EI24: Difference between revisions
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'''Etoposide-induced protein 2.4 homolog''' is a [[protein]] that in humans is encoded by the ''EI24'' [[gene]].<ref name="pmid10594026">{{cite journal | vauthors = Gu Z, Flemington C, Chittenden T, Zambetti GP | title = ei24, a p53 response gene involved in growth suppression and apoptosis | journal = Mol Cell Biol | volume = 20 | issue = 1 | pages = 233–41 |date=Jan 2000 | pmid = 10594026 | pmc = 85079 | doi =10.1128/MCB.20.1.233-241.2000 }}</ref><ref name="pmid9305847">{{cite journal | vauthors = Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B | title = A model for p53-induced apoptosis | journal = Nature | volume = 389 | issue = 6648 | pages = 300–5 |date=Sep 1997 | pmid = 9305847 | pmc = | doi = 10.1038/38525 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EI24 etoposide induced 2.4 mRNA| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9538| accessdate = }}</ref> | '''Etoposide-induced protein 2.4 homolog''' is a [[protein]] that in humans is encoded by the ''EI24'' [[gene]].<ref name="pmid10594026">{{cite journal | vauthors = Gu Z, Flemington C, Chittenden T, Zambetti GP | title = ei24, a p53 response gene involved in growth suppression and apoptosis | journal = Mol Cell Biol | volume = 20 | issue = 1 | pages = 233–41 |date=Jan 2000 | pmid = 10594026 | pmc = 85079 | doi =10.1128/MCB.20.1.233-241.2000 }}</ref><ref name="pmid9305847">{{cite journal | vauthors = Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B | title = A model for p53-induced apoptosis | journal = Nature | volume = 389 | issue = 6648 | pages = 300–5 |date=Sep 1997 | pmid = 9305847 | pmc = | doi = 10.1038/38525 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EI24 etoposide induced 2.4 mRNA| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9538| accessdate = }}</ref> | ||
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| summary_text = This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez" /> | | summary_text = This gene has higher [[gene expression|expression]] in [[p53]]-expressing cells than in control cells and is an immediate-early induction target of p53-mediated [[apoptosis]]. The protein encoded by this gene contains six putative [[transmembrane domains]] and may suppress [[cell growth]] by inducing apoptotic cell death through the [[caspase 9]] and [[mitochondrial]] pathways. This gene is located on [[chromosome 11|human chromosome 11q24]], a region frequently altered in [[cancers]]. Alternative splicing results in two [[transcript variants]] encoding different [[isoforms]].<ref name="entrez" /> | ||
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Latest revision as of 17:00, 21 February 2018
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Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.[1][2][3]
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.[3]
References
- ↑ Gu Z, Flemington C, Chittenden T, Zambetti GP (Jan 2000). "ei24, a p53 response gene involved in growth suppression and apoptosis". Mol Cell Biol. 20 (1): 233–41. doi:10.1128/MCB.20.1.233-241.2000. PMC 85079. PMID 10594026.
- ↑ Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.
- ↑ 3.0 3.1 "Entrez Gene: EI24 etoposide induced 2.4 mRNA".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Gu Z, Gilbert DJ, Valentine VA, et al. (2000). "The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9". Cytogenet. Cell Genet. 89 (3–4): 230–3. doi:10.1159/000015620. PMID 10965130.
- Burns TF, Bernhard EJ, El-Deiry WS (2001). "Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo". Oncogene. 20 (34): 4601–12. doi:10.1038/sj.onc.1204484. PMID 11498783.
- Gentile M, Ahnström M, Schön F, Wingren S (2002). "Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis". Oncogene. 20 (53): 7753–60. doi:10.1038/sj.onc.1204993. PMID 11753653.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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