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{{Infobox_gene}}
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'''Epsin-2''' is a [[protein]] that in humans is encoded by the ''EPN2'' [[gene]].<ref name="pmid10567358">{{cite journal | vauthors = Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P | title = The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module | journal = J Biol Chem | volume = 274 | issue = 48 | pages = 33959–65 |date=Dec 1999 | pmid = 10567358 | pmc =  | doi =10.1074/jbc.274.48.33959 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EPN2 epsin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22905| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Epsin 2
| HGNCid = 18639
| Symbol = EPN2
| AltSymbols =; EHB21; KIAA1065
| OMIM = 607263
| ECnumber =
| Homologene = 40710
| MGIid = 1333766
  | GeneAtlas_image1 = PBB_GE_EPN2_203463_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EPN2_203464_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0008289 |text = lipid binding}}  
| Component =
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22905
    | Hs_Ensembl = ENSG00000072134
    | Hs_RefseqProtein = NP_055779
    | Hs_RefseqmRNA = NM_014964
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 19081303
    | Hs_GenLoc_end = 19180620
    | Hs_Uniprot = O95208
    | Mm_EntrezGene = 13855
    | Mm_Ensembl = ENSMUSG00000001036
    | Mm_RefseqmRNA = XM_992228
    | Mm_RefseqProtein = XP_997322
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 61333444
    | Mm_GenLoc_end = 61395858
    | Mm_Uniprot = Q5NCM4
  }}
}}
'''Epsin 2''', also known as '''EPN2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EPN2 epsin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22905| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: EPN2 epsin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22905| accessdate = }}</ref>
| summary_text = This gene encodes a protein which interacts with [[clathrin]] and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated [[vesicle (biology and chemistry)|vesicle]] fraction and localizes to the [[Golgi apparatus|peri-Golgi region]] and the [[cell (biology)|cell]] periphery. The protein is thought to be involved in [[clathrin-mediated endocytosis]]. Alternate splicing of this gene results in two [[transcript variants]] encoding different [[isoforms]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Salcini AE, Confalonieri S, Doria M, ''et al.'' |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239-49 |year= 1997 |pmid= 9303539 |doi=  }}
*{{cite journal  | vauthors=Salcini AE, Confalonieri S, Doria M |title=Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi=10.1101/gad.11.17.2239  | pmc=275390 |display-authors=etal}}
*{{cite journal  | author=Yamabhai M, Hoffman NG, Hardison NL, ''et al.'' |title=Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 31401-7 |year= 1998 |pmid= 9813051 |doi=  }}
*{{cite journal  | vauthors=Yamabhai M, Hoffman NG, Hardison NL |title=Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 31401–7 |year= 1998 |pmid= 9813051 |doi=10.1074/jbc.273.47.31401 |display-authors=etal}}
*{{cite journal  | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi= }}
*{{cite journal  | vauthors=Kikuno R, Nagase T, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197  |display-authors=etal}}
*{{cite journal  | author=Rosenthal JA, Chen H, Slepnev VI, ''et al.'' |title=The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 33959-65 |year= 1999 |pmid= 10567358 |doi= }}
*{{cite journal  | vauthors=Ford MG, Mills IG, Peter BJ |title=Curvature of clathrin-coated pits driven by epsin |journal=Nature |volume=419 |issue= 6905 |pages= 361–6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020 |display-authors=etal}}
*{{cite journal  | author=Ford MG, Mills IG, Peter BJ, ''et al.'' |title=Curvature of clathrin-coated pits driven by epsin. |journal=Nature |volume=419 |issue= 6905 |pages= 361-6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hussain NK, Yamabhai M, Bhakar AL |title=A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28823–30 |year= 2003 |pmid= 12750376 |doi= 10.1074/jbc.M300995200 |display-authors=etal}}
*{{cite journal  | author=Hussain NK, Yamabhai M, Bhakar AL, ''et al.'' |title=A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28823-30 |year= 2003 |pmid= 12750376 |doi= 10.1074/jbc.M300995200 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 17:13, 21 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Epsin-2 is a protein that in humans is encoded by the EPN2 gene.[1][2]

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[2]

References

  1. ↑ Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P (Dec 1999). "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J Biol Chem. 274 (48): 33959–65. doi:10.1074/jbc.274.48.33959. PMID 10567358.
  2. ↑ 2.0 2.1 "Entrez Gene: EPN2 epsin 2".

Further reading



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