PGA5: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Pepsin A''' is a [[protein]] that in humans is encoded by the ''PGA5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PGA5 pepsinogen 5, group I (pepsinogen A)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5222| accessdate = }}</ref>
| image = PBB_Protein_PGA5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1flh.
| PDB = {{PDB2|1flh}}, {{PDB2|1psn}}, {{PDB2|1pso}}, {{PDB2|1qrp}}
| Name = Pepsinogen 5, group I (pepsinogen A)
| HGNCid = 8887
| Symbol = PGA5
| AltSymbols =;
| OMIM = 169730
| ECnumber = 
| Homologene = 68135
| MGIid = 
| GeneAtlas_image1 = PBB_GE_PGA5_213265_at_tn.png
| Function = {{GNF_GO|id=GO:0004194 |text = pepsin A activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5222
    | Hs_Ensembl = ENSG00000172647
    | Hs_RefseqProtein = NP_055039
    | Hs_RefseqmRNA = NM_014224
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 60765225
    | Hs_GenLoc_end = 60775495
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Pepsinogen 5, group I (pepsinogen A)''', also known as '''PGA5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PGA5 pepsinogen 5, group I (pepsinogen A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5222| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Ichinose M, Miki K, Wong RN, ''et al.'' |title=Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer. |journal=Jpn. J. Cancer Res. |volume=82 |issue= 6 |pages= 686-92 |year= 1991 |pmid= 1906854 |doi=  }}
*{{cite journal   |vauthors=Ichinose M, Miki K, Wong RN, etal |title=Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer. |journal=Jpn. J. Cancer Res. |volume=82 |issue= 6 |pages= 686–92 |year= 1991 |pmid= 1906854 |pmc=5918501 |doi=  10.1111/j.1349-7006.1991.tb01904.x}}
*{{cite journal  | author=Ichihara Y, Sogawa K, Takahashi K |title=Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences. |journal=J. Biochem. |volume=98 |issue= 2 |pages= 483-92 |year= 1986 |pmid= 2415509 |doi=  }}
*{{cite journal  | vauthors=Ichihara Y, Sogawa K, Takahashi K |title=Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences. |journal=J. Biochem. |volume=98 |issue= 2 |pages= 483–92 |year= 1986 |pmid= 2415509 |doi=  }}
*{{cite journal  | author=Athauda SB, Tanji M, Kageyama T, Takahashi K |title=A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. |journal=J. Biochem. |volume=106 |issue= 5 |pages= 920-7 |year= 1990 |pmid= 2515193 |doi=  }}
*{{cite journal  | vauthors=Athauda SB, Tanji M, Kageyama T, Takahashi K |title=A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. |journal=J. Biochem. |volume=106 |issue= 5 |pages= 920–7 |year= 1990 |pmid= 2515193 |doi=  }}
*{{cite journal  | author=Hengels KJ, Strohmeyer G |title=Pepsinogens A and C: purification from human gastric mucosa and determination in serum by optimized radioimmunoassays. |journal=Zeitschrift für Gastroenterologie |volume=27 |issue= 8 |pages= 406-11 |year= 1990 |pmid= 2609705 |doi=  }}
*{{cite journal  | vauthors=Hengels KJ, Strohmeyer G |title=Pepsinogens A and C: purification from human gastric mucosa and determination in serum by optimized radioimmunoassays. |journal=Zeitschrift für Gastroenterologie |volume=27 |issue= 8 |pages= 406–11 |year= 1990 |pmid= 2609705 |doi=  }}
*{{cite journal | author=Evers MP, Zelle B, Bebelman JP, ''et al.'' |title=Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. |journal=Genomics |volume=4 |issue= 3 |pages= 232-9 |year= 1989 |pmid= 2714789 |doi=  }}
*{{cite journal   |vauthors=Evers MP, Zelle B, Bebelman JP, etal |title=Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. |journal=Genomics |volume=4 |issue= 3 |pages= 232–9 |year= 1989 |pmid= 2714789 |doi=10.1016/0888-7543(89)90325-X }}
*{{cite journal | author=ten Kate RW, Pals G, Donker AJ, ''et al.'' |title=Tubular handling of pepsinogen A and C in man: evidence for two distinct tubular reabsorption mechanisms for low molecular weight proteins in man. |journal=Nephron |volume=53 |issue= 3 |pages= 223-8 |year= 1989 |pmid= 2797342 |doi=  }}
*{{cite journal   |vauthors=ten Kate RW, Pals G, Donker AJ, etal |title=Tubular handling of pepsinogen A and C in man: evidence for two distinct tubular reabsorption mechanisms for low molecular weight proteins in man. |journal=Nephron |volume=53 |issue= 3 |pages= 223–8 |year= 1989 |pmid= 2797342 |doi=10.1159/000185748 }}
*{{cite journal | author=ten Kate RW, Pals G, Eriksson AW, ''et al.'' |title=The renal metabolism of pepsinogen A and C in man. |journal=Clin. Nephrol. |volume=31 |issue= 2 |pages= 103-6 |year= 1989 |pmid= 2920466 |doi=  }}
*{{cite journal   |vauthors=ten Kate RW, Pals G, Eriksson AW, etal |title=The renal metabolism of pepsinogen A and C in man. |journal=Clin. Nephrol. |volume=31 |issue= 2 |pages= 103–6 |year= 1989 |pmid= 2920466 |doi=  }}
*{{cite journal | author=Evers MP, Zelle B, Peeper DS, ''et al.'' |title=Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide. |journal=Hum. Genet. |volume=77 |issue= 2 |pages= 182-7 |year= 1987 |pmid= 3115885 |doi=  }}
*{{cite journal   |vauthors=Evers MP, Zelle B, Peeper DS, etal |title=Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide. |journal=Hum. Genet. |volume=77 |issue= 2 |pages= 182–7 |year= 1987 |pmid= 3115885 |doi=10.1007/BF00272389 }}
*{{cite journal | author=Pals G, Eriksson AW, Pronk JC, ''et al.'' |title=Differential expression of pepsinogen isozymogens in a patient with Barrett esophagus. |journal=Clin. Genet. |volume=34 |issue= 2 |pages= 90-7 |year= 1989 |pmid= 3191614 |doi=  }}
*{{cite journal   |vauthors=Pals G, Eriksson AW, Pronk JC, etal |title=Differential expression of pepsinogen isozymogens in a patient with Barrett esophagus. |journal=Clin. Genet. |volume=34 |issue= 2 |pages= 90–7 |year= 1989 |pmid= 3191614 |doi=10.1111/j.1399-0004.1988.tb02842.x }}
*{{cite journal  | author=Foltmann B |title=Activation of human pepsinogens. |journal=FEBS Lett. |volume=241 |issue= 1-2 |pages= 69-72 |year= 1989 |pmid= 3197840 |doi=  }}
*{{cite journal  | author=Foltmann B |title=Activation of human pepsinogens. |journal=FEBS Lett. |volume=241 |issue= 1–2 |pages= 69–72 |year= 1989 |pmid= 3197840 |doi=10.1016/0014-5793(88)81033-0 }}
*{{cite journal | author=Westerveld BD, Pals G, Bosma A, ''et al.'' |title=Gastric proteases in Barrett's esophagus. |journal=Gastroenterology |volume=93 |issue= 4 |pages= 774-8 |year= 1987 |pmid= 3305135 |doi=  }}
*{{cite journal   |vauthors=Westerveld BD, Pals G, Bosma A, etal |title=Gastric proteases in Barrett's esophagus. |journal=Gastroenterology |volume=93 |issue= 4 |pages= 774–8 |year= 1987 |pmid= 3305135 |doi=  }}
*{{cite journal  | author=Nakai H, Byers MG, Shows TB, Taggart RT |title=Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=43 |issue= 3-4 |pages= 215-7 |year= 1987 |pmid= 3467902 |doi=  }}
*{{cite journal  | vauthors=Nakai H, Byers MG, Shows TB, Taggart RT |title=Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=43 |issue= 3–4 |pages= 215–7 |year= 1987 |pmid= 3467902 |doi=10.1159/000132324 }}
*{{cite journal | author=Sogawa K, Fujii-Kuriyama Y, Mizukami Y, ''et al.'' |title=Primary structure of human pepsinogen gene. |journal=J. Biol. Chem. |volume=258 |issue= 8 |pages= 5306-11 |year= 1983 |pmid= 6300126 |doi=  }}
*{{cite journal   |vauthors=Sogawa K, Fujii-Kuriyama Y, Mizukami Y, etal |title=Primary structure of human pepsinogen gene. |journal=J. Biol. Chem. |volume=258 |issue= 8 |pages= 5306–11 |year= 1983 |pmid= 6300126 |doi=  }}
*{{cite journal | author=Fujinaga M, Chernaia MM, Tarasova NI, ''et al.'' |title=Crystal structure of human pepsin and its complex with pepstatin. |journal=Protein Sci. |volume=4 |issue= 5 |pages= 960-72 |year= 1995 |pmid= 7663352 |doi=  }}
*{{cite journal   |vauthors=Fujinaga M, Chernaia MM, Tarasova NI, etal |title=Crystal structure of human pepsin and its complex with pepstatin. |journal=Protein Sci. |volume=4 |issue= 5 |pages= 960–72 |year= 1995 |pmid= 7663352 |doi=10.1002/pro.5560040516  | pmc=2143119 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal | author=Zwiers A, ten Dam MA, Crusius JB, ''et al.'' |title=The renal handling of pepsinogen A isozymogens in man. |journal=Clin. Nephrol. |volume=41 |issue= 3 |pages= 153-8 |year= 1994 |pmid= 8187358 |doi=  }}
*{{cite journal   |vauthors=Zwiers A, ten Dam MA, Crusius JB, etal |title=The renal handling of pepsinogen A isozymogens in man. |journal=Clin. Nephrol. |volume=41 |issue= 3 |pages= 153–8 |year= 1994 |pmid= 8187358 |doi=  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Plebani M, Basso D, Navaglia F, DiMario F |title=Helicobacter pylori genotypes influence serum pepsinogen C levels. |journal=Helicobacter |volume=2 |issue= 4 |pages= 172-5 |year= 1998 |pmid= 9421118 |doi=  }}
*{{cite journal  | vauthors=Plebani M, Basso D, Navaglia F, DiMario F |title=Helicobacter pylori genotypes influence serum pepsinogen C levels. |journal=Helicobacter |volume=2 |issue= 4 |pages= 172–5 |year= 1998 |pmid= 9421118 |doi=10.1111/j.1523-5378.1997.tb00082.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5222}}
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Latest revision as of 13:37, 7 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pepsin A is a protein that in humans is encoded by the PGA5 gene.[1]


References

  1. ↑ "Entrez Gene: PGA5 pepsinogen 5, group I (pepsinogen A)".

Further reading



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