RAP1GAP2: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
 
'''RAP1 GTPase activating protein 2''' is a [[protein]] in humans that is [[Genetic code|encoded]] by the RAP1GAP2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAP1 GTPase activating protein 2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=23108 }}</ref>
'''RAP1 GTPase activating protein 2''' is a [[protein]] in humans that is [[Genetic code|encoded]] by the RAP1GAP2 [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: RAP1 GTPase activating protein 2
| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=23108
| accessdate = 2012-04-20 <!-- T08:54:34.010616-08:00 -->
}}</ref>


This gene encodes a [[GTPase-activating protein]] that [[Activator (genetics)|activates]] the small [[G protein|guanine-nucleotide-binding protein]] [[Rap1]] in [[platelet]]s. The protein interacts with [[SYTL1|synaptotagmin-like protein 1]] and [[RAB27|Rab27]] and regulates [[secretion]] of [[dense granule]]s from platelets at sites of [[endothelial]] damage. Multiple [[Alternative splicing|transcript variant]]s encoding different [[isoform]]s have been found for this gene. [provided by RefSeq, Sep 2009].
This gene encodes a [[GTPase-activating protein]] that [[Activator (genetics)|activates]] the small [[G protein|guanine-nucleotide-binding protein]] [[Rap1]] in [[platelet]]s. The protein interacts with [[SYTL1|synaptotagmin-like protein 1]] and [[RAB27|Rab27]] and regulates [[secretion]] of [[dense granule]]s from platelets at sites of [[endothelial]] damage. Multiple [[Alternative splicing|transcript variant]]s encoding different [[isoform]]s have been found for this gene. [provided by RefSeq, Sep 2009].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
 
* {{cite journal | vauthors = Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP | title = Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets | journal = Blood | volume = 114 | issue = 7 | pages = 1396–404 | date = August 2009 | pmid = 19528539 | pmc = | doi = 10.1182/blood-2008-05-155234 }}
*{{Cite journal  
* {{cite journal | vauthors = Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH | title = GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease | journal = BMC Cardiovascular Disorders | volume = 11 | pages = 29 | date = June 2011 | pmid = 21658281 | pmc = 3141757 | doi = 10.1186/1471-2261-11-29 }}
| last1 = Neumuller | first1 = O.
* {{cite journal | vauthors = Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M | title = Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes | journal = Experimental Cell Research | volume = 300 | issue = 1 | pages = 84–93 | date = October 2004 | pmid = 15383317 | pmc = | doi = 10.1016/j.yexcr.2004.07.011 }}
| last2 = Hoffmeister | first2 = M.
* {{cite journal | vauthors = Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F | title = p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1 | journal = Cardiovascular Research | volume = 92 | issue = 1 | pages = 149–58 | date = October 2011 | pmid = 21632882 | pmc = | doi = 10.1093/cvr/cvr154 }}
| last3 = Babica | first3 = J.
* {{cite journal | vauthors = Schultess J, Danielewski O, Smolenski AP | title = Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets | journal = Blood | volume = 105 | issue = 8 | pages = 3185–92 | date = April 2005 | pmid = 15632203 | pmc = | doi = 10.1182/blood-2004-09-3605 }}
| last4 = Prelle | first4 = C.
* {{cite journal | vauthors = Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP | title = Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets | journal = The Journal of Biological Chemistry | volume = 283 | issue = 4 | pages = 2297–306 | date = January 2008 | pmid = 18039662 | pmc = | doi = 10.1074/jbc.M706825200 | url = http://researchrepository.ucd.ie/bitstream/10197/5865/1/RG2-1433-JBC_revision_final.pdf }}
| last5 = Gegenbauer | first5 = K.
| last6 = Smolenski | first6 = A. P.
| doi = 10.1182/blood-2008-05-155234
| title = Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets  
| journal = Blood  
| volume = 114  
| issue = 7  
| pages = 1396–1404
| year = 2009  
| pmid = 19528539  
| pmc =  
}}
*{{Cite journal  
| last1 = Aouizerat | first1 = B. E.
| last2 = Vittinghoff | first2 = E.
| last3 = Musone | first3 = S. L.
| last4 = Pawlikowska | first4 = L.
| last5 = Kwok | first5 = P. Y.
| last6 = Olgin | first6 = J. E.
| last7 = Tseng | first7 = Z. H.
| title = GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease  
| doi = 10.1186/1471-2261-11-29
| journal = BMC Cardiovascular Disorders  
| volume = 11  
| pages = 29  
| year = 2011  
| pmid = 21658281  
| pmc =3141757  
}}
*{{Cite journal  
| last1 = Balduini | first1 = A.
| last2 = Pecci | first2 = A.
| last3 = Lova | first3 = P.
| last4 = Arezzi | first4 = N.
| last5 = Marseglia | first5 = C.
| last6 = Bellora | first6 = F.
| last7 = Perotti | first7 = C.
| last8 = Balduini | first8 = C.
| last9 = Balduini | first9 = C. L.
| doi = 10.1016/j.yexcr.2004.07.011
| last10 = Torti | first10 = M.
| title = Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes  
| journal = Experimental Cell Research  
| volume = 300  
| issue = 1  
| pages = 84–93  
| year = 2004  
| pmid = 15383317  
| pmc =  
}}
*{{Cite journal  
| last1 = Kimura | first1 = T.
| last2 = Mogi | first2 = C.
| last3 = Sato | first3 = K.
| last4 = Tomura | first4 = H.
| last5 = Ohta | first5 = H.
| last6 = Im | first6 = D. -S.
| last7 = Kuwabara | first7 = A.
| last8 = Kurose | first8 = H.
| last9 = Murakami | first9 = M.
| doi = 10.1093/cvr/cvr154
| last10 = Okajima | first10 = F.
| title = P2y5/LPA6 attenuates LPA1-mediated VE-cadherin translocation and cell-cell dissociation through G12/13 protein-Src-Rap1  
| journal = Cardiovascular Research  
| volume = 92  
| issue = 1  
| pages = 149–158
| year = 2011  
| pmid = 21632882  
| pmc =  
}}
*{{Cite journal  
| last1 = Schultess | first1 = J.
| last2 = Danielewski | first2 = O.
| last3 = Smolenski | first3 = A. P.
| doi = 10.1182/blood-2004-09-3605
| title = Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets  
| journal = Blood  
| volume = 105  
| issue = 8  
| pages = 3185–3192
| year = 2005  
| pmid = 15632203  
| pmc =  
}}
*{{Cite journal  
| last1 = Hoffmeister | first1 = M.
| last2 = Riha | first2 = P.
| last3 = Neumuller | first3 = O.
| last4 = Danielewski | first4 = O.
| last5 = Schultess | first5 = J.
| last6 = Smolenski | first6 = A. P.
| doi = 10.1074/jbc.M706825200
| title = Cyclic Nucleotide-dependent Protein Kinases Inhibit Binding of 14-3-3 to the GTPase-activating Protein Rap1GAP2 in Platelets
| journal = Journal of Biological Chemistry  
| volume = 283  
| issue = 4  
| pages = 2297–2306
| year = 2007
| pmid = 18039662  
| pmc =  
}}
 
{{refend}}
{{refend}}


{{gene-17-stub}}
{{gene-17-stub}}

Latest revision as of 20:11, 29 April 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.[1]

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

References

  1. ↑ "Entrez Gene: RAP1 GTPase activating protein 2".

Further reading

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