RPH3AL: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Rab effector Noc2''' is a [[protein]] that in humans is encoded by the ''RPH3AL'' [[gene]].<ref name="pmid10395805">{{cite journal | vauthors = Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C | title = Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus | journal = Genomics | volume = 59 | issue = 1 | pages = 97–101 | date = July 1999 | pmid = 10395805 | pmc =  | doi = 10.1006/geno.1999.5864 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9501| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Rabphilin 3A-like (without C2 domains)
| HGNCid = 10296
| Symbol = RPH3AL
| AltSymbols =; NOC2
| OMIM = 604881
| ECnumber = 
| Homologene = 5078
| MGIid = 1923492
| GeneAtlas_image1 = PBB_GE_RPH3AL_221614_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017137 |text = Rab GTPase binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006887 |text = exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9501
    | Hs_Ensembl = ENSG00000181031
    | Hs_RefseqProtein = NP_008918
    | Hs_RefseqmRNA = NM_006987
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 62293
    | Hs_GenLoc_end = 202888
    | Hs_Uniprot = 
    | Mm_EntrezGene = 380714
    | Mm_Ensembl = ENSMUSG00000020847
    | Mm_RefseqmRNA = XM_358900
    | Mm_RefseqProtein = XP_358900
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 75648332
    | Mm_GenLoc_end = 75742086
    | Mm_Uniprot = 
  }}
}}
'''Rabphilin 3A-like (without C2 domains)''', also known as '''RPH3AL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9501| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
RPH3AL has been shown to [[Protein-protein interaction|interact]] with [[RAB27A]].<ref name=pmid14593078>{{cite journal | vauthors = Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R | title = The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis | journal = Molecular Endocrinology | volume = 18 | issue = 1 | pages = 117–26 | date = January 2004 | pmid = 14593078 | doi = 10.1210/me.2003-0300 }}</ref><ref name=pmid12578829>{{cite journal | vauthors = Fukuda M | title = Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15373–80 | date = April 2003 | pmid = 12578829 | doi = 10.1074/jbc.M212341200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S | title = Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 47 | pages = 29407–10 | date = November 1997 | pmid = 9367993 | doi = 10.1074/jbc.272.47.29407 }}
| citations =
* {{cite journal | vauthors = Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC | title = Piccolo, a presynaptic zinc finger protein structurally related to bassoon | journal = Neuron | volume = 25 | issue = 1 | pages = 203–14 | date = January 2000 | pmid = 10707984 | doi = 10.1016/S0896-6273(00)80883-1 }}
*{{cite journal | author=Kotake K, Ozaki N, Mizuta M, ''et al.'' |title=Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29407-10 |year= 1997 |pmid= 9367993 |doi=  }}
* {{cite journal | vauthors = Haynes LP, Evans GJ, Morgan A, Burgoyne RD | title = A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 9726–32 | date = March 2001 | pmid = 11134008 | doi = 10.1074/jbc.M006959200 }}
*{{cite journal  | author=Smith JS, Tachibana I, Allen C, ''et al.'' |title=Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus. |journal=Genomics |volume=59 |issue= 1 |pages= 97-101 |year= 1999 |pmid= 10395805 |doi= 10.1006/geno.1999.5864 }}
* {{cite journal | vauthors = Goi T, Takeuchi K, Katayama K, Hirose K, Yamaguchi A | title = Mutations of rabphillin-3A-like gene in colorectal cancers | journal = Oncology Reports | volume = 9 | issue = 6 | pages = 1189–92 | year = 2003 | pmid = 12375017 | doi = 10.3892/or.9.6.1189 }}
*{{cite journal | author=Fenster SD, Chung WJ, Zhai R, ''et al.'' |title=Piccolo, a presynaptic zinc finger protein structurally related to bassoon. |journal=Neuron |volume=25 |issue= 1 |pages= 203-14 |year= 2000 |pmid= 10707984 |doi= }}
* {{cite journal | vauthors = Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H | title = A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 4072–81 | date = February 2003 | pmid = 12446671 | doi = 10.1074/jbc.M208898200 }}
*{{cite journal | author=Haynes LP, Evans GJ, Morgan A, Burgoyne RD |title=A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9726-32 |year= 2001 |pmid= 11134008 |doi= 10.1074/jbc.M006959200 }}
* {{cite journal | vauthors = Fukuda M | title = Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15373–80 | date = April 2003 | pmid = 12578829 | doi = 10.1074/jbc.M212341200 }}
*{{cite journal | author=Goi T, Takeuchi K, Katayama K, ''et al.'' |title=Mutations of rabphillin-3A-like gene in colorectal cancers. |journal=Oncol. Rep. |volume=9 |issue= 6 |pages= 1189-92 |year= 2003 |pmid= 12375017 |doi= }}
* {{cite journal | vauthors = Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH | title = Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3 | journal = American Journal of Human Genetics | volume = 72 | issue = 4 | pages = 918–30 | date = April 2003 | pmid = 12621583 | pmc = 1180354 | doi = 10.1086/374320 }}
*{{cite journal | author=Milkereit P, Strauss D, Bassler J, ''et al.'' |title=A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 4072-81 |year= 2003 |pmid= 12446671 |doi= 10.1074/jbc.M208898200 }}
* {{cite journal | vauthors = Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R | title = The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis | journal = Molecular Endocrinology | volume = 18 | issue = 1 | pages = 117–26 | date = January 2004 | pmid = 14593078 | doi = 10.1210/me.2003-0300 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T | title = Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells | journal = Biochemical and Biophysical Research Communications | volume = 316 | issue = 1 | pages = 218–25 | date = March 2004 | pmid = 15003533 | doi = 10.1016/j.bbrc.2004.02.026 }}
*{{cite journal  | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373-80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 }}
* {{cite journal | vauthors = Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S | title = Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 22 | pages = 8313–8 | date = June 2004 | pmid = 15159548 | pmc = 420391 | doi = 10.1073/pnas.0306709101 }}
*{{cite journal | author=Cardoso C, Leventer RJ, Ward HL, ''et al.'' |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918-30 |year= 2003 |pmid= 12621583 |doi= }}
* {{cite journal | vauthors = Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U | title = Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma | journal = Frontiers in Bioscience | volume = 13 | issue = 1 | pages = 1050–61 | date = January 2008 | pmid = 17981610 | pmc = 2667692 | doi = 10.2741/2742 }}
*{{cite journal | author=Cheviet S, Coppola T, Haynes LP, ''et al.'' |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. |journal=Mol. Endocrinol. |volume=18 |issue= 1 |pages= 117-26 |year= 2004 |pmid= 14593078 |doi= 10.1210/me.2003-0300 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Manabe S, Nishimura N, Yamamoto Y, ''et al.'' |title=Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 1 |pages= 218-25 |year= 2004 |pmid= 15003533 |doi= 10.1016/j.bbrc.2004.02.026 }}
*{{cite journal | author=Matsumoto M, Miki T, Shibasaki T, ''et al.'' |title=Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 22 |pages= 8313-8 |year= 2004 |pmid= 15159548 |doi= 10.1073/pnas.0306709101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 15:57, 7 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.[1][2]

Interactions

RPH3AL has been shown to interact with RAB27A.[3][4]

References

  1. ↑ Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (July 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.
  2. ↑ "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".
  3. ↑ Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Molecular Endocrinology. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
  4. ↑ Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.

Further reading


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