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{{Infobox_gene}}
{{PBB_Controls
'''Leucine-rich repeats and death domain containing''', also known as '''LRDD''' or p53-induced protein with a death domain (PIDD), is a [[protein]] which in humans is encoded by the ''LRDD'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRDD leucine-rich repeats and death domain containing| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55367| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_LRDD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2of5.
| PDB = {{PDB2|2of5}}
| Name = Leucine-rich repeats and death domain containing
| HGNCid = 16491
| Symbol = LRDD
| AltSymbols =; DKFZp434D229; MGC16925; PIDD
| OMIM = 605247
| ECnumber = 
| Homologene = 11220
| MGIid = 1889507
| GeneAtlas_image1 = PBB_GE_LRDD_219019_at_tn.png
| GeneAtlas_image2 = PBB_GE_LRDD_221640_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55367
    | Hs_Ensembl = ENSG00000177595
    | Hs_RefseqProtein = NP_060964
    | Hs_RefseqmRNA = NM_018494
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 789185
    | Hs_GenLoc_end = 794388
    | Hs_Uniprot = Q9HB75
    | Mm_EntrezGene = 57913
    | Mm_Ensembl = ENSMUSG00000025507
    | Mm_RefseqmRNA = NM_022654
    | Mm_RefseqProtein = NP_073145
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 141289437
    | Mm_GenLoc_end = 141295312
    | Mm_Uniprot = Q9ERV7
  }}
}}
'''Leucine-rich repeats and death domain containing''', also known as '''LRDD''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRDD leucine-rich repeats and death domain containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55367| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene contains a [[leucine-rich repeat]] and a [[death domain]]. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain ([[FADD]]) and [[mitogen-activated protein kinase|MAP-kinase]] activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor [[p53]] and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent [[apoptosis]]. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez" /> Besides its pro-apoptotic function it may also be involved in [[DNA repair]] as part of a protein complex formed together with the catalytic subunit of DNA-PK ([[DNA-PKcs]])and [[caspase 2]].
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: LRDD leucine-rich repeats and death domain containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55367| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Telliez JB, Bean KM, Lin LL |title=LRDD, a novel leucine rich repeat and death domain containing protein. |journal=Biochim. Biophys. Acta |volume=1478 |issue= 2 |pages= 280-8 |year= 2000 |pmid= 10825539 |doi=  }}
*{{cite journal  |vauthors=Telliez JB, Bean KM, Lin LL |title=LRDD, a novel leucine rich repeat and death domain containing protein |journal=Biochim. Biophys. Acta |volume=1478 |issue= 2 |pages= 280–8 |year= 2000 |pmid= 10825539 |doi=10.1016/S0167-4838(00)00029-7 }}
*{{cite journal  | author=Lin Y, Ma W, Benchimol S |title=Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. |journal=Nat. Genet. |volume=26 |issue= 1 |pages= 122-7 |year= 2000 |pmid= 10973264 |doi= 10.1038/79102 }}
*{{cite journal  |vauthors=Lin Y, Ma W, Benchimol S |title=Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis |journal=Nat. Genet. |volume=26 |issue= 1 |pages= 122–7 |year= 2000 |pmid= 10973264 |doi= 10.1038/79102 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Tinel A, Tschopp J |title=The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. |journal=Science |volume=304 |issue= 5672 |pages= 843-6 |year= 2004 |pmid= 15073321 |doi= 10.1126/science.1095432 }}
*{{cite journal  |vauthors=Tinel A, Tschopp J |title=The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress |journal=Science |volume=304 |issue= 5672 |pages= 843–6 |year= 2004 |pmid= 15073321 |doi= 10.1126/science.1095432 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Janssens S, Tinel A, Lippens S, Tschopp J |title=PIDD mediates NF-kappaB activation in response to DNA damage. |journal=Cell |volume=123 |issue= 6 |pages= 1079-92 |year= 2006 |pmid= 16360037 |doi= 10.1016/j.cell.2005.09.036 }}
*{{cite journal  |vauthors=Janssens S, Tinel A, Lippens S, Tschopp J |title=PIDD mediates NF-kappaB activation in response to DNA damage |journal=Cell |volume=123 |issue= 6 |pages= 1079–92 |year= 2006 |pmid= 16360037 |doi= 10.1016/j.cell.2005.09.036 }}
*{{cite journal  | author=Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B |title=Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. |journal=Oncogene |volume=25 |issue= 41 |pages= 5683-92 |year= 2006 |pmid= 16652156 |doi= 10.1038/sj.onc.1209569 }}
*{{cite journal  |vauthors=Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B |title=Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage |journal=Oncogene |volume=25 |issue= 41 |pages= 5683–92 |year= 2006 |pmid= 16652156 |doi= 10.1038/sj.onc.1209569 }}
*{{cite journal  | author=Pick R, Badura S, Bösser S, Zörnig M |title=Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 4 |pages= 1329-38 |year= 2006 |pmid= 16982033 |doi= 10.1016/j.bbrc.2006.08.176 }}
*{{cite journal  |vauthors=Pick R, Badura S, Bösser S, Zörnig M |title=Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 4 |pages= 1329–38 |year= 2006 |pmid= 16982033 |doi= 10.1016/j.bbrc.2006.08.176 }}
*{{cite journal | author=Tinel A, Janssens S, Lippens S, ''et al.'' |title=Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. |journal=EMBO J. |volume=26 |issue= 1 |pages= 197-208 |year= 2007 |pmid= 17159900 |doi= 10.1038/sj.emboj.7601473 }}
*{{cite journal   |vauthors=Tinel A, Janssens S, Lippens S, etal |title=Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway |journal=EMBO J. |volume=26 |issue= 1 |pages= 197–208 |year= 2007 |pmid= 17159900 |doi= 10.1038/sj.emboj.7601473 | pmc=1782377 }}
*{{cite journal  | author=Park HH, Wu H |title=Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=63 |issue= Pt 3 |pages= 229-32 |year= 2007 |pmid= 17329820 |doi= 10.1107/S1744309107007889 }}
*{{cite journal  |vauthors=Park HH, Wu H |title=Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD |journal=Acta Crystallographica Section F |volume=63 |issue= Pt 3 |pages= 229–32 |year= 2007 |pmid= 17329820 |doi= 10.1107/S1744309107007889 | pmc=2330181 }}
*{{cite journal | author=Bradley G, Tremblay S, Irish J, ''et al.'' |title=The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma. |journal=Br. J. Cancer |volume=96 |issue= 9 |pages= 1425-32 |year= 2007 |pmid= 17437012 |doi= 10.1038/sj.bjc.6603745 }}
*{{cite journal   |vauthors=Bradley G, Tremblay S, Irish J, etal |title=The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma |journal=Br. J. Cancer |volume=96 |issue= 9 |pages= 1425–32 |year= 2007 |pmid= 17437012 |doi= 10.1038/sj.bjc.6603745 | pmc=2360189 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=55367}}
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{{gene-11-stub}}
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Latest revision as of 15:29, 8 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.[1]

Function

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[1] Besides its pro-apoptotic function it may also be involved in DNA repair as part of a protein complex formed together with the catalytic subunit of DNA-PK (DNA-PKcs)and caspase 2.

References

  1. ↑ 1.0 1.1 "Entrez Gene: LRDD leucine-rich repeats and death domain containing".

Further reading



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