Alpha-N-acetylglucosaminidase: Difference between revisions
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'''Alpha-N-acetylglucosaminidase''' ({{EC number|3.2.1.50}}, ''alpha-acetylglucosaminidase'', ''N-acetyl-alpha-D-glucosaminidase'', ''N-acetyl-alpha-glucosaminidase'', ''alpha-D-2-acetamido-2-deoxyglucosidase'') is a [[protein]] associated with [[Sanfilippo syndrome]]. It is an [[enzyme]] with [[List of enzymes|systematic name]] ''alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase''.<ref>{{cite journal | title = Human | '''Alpha-N-acetylglucosaminidase''' ({{EC number|3.2.1.50}}, ''alpha-acetylglucosaminidase'', ''N-acetyl-alpha-D-glucosaminidase'', ''N-acetyl-alpha-glucosaminidase'', ''alpha-D-2-acetamido-2-deoxyglucosidase'') is a [[protein]] associated with [[Sanfilippo syndrome]]. It is an [[enzyme]] with [[List of enzymes|systematic name]] ''alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase''.<ref>{{cite journal | vauthors = von Figura K | title = Human alpha-N-acetylglucosaminidase. 1. Purification and properties | journal = European Journal of Biochemistry | volume = 80 | issue = 2 | pages = 523–33 | date = November 1977 | pmid = 411658 | doi = 10.1111/j.1432-1033.1977.tb11908.x }}</ref><ref>{{cite journal | vauthors = von Figura K | title = Human alpha-n-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms | journal = European Journal of Biochemistry | volume = 80 | issue = 2 | pages = 535–42 | date = November 1977 | pmid = 923593 | doi = 10.1111/j.1432-1033.1977.tb11909.x }}</ref><ref>{{cite journal | vauthors = Weissmann B, Rowin G, Marshall J, Friederici D | title = Mammalian alpha-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization | journal = Biochemistry | volume = 6 | issue = 1 | pages = 207–14 | date = January 1967 | pmid = 4291567 | doi = 10.1021/bi00853a033 }}</ref><ref>{{cite journal | vauthors = Werries E, Wollek E, Gottschalk A, Buddecke E | title = Separation of N-acetyl-alpha-glucosaminidase and N-acetyl-alpha-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-alpha-galactosaminidase | journal = European Journal of Biochemistry | volume = 10 | issue = 3 | pages = 445–9 | date = October 1969 | pmid = 5348072 | doi = 10.1111/j.1432-1033.1969.tb00709.x }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]] | ||
: [[Hydrolysis]] of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides | : [[Hydrolysis]] of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides | ||
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{{reflist}} | {{reflist}} | ||
==External links== | == External links == | ||
* {{MeshName|alpha-N-acetyl-D-glucosaminidase}} | * {{MeshName|alpha-N-acetyl-D-glucosaminidase}} | ||
Latest revision as of 04:59, 20 March 2018
| N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) | |
|---|---|
| Identifiers | |
| Symbol | NAGLU |
| Entrez | 4669 |
| HUGO | 7632 |
| OMIM | 609701 |
| RefSeq | NM_000263 |
| UniProt | P54802 |
| Other data | |
| EC number | 3.2.1.50 |
| Locus | Chr. 17 q11-q21 |
Alpha-N-acetylglucosaminidase (EC 3.2.1.50, alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, alpha-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome. It is an enzyme with systematic name alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides
This enzyme hydrolyses UDP-N-acetylglucosamine.
References
- ↑ von Figura K (November 1977). "Human alpha-N-acetylglucosaminidase. 1. Purification and properties". European Journal of Biochemistry. 80 (2): 523–33. doi:10.1111/j.1432-1033.1977.tb11908.x. PMID 411658.
- ↑ von Figura K (November 1977). "Human alpha-n-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms". European Journal of Biochemistry. 80 (2): 535–42. doi:10.1111/j.1432-1033.1977.tb11909.x. PMID 923593.
- ↑ Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). "Mammalian alpha-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization". Biochemistry. 6 (1): 207–14. doi:10.1021/bi00853a033. PMID 4291567.
- ↑ Werries E, Wollek E, Gottschalk A, Buddecke E (October 1969). "Separation of N-acetyl-alpha-glucosaminidase and N-acetyl-alpha-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-alpha-galactosaminidase". European Journal of Biochemistry. 10 (3): 445–9. doi:10.1111/j.1432-1033.1969.tb00709.x. PMID 5348072.
External links
- alpha-N-acetyl-D-glucosaminidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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