RAB5C: Difference between revisions

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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Latest revision as of 09:52, 30 May 2018

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene.^[1]^[2] RAB5C belongs to the Ras-related protein family.

References

↑ Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1–2): 137–9. doi:10.1159/000134325. PMID 8646882.
↑ "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".

Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID 7951316.
Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells". J. Biol. Chem. 273 (51): 33901–4. doi:10.1074/jbc.273.51.33901. PMID 9852039.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate". Infect. Immun. 68 (5): 2671–84. doi:10.1128/IAI.68.5.2671-2684.2000. PMC 97474. PMID 10768959.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid8646882-1] Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1–2): 137–9. doi:10.1159/000134325. PMID 8646882.

[entrez-2] "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Ras-related protein Rab-5C''' is a [[protein]] that in humans is encoded by the ''RAB5C'' [[gene]].<ref name="pmid8646882">{{cite journal | vauthors = Han HJ, Sudo K, Inazawa J, Nakamura Y | title = Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene | journal = Cytogenet Cell Genet | volume = 73 | issue = 1-2 | pages = 137–9 |date=Jul 1996 | pmid = 8646882 | pmc =  | doi =10.1159/000134325  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB5C RAB5C, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5878| accessdate = }}</ref> RAB5C belongs to the [[Rap GTP-binding protein|Ras-related protein]] family.
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_RAB5C_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1huq.
- | PDB = {{PDB2|1huq}}, {{PDB2|1n6h}}, {{PDB2|1n6i}}, {{PDB2|1n6k}}, {{PDB2|1n6l}}, {{PDB2|1n6n}}, {{PDB2|1n6o}}, {{PDB2|1n6p}}, {{PDB2|1n6r}}, {{PDB2|1r2q}}, {{PDB2|1tu3}}, {{PDB2|1tu4}}, {{PDB2|1z07}}, {{PDB2|1z0d}}
- | Name = RAB5C, member RAS oncogene family
- | HGNCid = 9785
- | Symbol = RAB5C
- | AltSymbols =; MGC117217; MGC138857; RAB5CL; RABL
- | OMIM = 604037
- | ECnumber =
- | Homologene = 55533
- | MGIid = 105306
- | GeneAtlas_image1 = PBB_GE_RAB5C_201140_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RAB5C_201156_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
- | Component = {{GNF_GO|id=GO:0030139 |text = endocytic vesicle}}
- | Process = {{GNF_GO|id=GO:0007032 |text = endosome organization and biogenesis}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0030100 |text = regulation of endocytosis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5878
-    | Hs_Ensembl = ENSG00000108774
-    | Hs_RefseqProtein = NP_004574
-    | Hs_RefseqmRNA = NM_004583
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 17
-    | Hs_GenLoc_start = 37530526
-    | Hs_GenLoc_end = 37560557
-    | Hs_Uniprot = P51148
-    | Mm_EntrezGene = 19345
-    | Mm_Ensembl = ENSMUSG00000019173
-    | Mm_RefseqmRNA = NM_024456
-    | Mm_RefseqProtein = NP_077776
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 100531101
-    | Mm_GenLoc_end = 100554280
-    | Mm_Uniprot = Q3TCT9
-  }}
-}}
-'''RAB5C, member RAS oncogene family''', also known as '''RAB5C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB5C RAB5C, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5878| accessdate = }}</ref>
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@@ Line 56: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Albertsen HM, Smith SA, Mazoyer S, ''et al.'' |title=A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. |journal=Nat. Genet. |volume=7 |issue= 4 |pages= 472-9 |year= 1994 |pmid= 7951316 |doi= 10.1038/ng0894-472 }}
+*{{cite journal   |vauthors=Albertsen HM, Smith SA, Mazoyer S, etal |title=A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. |journal=Nat. Genet. |volume=7 |issue= 4 |pages= 472–9 |year= 1994 |pmid= 7951316 |doi= 10.1038/ng0894-472 }}
-*{{cite journal  | author=Han HJ, Sudo K, Inazawa J, Nakamura Y |title=Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 137-9 |year= 1996 |pmid= 8646882 |doi=  }}
+*{{cite journal  | vauthors=Alvarez-Dominguez C, Stahl PD |title=Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 33901–4 |year= 1999 |pmid= 9852039 |doi=10.1074/jbc.273.51.33901  }}
-*{{cite journal  | author=Alvarez-Dominguez C, Stahl PD |title=Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 33901-4 |year= 1999 |pmid= 9852039 |doi=  }}
+*{{cite journal   |vauthors=Bucci C, Chiariello M, Lattero D, etal |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657–62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
-*{{cite journal  | author=Bucci C, Chiariello M, Lattero D, ''et al.'' |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657-62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
+*{{cite journal  | vauthors=Clemens DL, Lee BY, Horwitz MA |title=Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. |journal=Infect. Immun. |volume=68 |issue= 5 |pages= 2671–84 |year= 2000 |pmid= 10768959 |doi=10.1128/IAI.68.5.2671-2684.2000  | pmc=97474  }}
-*{{cite journal  | author=Clemens DL, Lee BY, Horwitz MA |title=Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. |journal=Infect. Immun. |volume=68 |issue= 5 |pages= 2671-84 |year= 2000 |pmid= 10768959 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Merithew E, Stone C, Eathiraj S, Lambright DG |title=Determinants of Rab5 interaction with the N terminus of early endosome antigen 1. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8494–500 |year= 2003 |pmid= 12493736 |doi= 10.1074/jbc.M211514200 }}
-*{{cite journal  | author=Merithew E, Stone C, Eathiraj S, Lambright DG |title=Determinants of Rab5 interaction with the N terminus of early endosome antigen 1. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8494-500 |year= 2003 |pmid= 12493736 |doi= 10.1074/jbc.M211514200 }}
+*{{cite journal   |vauthors=Kajiho H, Saito K, Tsujita K, etal |title=RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. |journal=J. Cell Sci. |volume=116 |issue= Pt 20 |pages= 4159–68 |year= 2004 |pmid= 12972505 |doi= 10.1242/jcs.00718 }}
-*{{cite journal  | author=Kajiho H, Saito K, Tsujita K, ''et al.'' |title=RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. |journal=J. Cell. Sci. |volume=116 |issue= Pt 20 |pages= 4159-68 |year= 2004 |pmid= 12972505 |doi= 10.1242/jcs.00718 }}
+*{{cite journal   |vauthors=Chi A, Valencia JC, Hu ZZ, etal |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
-*{{cite journal  | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
+*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=5878}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 {{gene-17-stub}}
-{{WikiDoc Sources}}

RAB5C: Difference between revisions

Latest revision as of 09:52, 30 May 2018

References

Further reading

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