CAMKK1: Difference between revisions

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{{Infobox_gene}}
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'''Calcium/calmodulin-dependent protein kinase kinase 1''' is an [[enzyme]] that in humans is encoded by the ''CAMKK1'' [[gene]].<ref name="pmid11230166">{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res | volume = 11 | issue = 3 | pages = 422–35 |date=Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84254| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Calcium/calmodulin-dependent protein kinase kinase 1, alpha
| HGNCid = 1469
| Symbol = CAMKK1
| AltSymbols =; CAMKKA; DKFZp761M0423; MGC34095
| OMIM = 
| ECnumber = 
| Homologene = 10327
| MGIid = 1891766
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84254
    | Hs_Ensembl = ENSG00000004660
    | Hs_RefseqProtein = NP_115670
    | Hs_RefseqmRNA = NM_032294
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3710358
    | Hs_GenLoc_end = 3743087
    | Hs_Uniprot = Q8N5S9
    | Mm_EntrezGene = 55984
    | Mm_Ensembl = ENSMUSG00000020785
    | Mm_RefseqmRNA = NM_018883
    | Mm_RefseqProtein = NP_061371
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 72835238
    | Mm_GenLoc_end = 72858268
    | Mm_Uniprot = Q5SRU3
  }}
}}
'''Calcium/calmodulin-dependent protein kinase kinase 1, alpha''', also known as '''CAMKK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84254| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84254| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the [[serine/threonine protein kinase]] family, and to the [[CAMK|Ca(2+)/calmodulin-dependent protein kinase]] (CAMK) subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three [[transcript variants]] encoding two distinct [[protein isoform|isoforms]] have been identified for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CAMKK1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Selbert MA, Anderson KA, Huang QH, ''et al.'' |title=Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17616-21 |year= 1995 |pmid= 7615569 |doi=  }}
*{{cite journal  | vauthors=Selbert MA, Anderson KA, Huang QH |title=Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17616–21 |year= 1995 |pmid= 7615569 |doi=  10.1074/jbc.270.29.17616|display-authors=etal}}
*{{cite journal  | author=Tokumitsu H, Enslen H, Soderling TR |title=Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19320-4 |year= 1995 |pmid= 7642608 |doi=  }}
*{{cite journal  | vauthors=Tokumitsu H, Enslen H, Soderling TR |title=Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19320–4 |year= 1995 |pmid= 7642608 |doi=  10.1074/jbc.270.33.19320}}
*{{cite journal  | author=Tokumitsu H, Soderling TR |title=Requirements for calcium and calmodulin in the calmodulin kinase activation cascade. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5617-22 |year= 1996 |pmid= 8621423 |doi=  }}
*{{cite journal  | vauthors=Tokumitsu H, Soderling TR |title=Requirements for calcium and calmodulin in the calmodulin kinase activation cascade |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5617–22 |year= 1996 |pmid= 8621423 |doi=10.1074/jbc.271.10.5617 }}
*{{cite journal  | author=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473-81 |year= 1998 |pmid= 9705275 |doi=  }}
*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=10.1074/jbc.273.34.21473 }}
*{{cite journal  | author=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086-93 |year= 1999 |pmid= 10187789 |doi=  }}
*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086–93 |year= 1999 |pmid= 10187789 |doi=10.1074/jbc.274.15.10086 }}
*{{cite journal  | author=Lawson ND, Zain M, Zibello T, ''et al.'' |title=Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation. |journal=Exp. Hematol. |volume=27 |issue= 11 |pages= 1682-90 |year= 1999 |pmid= 10560916 |doi=  }}
*{{cite journal  | vauthors=Lawson ND, Zain M, Zibello T |title=Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation |journal=Exp. Hematol. |volume=27 |issue= 11 |pages= 1682–90 |year= 1999 |pmid= 10560916 |doi=10.1016/S0301-472X(99)00108-3 |display-authors=etal}}
*{{cite journal  | author=Okuno S, Kitani T, Matsuzaki H, ''et al.'' |title=Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases. |journal=J. Biochem. |volume=127 |issue= 6 |pages= 965-70 |year= 2000 |pmid= 10833263 |doi=  }}
*{{cite journal  | vauthors=Okuno S, Kitani T, Matsuzaki H |title=Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases |journal=J. Biochem. |volume=127 |issue= 6 |pages= 965–70 |year= 2000 |pmid= 10833263 |doi=  10.1093/oxfordjournals.jbchem.a022712|display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Okuno S, Kitani T, Fujisawa H |title=Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis |journal=J. Biochem. |volume=130 |issue= 4 |pages= 503–13 |year= 2002 |pmid= 11574070 |doi=  10.1093/oxfordjournals.jbchem.a003013}}
*{{cite journal  | author=Okuno S, Kitani T, Fujisawa H |title=Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis. |journal=J. Biochem. |volume=130 |issue= 4 |pages= 503-13 |year= 2002 |pmid= 11574070 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Imai S, Okayama N, Shimizu M, Itoh M |title=Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells |journal=Life Sci. |volume=72 |issue= 20 |pages= 2199–209 |year= 2003 |pmid= 12628440 |doi=10.1016/S0024-3205(03)00092-4 }}
*{{cite journal  | author=Imai S, Okayama N, Shimizu M, Itoh M |title=Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells. |journal=Life Sci. |volume=72 |issue= 20 |pages= 2199-209 |year= 2003 |pmid= 12628440 |doi=  }}
*{{cite journal  | vauthors=Ishikawa Y, Tokumitsu H, Inuzuka H |title=Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells |journal=FEBS Lett. |volume=550 |issue= 1–3 |pages= 57–63 |year= 2003 |pmid= 12935886 |doi=10.1016/S0014-5793(03)00817-2 |display-authors=etal}}
*{{cite journal  | author=Ishikawa Y, Tokumitsu H, Inuzuka H, ''et al.'' |title=Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. |journal=FEBS Lett. |volume=550 |issue= 1-3 |pages= 57-63 |year= 2003 |pmid= 12935886 |doi=  }}
*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 05:48, 27 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.[1][2]

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase (CAMK) subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.[2]

References

  1. ↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  2. ↑ 2.0 2.1 "Entrez Gene: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha".

External links

Further reading



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