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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Death domain-containing protein CRADD''' is a [[protein]] that in humans is encoded by the ''CRADD'' [[gene]].<ref name="pmid8985253">{{cite journal | vauthors = Duan H, Dixit VM | title = RAIDD is a new 'death' adaptor molecule | journal = Nature | volume = 385 | issue = 6611 | pages = 86–9  | date = January 1997 | pmid = 8985253 | pmc =  | doi = 10.1038/385086a0 }}</ref><ref name="pmid9044836">{{cite journal | vauthors = Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES | title = CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP | journal = Cancer Res. | volume = 57 | issue = 4 | pages = 615–9  | date = March 1997 | pmid = 9044836 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8738| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CRADD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2o71.
| PDB = {{PDB2|2o71}}, {{PDB2|2of5}}, {{PDB2|3crd}}
| Name = CASP2 and RIPK1 domain containing adaptor with death domain
| HGNCid = 2340
| Symbol = CRADD
| AltSymbols =; MGC9163; RAIDD
| OMIM = 603454
| ECnumber = 
| Homologene = 2821
| MGIid = 1336168
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030693 |text = caspase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8738
    | Hs_Ensembl = ENSG00000169372
    | Hs_RefseqProtein = NP_003796
    | Hs_RefseqmRNA = NM_003805
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 92595282
    | Hs_GenLoc_end = 92768658
    | Hs_Uniprot = P78560
    | Mm_EntrezGene = 12905
    | Mm_Ensembl = ENSMUSG00000045867
    | Mm_RefseqmRNA = NM_009950
    | Mm_RefseqProtein = NP_034080
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 94604434
    | Mm_GenLoc_end = 94753785
    | Mm_Uniprot = Q549T4
  }}
}}
'''CASP2 and RIPK1 domain containing adaptor with death domain''', also known as '''CRADD''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8738| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.<ref name="entrez">{{cite web | title = Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8738| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CRADD has been shown to [[Protein-protein interaction|interact]] with [[RIPK1]]<ref name=pmid8985253 /><ref name=pmid9044836 /> and [[Caspase 2]].<ref name=pmid8985253/><ref name=pmid15073321>{{cite journal | vauthors = Tinel A, Tschopp J | title = The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress | journal = Science | volume = 304 | issue = 5672 | pages = 843–6  | date = May 2004 | pmid = 15073321 | doi = 10.1126/science.1095432 }}</ref><ref name=pmid11156409>{{cite journal | vauthors = Droin N, Beauchemin M, Solary E, Bertrand R | title = Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade | journal = Cancer Res. | volume = 60 | issue = 24 | pages = 7039–47  | date = December 2000 | pmid = 11156409 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CRADD}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lennon G, Auffray C, Polymeropoulos M, Soares MB | title = The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression | journal = Genomics | volume = 33 | issue = 1 | pages = 151–2 | year = 1996 | pmid = 8617505 | doi = 10.1006/geno.1996.0177 }}
| citations =
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
*{{cite journal | author=Lennon G, Auffray C, Polymeropoulos M, Soares MB |title=The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. |journal=Genomics |volume=33 |issue= 1 |pages= 151-2 |year= 1996 |pmid= 8617505 |doi= 10.1006/geno.1996.0177 }}
* {{cite journal | vauthors = Chou JJ, Matsuo H, Duan H, Wagner G | title = Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment | journal = Cell | volume = 94 | issue = 2 | pages = 171–80 | year = 1998 | pmid = 9695946 | doi = 10.1016/S0092-8674(00)81417-8 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal | vauthors = Horvat S, Medrano JF | title = A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region | journal = Genomics | volume = 54 | issue = 1 | pages = 159–64 | year = 1998 | pmid = 9806843 | doi = 10.1006/geno.1998.5540 }}
*{{cite journal  | author=Duan H, Dixit VM |title=RAIDD is a new 'death' adaptor molecule. |journal=Nature |volume=385 |issue= 6611 |pages= 86-9 |year= 1997 |pmid= 8985253 |doi= 10.1038/385086a0 }}
* {{cite journal | vauthors = Shearwin-Whyatt LM, Harvey NL, Kumar S | title = Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD | journal = Cell Death Differ. | volume = 7 | issue = 2 | pages = 155–65 | year = 2000 | pmid = 10713730 | doi = 10.1038/sj.cdd.4400632 }}
*{{cite journal  | author=Ahmad M, Srinivasula SM, Wang L, ''et al.'' |title=CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. |journal=Cancer Res. |volume=57 |issue= 4 |pages= 615-9 |year= 1997 |pmid= 9044836 |doi=  }}
* {{cite journal | vauthors = Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L | title = Activation of the NF-kappaB pathway by caspase 8 and its homologs | journal = Oncogene | volume = 19 | issue = 39 | pages = 4451–60 | year = 2000 | pmid = 11002417 | doi = 10.1038/sj.onc.1203812 }}
*{{cite journal | author=Chou JJ, Matsuo H, Duan H, Wagner G |title=Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. |journal=Cell |volume=94 |issue= 2 |pages= 171-80 |year= 1998 |pmid= 9695946 |doi= }}
* {{cite journal | vauthors = Droin N, Beauchemin M, Solary E, Bertrand R | title = Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade | journal = Cancer Res. | volume = 60 | issue = 24 | pages = 7039–47 | year = 2000 | pmid = 11156409 | doi =  }}
*{{cite journal | author=Horvat S, Medrano JF |title=A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. |journal=Genomics |volume=54 |issue= 1 |pages= 159-64 |year= 1999 |pmid= 9806843 |doi= 10.1006/geno.1998.5540 }}
* {{cite journal | vauthors = Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES | title = Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 13430–7 | year = 2002 | pmid = 11832478 | doi = 10.1074/jbc.M108029200 }}
*{{cite journal | author=Shearwin-Whyatt LM, Harvey NL, Kumar S |title=Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. |journal=Cell Death Differ. |volume=7 |issue= 2 |pages= 155-65 |year= 2000 |pmid= 10713730 |doi= 10.1038/sj.cdd.4400632 }}
* {{cite journal | vauthors = Tinel A, Tschopp J | title = The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress | journal = Science | volume = 304 | issue = 5672 | pages = 843–6 | year = 2004 | pmid = 15073321 | doi = 10.1126/science.1095432 }}
*{{cite journal | author=Chaudhary PM, Eby MT, Jasmin A, ''et al.'' |title=Activation of the NF-kappaB pathway by caspase 8 and its homologs. |journal=Oncogene |volume=19 |issue= 39 |pages= 4451-60 |year= 2000 |pmid= 11002417 |doi= 10.1038/sj.onc.1203812 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Droin N, Beauchemin M, Solary E, Bertrand R |title=Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. |journal=Cancer Res. |volume=60 |issue= 24 |pages= 7039-47 |year= 2001 |pmid= 11156409 |doi=  }}
* {{cite journal | vauthors = Park HH, Wu H | title = Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly | journal = J. Mol. Biol. | volume = 357 | issue = 2 | pages = 358–64 | year = 2006 | pmid = 16434054 | pmc = 2902980 | doi = 10.1016/j.jmb.2005.12.082 }}
*{{cite journal | author=Guo Y, Srinivasula SM, Druilhe A, ''et al.'' |title=Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13430-7 |year= 2002 |pmid= 11832478 |doi= 10.1074/jbc.M108029200 }}
* {{cite journal | vauthors = Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B | title = Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage | journal = Oncogene | volume = 25 | issue = 41 | pages = 5683–92 | year = 2006 | pmid = 16652156 | doi = 10.1038/sj.onc.1209569 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Park HH, Wu H | title = Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD | journal = Acta Crystallographica Section F | volume = 63 | issue = Pt 3 | pages = 229–32 | year = 2007 | pmid = 17329820 | pmc = 2330181 | doi = 10.1107/S1744309107007889 }}
*{{cite journal  | author=Tinel A, Tschopp J |title=The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. |journal=Science |volume=304 |issue= 5672 |pages= 843-6 |year= 2004 |pmid= 15073321 |doi= 10.1126/science.1095432 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Park HH, Wu H |title=Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. |journal=J. Mol. Biol. |volume=357 |issue= 2 |pages= 358-64 |year= 2006 |pmid= 16434054 |doi= 10.1016/j.jmb.2005.12.082 }}
*{{cite journal | author=Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B |title=Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. |journal=Oncogene |volume=25 |issue= 41 |pages= 5683-92 |year= 2006 |pmid= 16652156 |doi= 10.1038/sj.onc.1209569 }}
*{{cite journal | author=Park HH, Wu H |title=Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=63 |issue= Pt 3 |pages= 229-32 |year= 2007 |pmid= 17329820 |doi= 10.1107/S1744309107007889 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8738}}
{{WikiDoc Sources}}
 
 
{{gene-12-stub}}

Latest revision as of 15:31, 8 October 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.[1][2][3]

Function

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.[3]

Interactions

CRADD has been shown to interact with RIPK1[1][2] and Caspase 2.[1][4][5]

References

  1. ↑ 1.0 1.1 1.2 Duan H, Dixit VM (January 1997). "RAIDD is a new 'death' adaptor molecule". Nature. 385 (6611): 86–9. doi:10.1038/385086a0. PMID 8985253.
  2. ↑ 2.0 2.1 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES (March 1997). "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP". Cancer Res. 57 (4): 615–9. PMID 9044836.
  3. ↑ 3.0 3.1 "Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain".
  4. ↑ Tinel A, Tschopp J (May 2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science. 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
  5. ↑ Droin N, Beauchemin M, Solary E, Bertrand R (December 2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade". Cancer Res. 60 (24): 7039–47. PMID 11156409.

External links

Further reading

  • Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Chou JJ, Matsuo H, Duan H, Wagner G (1998). "Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment". Cell. 94 (2): 171–80. doi:10.1016/S0092-8674(00)81417-8. PMID 9695946.
  • Horvat S, Medrano JF (1998). "A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region". Genomics. 54 (1): 159–64. doi:10.1006/geno.1998.5540. PMID 9806843.
  • Shearwin-Whyatt LM, Harvey NL, Kumar S (2000). "Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD". Cell Death Differ. 7 (2): 155–65. doi:10.1038/sj.cdd.4400632. PMID 10713730.
  • Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
  • Droin N, Beauchemin M, Solary E, Bertrand R (2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade". Cancer Res. 60 (24): 7039–47. PMID 11156409.
  • Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. 277 (16): 13430–7. doi:10.1074/jbc.M108029200. PMID 11832478.
  • Tinel A, Tschopp J (2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science. 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Park HH, Wu H (2006). "Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly". J. Mol. Biol. 357 (2): 358–64. doi:10.1016/j.jmb.2005.12.082. PMC 2902980. PMID 16434054.
  • Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B (2006). "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage". Oncogene. 25 (41): 5683–92. doi:10.1038/sj.onc.1209569. PMID 16652156.
  • Park HH, Wu H (2007). "Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD". Acta Crystallographica Section F. 63 (Pt 3): 229–32. doi:10.1107/S1744309107007889. PMC 2330181. PMID 17329820.


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