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{{Infobox_gene}}
{{GNF_Protein_box
'''Remodeling and spacing factor 1''' is a [[protein]] that in humans is encoded by the ''RSF1'' [[gene]].<ref name="pmid11788598">{{cite journal | vauthors = Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y | title = Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription | journal = J Biol Chem | volume = 277 | issue = 12 | pages = 9982–8 |date=Mar 2002 | pmid = 11788598 | pmc =  | doi = 10.1074/jbc.M111354200 }}</ref><ref name="pmid12972596">{{cite journal | vauthors = Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D | title = Functional analysis of the subunits of the chromatin assembly factor RSF | journal = Mol Cell Biol | volume = 23 | issue = 19 | pages = 6759–68 |date=Sep 2003 | pmid = 12972596 | pmc = 193931 | doi =10.1128/MCB.23.19.6759-6768.2003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RSF1 remodeling and spacing factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51773| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Remodeling and spacing factor 1
| HGNCid = 18118
| Symbol = RSF1
| AltSymbols =; HBXAP; RSF-1; XAP8; p325
| OMIM = 608522
| ECnumber = 
| Homologene = 41142
| MGIid = 2682305
| GeneAtlas_image1 = PBB_GE_RSF1_218166_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042393 |text = histone binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0031213 |text = RSF complex}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0016584 |text = nucleosome positioning}} {{GNF_GO|id=GO:0043392 |text = negative regulation of DNA binding}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0050434 |text = positive regulation of viral transcription}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51773
    | Hs_Ensembl = ENSG00000048649
    | Hs_RefseqProtein = NP_057662
    | Hs_RefseqmRNA = NM_016578
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 77054923
    | Hs_GenLoc_end = 77209528
    | Hs_Uniprot = Q96T23
    | Mm_EntrezGene = 233532
    | Mm_Ensembl = ENSMUSG00000035623
    | Mm_RefseqmRNA = XM_620529
    | Mm_RefseqProtein = XP_620529
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 97455114
    | Mm_GenLoc_end = 97561176
    | Mm_Uniprot = 
  }}
}}
'''Remodeling and spacing factor 1''', also known as '''RSF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RSF1 remodeling and spacing factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51773| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RSF1 remodeling and spacing factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51773| accessdate = }}</ref>
| summary_text = HBXAP is involved in [[transcription (biology)|transcription]] repression, transcription coactivation when associated with [[hepatitis B virus]] X protein (HBX), and [[chromatin]] remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RSF1 remodeling and spacing factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51773| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lee TH, Elledge SJ, Butel JS |title=Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. |journal=J. Virol. |volume=69 |issue= 2 |pages= 1107-14 |year= 1995 |pmid= 7815490 |doi=  }}
*{{cite journal  | vauthors=Lee TH, Elledge SJ, Butel JS |title=Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. |journal=J. Virol. |volume=69 |issue= 2 |pages= 1107–14 |year= 1995 |pmid= 7815490 |doi= | pmc=188683 }}
*{{cite journal  | author=LeRoy G, Orphanides G, Lane WS, Reinberg D |title=Requirement of RSF and FACT for transcription of chromatin templates in vitro. |journal=Science |volume=282 |issue= 5395 |pages= 1900-4 |year= 1998 |pmid= 9836642 |doi= }}
*{{cite journal  | vauthors=LeRoy G, Orphanides G, Lane WS, Reinberg D |title=Requirement of RSF and FACT for transcription of chromatin templates in vitro. |journal=Science |volume=282 |issue= 5395 |pages= 1900–4 |year= 1998 |pmid= 9836642 |doi=10.1126/science.282.5395.1900  }}
*{{cite journal  | author=Shamay M, Barak O, Doitsh G, ''et al.'' |title=Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9982-8 |year= 2002 |pmid= 11788598 |doi= 10.1074/jbc.M111354200 }}
*{{cite journal  | vauthors=Shamay M, Barak O, Shaul Y |title=HBXAP, a novel PHD-finger protein, possesses transcription repression activity. |journal=Genomics |volume=79 |issue= 4 |pages= 523–9 |year= 2002 |pmid= 11944984 |doi= 10.1006/geno.2002.6717 }}
*{{cite journal  | author=Shamay M, Barak O, Shaul Y |title=HBXAP, a novel PHD-finger protein, possesses transcription repression activity. |journal=Genomics |volume=79 |issue= 4 |pages= 523-9 |year= 2002 |pmid= 11944984 |doi= 10.1006/geno.2002.6717 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Loyola A, Huang JY, LeRoy G, ''et al.'' |title=Functional analysis of the subunits of the chromatin assembly factor RSF. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6759-68 |year= 2003 |pmid= 12972596 |doi=  }}
*{{cite journal   |vauthors=Obuse C, Yang H, Nozaki N, etal |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Huang JY, Shen BJ, Tsai WH, Lee SC |title=Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB. |journal=Exp. Cell Res. |volume=298 |issue= 1 |pages= 133–43 |year= 2004 |pmid= 15242768 |doi= 10.1016/j.yexcr.2004.04.019 }}
*{{cite journal | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105-20 |year= 2004 |pmid= 15009096 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Huang JY, Shen BJ, Tsai WH, Lee SC |title=Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB. |journal=Exp. Cell Res. |volume=298 |issue= 1 |pages= 133-43 |year= 2004 |pmid= 15242768 |doi= 10.1016/j.yexcr.2004.04.019 }}
*{{cite journal  | vauthors=((Shih IeM)), Sheu JJ, Santillan A|title=Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 39 |pages= 14004–9 |year= 2005 |pmid= 16172393 |doi= 10.1073/pnas.0504195102 | pmc=1236547 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Shih IeM, Sheu JJ, Santillan A, ''et al.'' |title=Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 39 |pages= 14004-9 |year= 2005 |pmid= 16172393 |doi= 10.1073/pnas.0504195102 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 19:11, 19 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.[1][2][3]

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM][3]

References

  1. ↑ Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
  2. ↑ Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
  3. ↑ 3.0 3.1 "Entrez Gene: RSF1 remodeling and spacing factor 1".

Further reading



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