FM, Shyu RY, Jiang SY |title=RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus |journal=Cell. Signal. |volume=19 |issue= 5 |pages= 989–99 |year= 2007 |pmid= 17196792 |doi= 10.1016/j.cellsig.2006.11.005 }}
*{{cite journal  | author=Tsai FM, Shyu RY, Jiang SY |title=RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. |journal=Cell. Signal. |volume=19 |issue= 5 |pages= 989-99 |year= 2007 |pmid= 17196792 |doi= 10.1016/j.cellsig.2006.11.005 }}
}}
}}
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Latest revision as of 01:36, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.[1][2]

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.[2]

Interactions

RARRES3 has been shown to interact with RNF135.[3]

References

  1. ↑ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.
  2. ↑ 2.0 2.1 "Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3".
  3. ↑ Oshiumi, Hiroyuki; Matsumoto Misako; Hatakeyama Shigetsugu; Seya Tsukasa (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J. Biol. Chem. United States. 284 (2): 807–17. doi:10.1074/jbc.M804259200. ISSN 0021-9258. PMID 19017631.

Further reading



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