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{{Infobox_gene}}
{{PBB_Controls
'''Lymphatic vessel endothelial hyaluronan receptor 1''' ('''LYVE1'''), also known as '''extracellular link domain containing 1''' ('''XLKD1''') is a [[Link domain]]-containing [[hyaladherin]], a protein capable of binding to [[hyaluronic acid]] (HA), homologous to [[CD44]], the main HA receptor.<ref>{{cite journal|last1=Banerji|first1=Suneale|last2=Ni|first2=Jian|last3=Wang|first3=Shu-Xia|last4=Clasper|first4=Steven|last5=Su|first5=Jeffrey|last6=Tammi|first6=Raija|last7=Jones|first7=Margaret|last8=Jackson|first8=David G.|title=LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan|journal=The Journal of Cell Biology|date=22 February 1999|volume=144|issue=4|pages=789–801|doi=10.1083/jcb.144.4.789|pmid=10037799|pmc=2132933}}</ref> In humans it is encoded by the ''LYVE1'' gene.<ref name="entrez">{{cite web | title = LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens (human) ]| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10894| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
LYVE1 is a type I integral membrane [[glycoprotein]]. It acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.<ref name="entrez"/> LYVE-1 is a cell surface receptor on [[Lymphatic endothelium|lymphatic endothelial cells]] that can be used as a lymphatic endothelial cell marker, allowing for the [[Cell sorting|isolation]] of these cells for experimental purposes. The physiological role for this receptor is still the subject of debate, but evolutionary conservation suggests an important role.
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Extracellular link domain containing 1
| HGNCid = 14687
| Symbol = XLKD1
| AltSymbols =; CRSBP-1; HAR; LYVE-1
| OMIM = 605702
| ECnumber = 
| Homologene = 4868
| MGIid = 2136348
| GeneAtlas_image1 = PBB_GE_XLKD1_219059_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_XLKD1_220037_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005540 |text = hyaluronic acid binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006027 |text = glycosaminoglycan catabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10894
    | Hs_Ensembl = ENSG00000133800
    | Hs_RefseqProtein = NP_006682
    | Hs_RefseqmRNA = NM_006691
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 10535990
    | Hs_GenLoc_end = 10546855
    | Hs_Uniprot = Q9Y5Y7
    | Mm_EntrezGene = 114332
    | Mm_Ensembl = ENSMUSG00000030787
    | Mm_RefseqmRNA = NM_053247
    | Mm_RefseqProtein = NP_444477
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 110641788
    | Mm_GenLoc_end = 110654134
    | Mm_Uniprot = Q8BHC0
  }}
}}
'''Extracellular link domain containing 1''', also known as '''XLKD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: XLKD1 extracellular link domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10894| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.<ref name="entrez">{{cite web | title = Entrez Gene: XLKD1 extracellular link domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10894| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Jackson DG |title=The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. |journal=Trends Cardiovasc. Med. |volume=13 |issue= 1 |pages= 1-7 |year= 2003 |pmid= 12554094 |doi=  }}
*{{cite journal  | author=Jackson DG |title=The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. |journal=Trends Cardiovasc. Med. |volume=13 |issue= 1 |pages= 1–7 |year= 2003 |pmid= 12554094 |doi=10.1016/S1050-1738(02)00189-5 }}
*{{cite journal | author=Banerji S, Ni J, Wang SX, ''et al.'' |title=LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. |journal=J. Cell Biol. |volume=144 |issue= 4 |pages= 789-801 |year= 1999 |pmid= 10037799 |doi=  }}
*{{cite journal   |vauthors=Banerji S, Ni J, Wang SX, etal |title=LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. |journal=J. Cell Biol. |volume=144 |issue= 4 |pages= 789–801 |year= 1999 |pmid= 10037799 |doi=10.1083/jcb.144.4.789  | pmc=2132933 }}
*{{cite journal  | author=Cunnick GH, Jiang WG, Gomez KF, Mansel RE |title=Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 1043-6 |year= 2001 |pmid= 11689016 |doi= 10.1006/bbrc.2001.5869 }}
*{{cite journal  |vauthors=Cunnick GH, Jiang WG, Gomez KF, Mansel RE |title=Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 1043–6 |year= 2001 |pmid= 11689016 |doi= 10.1006/bbrc.2001.5869 }}
*{{cite journal | author=Mouta Carreira C, Nasser SM, di Tomaso E, ''et al.'' |title=LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8079-84 |year= 2001 |pmid= 11719431 |doi=  }}
*{{cite journal   |vauthors=Mouta Carreira C, Nasser SM, di Tomaso E, etal |title=LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8079–84 |year= 2001 |pmid= 11719431 |doi=  }}
*{{cite journal | author=Cursiefen C, Schlötzer-Schrehardt U, Küchle M, ''et al.'' |title=Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. |journal=Invest. Ophthalmol. Vis. Sci. |volume=43 |issue= 7 |pages= 2127-35 |year= 2002 |pmid= 12091407 |doi=  }}
*{{cite journal   |vauthors=Cursiefen C, Schlötzer-Schrehardt U, Küchle M, etal |title=Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. |journal=Invest. Ophthalmol. Vis. Sci. |volume=43 |issue= 7 |pages= 2127–35 |year= 2002 |pmid= 12091407 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Huang SS, Tang FM, Huang YH, ''et al.'' |title=Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43855-69 |year= 2003 |pmid= 12912978 |doi= 10.1074/jbc.M306411200 }}
*{{cite journal   |vauthors=Huang SS, Tang FM, Huang YH, etal |title=Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43855–69 |year= 2003 |pmid= 12912978 |doi= 10.1074/jbc.M306411200 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Nguyen VA, Kutzner H, Fürhapter C, ''et al.'' |title=Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence. |journal=Mod. Pathol. |volume=19 |issue= 2 |pages= 291-8 |year= 2006 |pmid= 16424896 |doi= 10.1038/modpathol.3800537 }}
*{{cite journal   |vauthors=Nguyen VA, Kutzner H, Fürhapter C, etal |title=Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence. |journal=Mod. Pathol. |volume=19 |issue= 2 |pages= 291–8 |year= 2006 |pmid= 16424896 |doi= 10.1038/modpathol.3800537 }}
*{{cite journal | author=Gu B, Alexander JS, Gu Y, ''et al.'' |title=Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta. |journal=Lymphatic research and biology |volume=4 |issue= 1 |pages= 11-7 |year= 2007 |pmid= 16569201 |doi= 10.1089/lrb.2006.4.11 }}
*{{cite journal   |vauthors=Gu B, Alexander JS, Gu Y, etal |title=Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta. |journal=Lymphatic research and biology |volume=4 |issue= 1 |pages= 11–7 |year= 2007 |pmid= 16569201 |doi= 10.1089/lrb.2006.4.11 |pmc=3072054}}
*{{cite journal | author=Llovet JM, Chen Y, Wurmbach E, ''et al.'' |title=A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. |journal=Gastroenterology |volume=131 |issue= 6 |pages= 1758-67 |year= 2007 |pmid= 17087938 |doi= 10.1053/j.gastro.2006.09.014 }}
*{{cite journal   |vauthors=Llovet JM, Chen Y, Wurmbach E, etal |title=A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. |journal=Gastroenterology |volume=131 |issue= 6 |pages= 1758–67 |year= 2007 |pmid= 17087938 |doi= 10.1053/j.gastro.2006.09.014 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-11-stub}}
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[[Category:Glycoproteins]]

Latest revision as of 00:13, 29 July 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor.[1] In humans it is encoded by the LYVE1 gene.[2]

LYVE1 is a type I integral membrane glycoprotein. It acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.[2] LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, allowing for the isolation of these cells for experimental purposes. The physiological role for this receptor is still the subject of debate, but evolutionary conservation suggests an important role.

References

  1. ↑ Banerji, Suneale; Ni, Jian; Wang, Shu-Xia; Clasper, Steven; Su, Jeffrey; Tammi, Raija; Jones, Margaret; Jackson, David G. (22 February 1999). "LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan". The Journal of Cell Biology. 144 (4): 789–801. doi:10.1083/jcb.144.4.789. PMC 2132933. PMID 10037799.
  2. ↑ 2.0 2.1 "LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens (human) ]".

Further reading

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