RAB1B: Difference between revisions

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{{Infobox_gene}}
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'''Ras-related protein Rab-1B''' is a [[protein]] that in humans is encoded by the ''RAB1B'' [[gene]].<ref name="pmid9030196">{{cite journal |vauthors=Chen D, Guo J, Gahl WA | title = RAB GTPases expressed in human melanoma cells | journal = Biochim Biophys Acta | volume = 1355 | issue = 1 | pages = 1–6 |date=March 1997 | pmid = 9030196 | pmc =  | doi =10.1016/S0167-4889(96)00169-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB1B RAB1B, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81876| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_RAB1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fol.
| PDB = {{PDB2|2fol}}
| Name = RAB1B, member RAS oncogene family
| HGNCid = 18370
| Symbol = RAB1B
| AltSymbols =;
| OMIM =
| ECnumber =
| Homologene = 49926
| MGIid = 1923558
| GeneAtlas_image1 = PBB_GE_RAB1B_220964_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 81876
    | Hs_Ensembl = ENSG00000174903
    | Hs_RefseqProtein = XP_001134089
    | Hs_RefseqmRNA = XM_001134089
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 65792681
    | Hs_GenLoc_end = 65801537
    | Hs_Uniprot = Q9H0U4
    | Mm_EntrezGene = 76308
    | Mm_Ensembl = ENSMUSG00000024870
    | Mm_RefseqmRNA = NM_029576
    | Mm_RefseqProtein = NP_083852
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5099207
    | Mm_GenLoc_end = 5106996
    | Mm_Uniprot = Q0PD66
  }}
}}
'''RAB1B, member RAS oncogene family''', also known as '''RAB1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB1B RAB1B, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81876| accessdate = }}</ref>


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==Interactions==
RAB1B has been shown to [[Protein-protein interaction|interact]] with [[GOLGA2]].<ref name=pmid11306556>{{cite journal |last=Weide |first=T |authorlink= |author2=Bayer M |author3=Köster M |author4=Siebrasse J P |author5=Peters R |author6=Barnekow A  |date=April 2001 |title=The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b |journal=EMBO Rep. |volume=2 |issue=4 |pages=336–41 |publisher= |location = England| issn = 1469-221X| pmid = 11306556 |doi = 10.1093/embo-reports/kve065 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1083862 }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Plutner H, Cox AD, Pind S, ''et al.'' |title=Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. |journal=J. Cell Biol. |volume=115 |issue= 1 |pages= 31-43 |year= 1991 |pmid= 1918138 |doi=  }}
*{{cite journal   |vauthors=Plutner H, Cox AD, Pind S, etal |title=Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments |journal=J. Cell Biol. |volume=115 |issue= 1 |pages= 31–43 |year= 1991 |pmid= 1918138 |doi=10.1083/jcb.115.1.31  | pmc=2289927 }}
*{{cite journal  | author=Soldati T, Rancaño C, Geissler H, Pfeffer SR |title=Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25541-8 |year= 1995 |pmid= 7592724 |doi= }}
*{{cite journal  |vauthors=Soldati T, Rancaño C, Geissler H, Pfeffer SR |title=Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25541–8 |year= 1995 |pmid= 7592724 |doi=10.1074/jbc.270.43.25541  |url=https://archive-ouverte.unige.ch/unige:18935/ATTACHMENT01 }}
*{{cite journal  | author=Wilson AL, Sheridan KM, Erdman RA, Maltese WA |title=Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. |journal=Biochem. J. |volume=318 ( Pt 3) |issue=  |pages= 1007-14 |year= 1996 |pmid= 8836150 |doi=  }}
*{{cite journal  |vauthors=Wilson AL, Sheridan KM, Erdman RA, Maltese WA |title=Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells |journal=Biochem. J. |volume=318 |issue=  Pt 3|pages= 1007–14 |year= 1996 |pmid= 8836150 |doi= 10.1042/bj3181007| pmc=1217717 }}
*{{cite journal  | author=Chen D, Guo J, Gahl WA |title=RAB GTPases expressed in human melanoma cells. |journal=Biochim. Biophys. Acta |volume=1355 |issue= 1 |pages= 1-6 |year= 1997 |pmid= 9030196 |doi=  }}
*{{cite journal  |vauthors=Overmeyer JH, Wilson AL, Erdman RA, Maltese WA |title=The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein |journal=Mol. Biol. Cell |volume=9 |issue= 1 |pages= 223–35 |year= 1998 |pmid= 9437002 |doi=  10.1091/mbc.9.1.223| pmc=25245  }}
*{{cite journal  | author=Overmeyer JH, Wilson AL, Erdman RA, Maltese WA |title=The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. |journal=Mol. Biol. Cell |volume=9 |issue= 1 |pages= 223-35 |year= 1998 |pmid= 9437002 |doi=  }}
*{{cite journal  |vauthors=Weide T, Koster M, Barnekow A |title=Inactive and active mutants of rab1b are not tightly integrated into target membranes |journal=Int. J. Oncol. |volume=15 |issue= 4 |pages= 727–36 |year= 1999 |pmid= 10493955 |doi=  10.3892/ijo.15.4.727}}
*{{cite journal  | author=Weide T, Koster M, Barnekow A |title=Inactive and active mutants of rab1b are not tightly integrated into target membranes. |journal=Int. J. Oncol. |volume=15 |issue= 4 |pages= 727-36 |year= 1999 |pmid= 10493955 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Weide T, Bayer M, Köster M, etal |title=The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b |journal=EMBO Rep. |volume=2 |issue= 4 |pages= 336–41 |year= 2001 |pmid= 11306556 |doi= 10.1093/embo-reports/kve065  | pmc=1083862 }}
*{{cite journal  | author=Weide T, Bayer M, Köster M, ''et al.'' |title=The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b. |journal=EMBO Rep. |volume=2 |issue= 4 |pages= 336-41 |year= 2001 |pmid= 11306556 |doi= 10.1093/embo-reports/kve065 }}
*{{cite journal  |vauthors=Zhao H, Ettala O, Väänänen HK |title=Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1060–5 |year= 2002 |pmid= 12051767 |doi= 10.1016/S0006-291X(02)00326-1 }}
*{{cite journal | author=Zhao H, Ettala O, Väänänen HK |title=Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1060-5 |year= 2002 |pmid= 12051767 |doi= 10.1016/S0006-291X(02)00326-1 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  |vauthors=Fischer J, Weide T, Barnekow A |title=The MICAL proteins and rab1: a possible link to the cytoskeleton? |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 415–23 |year= 2005 |pmid= 15694364 |doi= 10.1016/j.bbrc.2004.12.182 }}
*{{cite journal | author=Fischer J, Weide T, Barnekow A |title=The MICAL proteins and rab1: a possible link to the cytoskeleton? |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 415-23 |year= 2005 |pmid= 15694364 |doi= 10.1016/j.bbrc.2004.12.182 }}
*{{cite journal   |vauthors=Bayer M, Fischer J, Kremerskothen J, etal |title=Identification and characterization of Iporin as a novel interaction partner for rab1 |journal=BMC Cell Biol. |volume=6 |pages= 15 |year= 2006 |pmid= 15796781 |doi= 10.1186/1471-2121-6-15  | pmc=1079803 }}
*{{cite journal | author=Bayer M, Fischer J, Kremerskothen J, ''et al.'' |title=Identification and characterization of Iporin as a novel interaction partner for rab1. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 15 |year= 2006 |pmid= 15796781 |doi= 10.1186/1471-2121-6-15 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  |vauthors=Monetta P, Slavin I, Romero N, Alvarez C |title=Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association |journal=Mol. Biol. Cell |volume=18 |issue= 7 |pages= 2400–10 |year= 2007 |pmid= 17429068 |doi= 10.1091/mbc.E06-11-1005  | pmc=1924811 }}
*{{cite journal  | author=Monetta P, Slavin I, Romero N, Alvarez C |title=Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association. |journal=Mol. Biol. Cell |volume=18 |issue= 7 |pages= 2400-10 |year= 2007 |pmid= 17429068 |doi= 10.1091/mbc.E06-11-1005 }}
*{{cite journal  |vauthors=Machner MP, Isberg RR |title=A bifunctional bacterial protein links GDI displacement to Rab1 activation |journal=Science |volume=318 |issue= 5852 |pages= 974–7 |year= 2007 |pmid= 17947549 |doi= 10.1126/science.1149121 |bibcode=2007Sci...318..974M }}
*{{cite journal  | author=Machner MP, Isberg RR |title=A bifunctional bacterial protein links GDI displacement to Rab1 activation. |journal=Science |volume=318 |issue= 5852 |pages= 974-7 |year= 2007 |pmid= 17947549 |doi= 10.1126/science.1149121 }}
}}
}}
{{refend}}
{{Refend}}
{{PDB Gallery|geneid=81876}}
 
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{{protein-stub}}
{{Gene-11-stub}}
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Latest revision as of 12:19, 4 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.[1][2]


Interactions

RAB1B has been shown to interact with GOLGA2.[3]

References

  1. Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
  2. "Entrez Gene: RAB1B RAB1B, member RAS oncogene family".
  3. Weide, T; Bayer M; Köster M; Siebrasse J P; Peters R; Barnekow A (April 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. England. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862. PMID 11306556.

Further reading