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{{Infobox_gene}}
{{PBB_Controls
'''Myosin-binding protein C, slow-type''' is a [[protein]] that in humans is encoded by the ''MYBPC1'' [[gene]].<ref name="pmid8375400">{{cite journal |vauthors=Weber FE, Vaughan KT, Reinach FC, Fischman DA | title = Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment | journal = Eur J Biochem | volume = 216 | issue = 2 | pages = 661–9 |date=Oct 1993 | pmid = 8375400 | pmc =  | doi =10.1111/j.1432-1033.1993.tb18186.x }}</ref><ref name="pmid16918501">{{cite journal |vauthors=Flashman E, Watkins H, Redwood C | title = Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod | journal = Biochem J | volume = 401 | issue = 1 | pages = 97–102 |date=Dec 2006 | pmid = 16918501 | pmc = 1698665 | doi = 10.1042/BJ20060500 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYBPC1 myosin binding protein C, slow type| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4604| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MYBPC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x44.
| PDB = {{PDB2|1x44}}, {{PDB2|2dav}}
| Name = Myosin binding protein C, slow type
| HGNCid = 7549
| Symbol = MYBPC1
| AltSymbols =; MYBPCC; MYBPCS; slow-type
| OMIM = 160794
| ECnumber =
| Homologene = 1846
| MGIid = 1924741
  | GeneAtlas_image1 = PBB_GE_MYBPC1_214087_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005863 |text = striated muscle thick filament}}
| Process = {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4604
    | Hs_Ensembl = ENSG00000196091
    | Hs_RefseqProtein = NP_002456
    | Hs_RefseqmRNA = NM_002465
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 100512878
    | Hs_GenLoc_end = 100603789
    | Hs_Uniprot = Q00872
    | Mm_EntrezGene = 109272
    | Mm_Ensembl = ENSMUSG00000020061
    | Mm_RefseqmRNA = NM_175418
    | Mm_RefseqProtein = NP_780627
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 87952755
    | Mm_GenLoc_end = 88015495
    | Mm_Uniprot = 
  }}
}}
'''Myosin binding protein C, slow type''', also known as '''MYBPC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYBPC1 myosin binding protein C, slow type| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4604| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Fürst DO, Vinkemeier U, Weber K |title=Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA. |journal=J. Cell. Sci. |volume=102 ( Pt 4) |issue=  |pages= 769-78 |year= 1992 |pmid= 1429890 |doi=  }}
*{{cite journal  |vauthors=Fürst DO, Vinkemeier U, Weber K |title=Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA. |journal=J. Cell Sci. |volume=102 |issue=  4|pages= 769–78 |year= 1992 |pmid= 1429890 |doi=  }}
*{{cite journal  | author=Johnston LH, Barker DG, Nurse P |title=Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17. |journal=Gene |volume=41 |issue= 2-3 |pages= 321-5 |year= 1986 |pmid= 3011605 |doi=  }}
*{{cite journal  |vauthors=Johnston LH, Barker DG, Nurse P |title=Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17. |journal=Gene |volume=41 |issue= 2–3 |pages= 321–5 |year= 1986 |pmid= 3011605 |doi=10.1016/0378-1119(86)90114-9 }}
*{{cite journal  | author=Auffray C, Behar G, Bois F, ''et al.'' |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263-72 |year= 1995 |pmid= 7757816 |doi=  }}
*{{cite journal  | author=Auffray C |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi=  |name-list-format=vanc| author2=Behar G | author3=Bois F  | display-authors=3  | last4=Bouchier  | first4=C | last5=Da Silva  | first5=| last6=Devignes  | first6=MD  | last7=Duprat  | first7=| last8=Houlgatte  | first8=R  | last9=Jumeau  | first9=MN }}
*{{cite journal | author=Weber FE, Vaughan KT, Reinach FC, Fischman DA |title=Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. |journal=Eur. J. Biochem. |volume=216 |issue= 2 |pages= 661-9 |year= 1993 |pmid= 8375400 |doi=  }}
*{{cite journal  | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |name-list-format=vanc| author2=Lennon G  | author3=Becker M  | display-authors=3  | last4=Bonaldo  | first4=M F  | last5=Chiapelli  | first5=B  | last6=Chissoe  | first6=| last7=Dietrich  | first7=| last8=Dubuque  | first8=T | last9=Favello  | first9=A  }}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi= }}
*{{cite journal  |vauthors=Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA |title=Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20866–72 |year= 1997 |pmid= 9252413 |doi=10.1074/jbc.272.33.20866 }}
*{{cite journal | author=Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA |title=Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20866-72 |year= 1997 |pmid= 9252413 |doi}}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072  |name-list-format=vanc| author2=Weil B  | author3=Wellenreuther R  | display-authors=3  | last4=Gassenhuber  | first4=J | last5=Glassl  | first5=| last6=Ansorge  | first6=| last7=Böcher  | first7=| last8=Blöcker | first8=H  | last9=Bauersachs  | first9=S }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732  |name-list-format=vanc| author2=Wellenreuther R  | author3=Poustka A | display-authors=3  | last4=Pepperkok  | first4=| last5=Wiemann  | first5=S }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  |vauthors=Welikson RE, Fischman DA |title=The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells |journal=J. Cell Sci. |volume=115 |issue= Pt 17 |pages= 3517–26 |year= 2003 |pmid= 12154082 |doi= }}
*{{cite journal | author=Welikson RE, Fischman DA |title=The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells. |journal=J. Cell. Sci. |volume=115 |issue= Pt 17 |pages= 3517-26 |year= 2003 |pmid= 12154082 |doi}}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=| last4=Derge  | first4=JG  | last5=Klausner  | first5=RD | last6=Collins  | first6=FS  | last7=Wagner  | first7=| last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Konno T |title=A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients |journal=J. Am. Coll. Cardiol. |volume=41 |issue= 5 |pages= 781–6 |year= 2003 |pmid= 12628722 |doi=10.1016/S0735-1097(02)02957-1 |name-list-format=vanc| author2=Shimizu M  | author3=Ino H  | display-authors=3  | last4=Matsuyama  | first4=Toru  | last5=Yamaguchi  | first5=Masato  | last6=Terai  | first6=Hidenobu  | last7=Hayashi  | first7=Kenshi  | last8=Mabuchi  | first8=Tomohito  | last9=Kiyama  | first9=Masaru  }}
*{{cite journal | author=Konno T, Shimizu M, Ino H, ''et al.'' |title=A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients. |journal=J. Am. Coll. Cardiol. |volume=41 |issue= 5 |pages= 781-6 |year= 2003 |pmid= 12628722 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Beatham J |title=Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres |journal=Hum. Mol. Genet. |volume=13 |issue= 22 |pages= 2863–74 |year= 2006 |pmid= 15385448 |doi= 10.1093/hmg/ddh308  |name-list-format=vanc| author2=Romero R  | author3=Townsend SK  | display-authors=3  | last4=Hacker  | first4=T  | last5=Van Der Ven  | first5=PF  | last6=Blanco  | first6=G }}
*{{cite journal  | author=Beatham J, Romero R, Townsend SK, ''et al.'' |title=Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. |journal=Hum. Mol. Genet. |volume=13 |issue= 22 |pages= 2863-74 |year= 2006 |pmid= 15385448 |doi= 10.1093/hmg/ddh308 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  |vauthors=Dhoot GK, Perry SV |title=Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart |journal=J. Muscle Res. Cell. Motil. |volume=26 |issue= 2–3 |pages= 143–8 |year= 2006 |pmid= 16003462 |doi= 10.1007/s10974-005-3089-1 }}
*{{cite journal | author=Dhoot GK, Perry SV |title=Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart. |journal=J. Muscle Res. Cell. Motil. |volume=26 |issue= 2-3 |pages= 143-8 |year= 2006 |pmid= 16003462 |doi= 10.1007/s10974-005-3089-1 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=McGrath MJ |title=Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 7666–83 |year= 2006 |pmid= 16407297 |doi= 10.1074/jbc.M512552200  |name-list-format=vanc| author2=Cottle DL  | author3=Nguyen MA  | display-authors=3  | last4=Dyson  | first4=JM  | last5=Coghill  | first5=ID  | last6=Robinson  | first6=PA  | last7=Holdsworth  | first7=M  | last8=Cowling  | first8=BS  | last9=Hardeman  | first9=EC }}
*{{cite journal | author=McGrath MJ, Cottle DL, Nguyen MA, ''et al.'' |title=Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 7666-83 |year= 2006 |pmid= 16407297 |doi= 10.1074/jbc.M512552200 }}
*{{cite journal  | author=Flashman E, Watkins H, Redwood C |title=Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod. |journal=Biochem. J. |volume=401 |issue= 1 |pages= 97-102 |year= 2007 |pmid= 16918501 |doi= 10.1042/BJ20060500 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4604}}
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| update_citations = yes
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Latest revision as of 13:40, 7 March 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.[1][2][3]


References

  1. Weber FE, Vaughan KT, Reinach FC, Fischman DA (Oct 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". Eur J Biochem. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.
  2. Flashman E, Watkins H, Redwood C (Dec 2006). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMC 1698665. PMID 16918501.
  3. "Entrez Gene: MYBPC1 myosin binding protein C, slow type".

Further reading