NELL1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Protein kinase C-binding protein NELL1''' also known as '''NEL-like protein 1''' (NELL1) or '''Nel-related protein 1''' (NRP1) is a [[protein]] that in humans is encoded by the ''NELL1'' [[gene]].<ref name="pmid8975702">{{cite journal | vauthors = Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E | title = Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats | journal = Genomics | volume = 38 | issue = 3 | pages = 273–6 |date=Mar 1997 | pmid = 8975702 | pmc =  | doi =10.1006/geno.1996.0628  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NELL1 NEL-like 1 (chicken)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4745| accessdate = }}</ref><ref name="medicalxpress">{{cite web | title = Study reveals bone-building protein's impact on bone stem cells| url = http://medicalxpress.com/news/2015-06-reveals-bone-building-protein-impact-bone.html| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = NEL-like 1 (chicken)
| HGNCid = 7750
| Symbol = NELL1
| AltSymbols =; IDH3GL; NRP1
| OMIM = 602319
| ECnumber = 
| Homologene = 4486
| MGIid = 2443902
| GeneAtlas_image1 = PBB_GE_NELL1_206089_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016652 |text = oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor}}
| Component =
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4745
    | Hs_Ensembl = ENSG00000165973
    | Hs_RefseqProtein = NP_006148
    | Hs_RefseqmRNA = NM_006157
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 20647693
    | Hs_GenLoc_end = 21553803
    | Hs_Uniprot = Q92832
    | Mm_EntrezGene = 338352
    | Mm_Ensembl = ENSMUSG00000055409
    | Mm_RefseqmRNA = XM_993693
    | Mm_RefseqProtein = NP_001032995
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 49843371
    | Mm_GenLoc_end = 50731308
    | Mm_Uniprot = 
  }}
}}
'''NEL-like 1 (chicken)''', also known as '''NELL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NELL1 NEL-like 1 (chicken)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4745| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[cytoplasmic]] protein that contains [[epidermal growth factor]] (EGF) -like repeats. The encoded [[heteromer|heterotrimeric]] protein may be involved in cell growth regulation and [[cell differentiation|differentiation]]. A similar protein in rodents is involved in [[craniosynostosis]]. An alternative [[splice variant]] has been described but its full-length sequence has not been determined.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of [[stem cell]]s.<ref name="medicalxpress"/>
| summary_text = This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NELL1 NEL-like 1 (chicken)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4745| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Auffray C, Behar G, Bois F, etal |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi=  }}
| citations =
*{{cite journal   |vauthors=Ting K, Vastardis H, Mulliken JB, etal |title=Human NELL-1 expressed in unilateral coronal synostosis. |journal=J. Bone Miner. Res. |volume=14 |issue= 1 |pages= 80–9 |year= 1999 |pmid= 9893069 |doi=10.1359/jbmr.1999.14.1.80 }}
*{{cite journal | author=Auffray C, Behar G, Bois F, ''et al.'' |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263-72 |year= 1995 |pmid= 7757816 |doi=  }}
*{{cite journal  | vauthors=Luce MJ, Burrows PD |title=The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. |journal=Gene |volume=231 |issue= 1–2 |pages= 121–6 |year= 1999 |pmid= 10231576 |doi=10.1016/S0378-1119(99)00093-1 }}
*{{cite journal | author=Watanabe TK, Katagiri T, Suzuki M, ''et al.'' |title=Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. |journal=Genomics |volume=38 |issue= 3 |pages= 273-6 |year= 1997 |pmid= 8975702 |doi=  }}
*{{cite journal   |vauthors=Kuroda S, Oyasu M, Kawakami M, etal |title=Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2 |journal=Biochem. Biophys. Res. Commun. |volume=265 |issue= 1 |pages= 79–86 |year= 1999 |pmid= 10548494 |doi= 10.1006/bbrc.1999.1638 }}
*{{cite journal  | author=Ting K, Vastardis H, Mulliken JB, ''et al.'' |title=Human NELL-1 expressed in unilateral coronal synostosis. |journal=J. Bone Miner. Res. |volume=14 |issue= 1 |pages= 80-9 |year= 1999 |pmid= 9893069 |doi=  }}
*{{cite journal   |vauthors=Maeda K, Matsuhashi S, Tabuchi K, etal |title=Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors |journal=Neurol. Med. Chir. (Tokyo) |volume=41 |issue= 12 |pages= 582–8; discussion 589 |year= 2002 |pmid= 11803583 |doi=10.2176/nmc.41.582 }}
*{{cite journal  | author=Luce MJ, Burrows PD |title=The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. |journal=Gene |volume=231 |issue= 1-2 |pages= 121-6 |year= 1999 |pmid= 10231576 |doi=  }}
*{{cite journal   |vauthors=Zhang X, Kuroda S, Carpenter D, etal |title=Craniosynostosis in transgenic mice overexpressing Nell-1 |journal=J. Clin. Invest. |volume=110 |issue= 6 |pages= 861–70 |year= 2002 |pmid= 12235118 |doi=10.1172/JCI15375  | pmc=151127 }}
*{{cite journal | author=Kuroda S, Oyasu M, Kawakami M, ''et al.'' |title=Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. |journal=Biochem. Biophys. Res. Commun. |volume=265 |issue= 1 |pages= 79-86 |year= 1999 |pmid= 10548494 |doi= 10.1006/bbrc.1999.1638 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Maeda K, Matsuhashi S, Tabuchi K, ''et al.'' |title=Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors. |journal=Neurol. Med. Chir. (Tokyo) |volume=41 |issue= 12 |pages= 582-8; discussion 589 |year= 2002 |pmid= 11803583 |doi=  }}
*{{cite journal   |vauthors=Okamoto K, Matsuzaka Y, Yoshikawa Y, etal |title=Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphisms |journal=Gene |volume=323 |issue=  |pages= 141–8 |year= 2004 |pmid= 14659887 |doi=10.1016/j.gene.2003.09.014 }}
*{{cite journal | author=Zhang X, Kuroda S, Carpenter D, ''et al.'' |title=Craniosynostosis in transgenic mice overexpressing Nell-1. |journal=J. Clin. Invest. |volume=110 |issue= 6 |pages= 861-70 |year= 2002 |pmid= 12235118 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Tsutsumi S, Kamata N, Vokes TJ, etal |title=The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD) |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255–61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 | pmc=1182089 }}
*{{cite journal | author=Okamoto K, Matsuzaka Y, Yoshikawa Y, ''et al.'' |title=Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphisms. |journal=Gene |volume=323 |issue=  |pages= 141-8 |year= 2004 |pmid= 14659887 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Tsutsumi S, Kamata N, Vokes TJ, ''et al.'' |title=The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255-61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 }}
*{{cite journal   |vauthors=Truong T, Zhang X, Pathmanathan D, etal |title=Craniosynostosis-associated gene nell-1 is regulated by runx2 |journal=J. Bone Miner. Res. |volume=22 |issue= 1 |pages= 7–18 |year= 2007 |pmid= 17042739 |doi= 10.1359/jbmr.061012 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Jin Z, Mori Y, Yang J, etal |title=Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma |journal=Oncogene |volume=26 |issue= 43 |pages= 6332–40 |year= 2007 |pmid= 17452981 |doi= 10.1038/sj.onc.1210461 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Truong T, Zhang X, Pathmanathan D, ''et al.'' |title=Craniosynostosis-associated gene nell-1 is regulated by runx2. |journal=J. Bone Miner. Res. |volume=22 |issue= 1 |pages= 7-18 |year= 2007 |pmid= 17042739 |doi= 10.1359/jbmr.061012 }}
*{{cite journal | author=Jin Z, Mori Y, Yang J, ''et al.'' |title=Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. |journal=Oncogene |volume=26 |issue= 43 |pages= 6332-40 |year= 2007 |pmid= 17452981 |doi= 10.1038/sj.onc.1210461 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}
 
 
{{gene-11-stub}}

Latest revision as of 03:54, 6 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.[1][2][3]

Function

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.[2]

Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.[3]

References

  1. ↑ Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E (Mar 1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics. 38 (3): 273–6. doi:10.1006/geno.1996.0628. PMID 8975702.
  2. ↑ 2.0 2.1 "Entrez Gene: NELL1 NEL-like 1 (chicken)".
  3. ↑ 3.0 3.1 "Study reveals bone-building protein's impact on bone stem cells".

Further reading


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