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{{Infobox_gene}}
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'''Tax1-binding protein 3''' is a [[protein]] that in humans is encoded by the ''TAX1BP3'' [[gene]].<ref name="pmid8619474">{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal Biochem | volume = 236 | issue = 1 | pages = 107–13 |date=Jun 1996 | pmid = 8619474 | pmc =  | doi = 10.1006/abio.1996.0138 }}</ref><ref name="pmid10673275">{{cite journal | vauthors = Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED | title = The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion | journal = Genome Res | volume = 10 | issue = 2 | pages = 165–73 |date=Mar 2000 | pmid = 10673275 | pmc = 310836 | doi =10.1101/gr.10.2.165 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30851| accessdate = }}</ref>  This name is in reference to the [[Tax1]] protein of the [[Human T-lymphotropic virus|Human T-cell Lymphotropic Virus]] (HTLV) which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by [[co-IP]].  TIP1, as it is also known, is a [[PDZ domain]] containing protein.  However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain.  This has led to the speculation that TIP1 acts as an [[Enzyme inhibitor|inhibitor]], either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the [[cytosol]].  
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| image = 
| image_source = 
| PDB =
| Name = Tax1 (human T-cell leukemia virus type I) binding protein 3
| HGNCid = 30684
| Symbol = TAX1BP3
| AltSymbols =; TIP-1
| OMIM = 
| ECnumber = 
| Homologene = 8749
| MGIid = 1923531
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30851
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_055419
    | Hs_RefseqmRNA = NM_014604
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 76281
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_029564
    | Mm_RefseqProtein = NP_083840
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Tax1 (human T-cell leukemia virus type I) binding protein 3''', also known as '''TAX1BP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30851| accessdate = }}</ref>  This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV)which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP.  TIP1, as it is also known, is a PDZ domain containing protein.  However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain.  This has lead to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Banerjee M, etal |title=Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif. |journal=Biochemistry |volume=51 |issue= 35 |pages= 6950–60 |year= 2012 |pmid= 22876914 |doi= 10.1021/bi3008033 |pmc=3433589}}
*{{cite journal | author=Rousset R, Fabre S, Desbois C, ''et al.'' |title=The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. |journal=Oncogene |volume=16 |issue= 5 |pages= 643-54 |year= 1998 |pmid= 9482110 |doi= 10.1038/sj.onc.1201567 }}
*{{cite journal   |vauthors=Rousset R, Fabre S, Desbois C, etal |title=The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. |journal=Oncogene |volume=16 |issue= 5 |pages= 643–54 |year= 1998 |pmid= 9482110 |doi= 10.1038/sj.onc.1201567 }}
*{{cite journal  | author=Touchman JW, Anikster Y, Dietrich NL, ''et al.'' |title=The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. |journal=Genome Res. |volume=10 |issue= 2 |pages= 165-73 |year= 2000 |pmid= 10673275 |doi=  }}
*{{cite journal  | vauthors=Reynaud C, Fabre S, Jalinot P |title=The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33962–8 |year= 2000 |pmid= 10940294 |doi= 10.1074/jbc.M000465200 }}
*{{cite journal  | author=Reynaud C, Fabre S, Jalinot P |title=The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33962-8 |year= 2000 |pmid= 10940294 |doi= 10.1074/jbc.M000465200 }}
*{{cite journal  | vauthors=Olalla L, Aledo JC, Bannenberg G, Márquez J |title=The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. |journal=FEBS Lett. |volume=488 |issue= 3 |pages= 116–22 |year= 2001 |pmid= 11163757 |doi=10.1016/S0014-5793(00)02373-5 }}
*{{cite journal  | author=Olalla L, Aledo JC, Bannenberg G, Márquez J |title=The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. |journal=FEBS Lett. |volume=488 |issue= 3 |pages= 116-22 |year= 2001 |pmid= 11163757 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kanamori M, Sandy P, Marzinotto S, etal |title=The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38758–64 |year= 2003 |pmid= 12874278 |doi= 10.1074/jbc.M306324200 }}
*{{cite journal | author=Kanamori M, Sandy P, Marzinotto S, ''et al.'' |title=The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38758-64 |year= 2003 |pmid= 12874278 |doi= 10.1074/jbc.M306324200 }}
*{{cite journal   |vauthors=Twizere JC, Kruys V, Lefèbvre L, etal |title=Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. |journal=J. Natl. Cancer Inst. |volume=95 |issue= 24 |pages= 1846–59 |year= 2004 |pmid= 14679154 |doi=  10.1093/jnci/djg118}}
*{{cite journal | author=Twizere JC, Kruys V, Lefèbvre L, ''et al.'' |title=Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. |journal=J. Natl. Cancer Inst. |volume=95 |issue= 24 |pages= 1846-59 |year= 2004 |pmid= 14679154 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Hampson L, Li C, Oliver AW, etal |title=The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1249–56 |year= 2005 |pmid= 15492812 |doi=  10.3892/ijo.25.5.1249}}
*{{cite journal | author=Hampson L, Li C, Oliver AW, ''et al.'' |title=The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1249-56 |year= 2005 |pmid= 15492812 |doi=  }}
*{{cite journal  | vauthors=Alewine C, Olsen O, Wade JB, Welling PA |title=TIP-1 has PDZ scaffold antagonist activity. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4200–11 |year= 2007 |pmid= 16855024 |doi= 10.1091/mbc.E06-02-0129 | pmc=1635354 }}
*{{cite journal  | author=Alewine C, Olsen O, Wade JB, Welling PA |title=TIP-1 has PDZ scaffold antagonist activity. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4200-11 |year= 2007 |pmid= 16855024 |doi= 10.1091/mbc.E06-02-0129 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 20:00, 15 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tax1-binding protein 3 is a protein that in humans is encoded by the TAX1BP3 gene.[1][2][3] This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV) which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.


References

  1. ↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  2. ↑ Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED (Mar 2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res. 10 (2): 165–73. doi:10.1101/gr.10.2.165. PMC 310836. PMID 10673275.
  3. ↑ "Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3".

Further reading



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