HEPN1: Difference between revisions

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{{cite web
| title = Entrez Gene: Hepatocellular carcinoma, down-regulated 1
| title = Entrez Gene: Hepatocellular carcinoma, down-regulated 1
| url = http://www.ncbi.nlm.nih.gov/gene/641654
| url = https://www.ncbi.nlm.nih.gov/gene/641654
| accessdate = 2017-09-12
| accessdate = 2017-09-12
}}</ref>
}}</ref>

Latest revision as of 21:11, 19 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. [1]

Function

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354).

References

  1. "Entrez Gene: Hepatocellular carcinoma, down-regulated 1". Retrieved 2017-09-12.

Further reading

  • Peng H, Fan J, Wu J, Lang J, Wang J, Liu H, Zhao S, Liao J (2013). "Silencing of HEPN1 is responsible for the aggressive biological behavior of pituitary somatotroph adenomas". Cell. Physiol. Biochem. 31 (2–3): 379–88. doi:10.1159/000343375. PMID 23548416.
  • Kim HS, Jung G (2014). "Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor". FEBS Lett. 588 (23): 4413–21. doi:10.1016/j.febslet.2014.10.011. PMID 25448679.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.