Apolipoprotein C2: Difference between revisions

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__NOTOC__
{{Infobox_gene}}
{{PBB|geneid=344}}
{{Infobox protein family
{{Infobox protein family
| Symbol = Apo-CII
| Symbol = Apo-CII
| Name = Apo-CII
| Name = Apo-CII
| image = PDB 1i5j EBI.jpg
| image = 1i5j.jpg
| width =
| width = 270
| caption = nmr structure of human apolipoprotein c-ii in the presence of sds
| caption = nmr structure of human apolipoprotein c-ii in the presence of sds
| Pfam = PF05355
| Pfam = PF05355
| Pfam_clan =  
| Pfam_clan =
| InterPro = IPR008019
| InterPro = IPR008019
| SMART =
| SMART =  
| PROSITE =
| PROSITE =  
| MEROPS =
| MEROPS =  
| SCOP = 1by6
| SCOP = 1by6
| TCDB =
| TCDB =  
| OPM family =
| OPM family =  
| OPM protein =
| OPM protein =  
| CAZy =
| CAZy =  
| CDD =
| CDD =  
}}
}}
{{SI}}
'''Apolipoprotein C2''' or '''apolipoprotein C-II''' is a [[protein]] that in humans is encoded by the ''APOC2'' [[gene]].
{{CMG}}
==Overview==
 
'''Apolipoprotein C2''' or '''Apolipoprotein C-II''' is a [[protein]] that in humans is encoded by the ''APOC2'' [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =
| section_title =  
| summary_text = The protein encoded by this gene is secreted in plasma where it is a component of [[very low density lipoprotein]]s and [[chylomicron]]s. This protein activates the enzyme [[lipoprotein lipase]] in capillaries<ref name="pmid16314153">{{cite journal |author=Kim SY, Park SM, Lee ST |title=Apolipoprotein C-II is a novel substrate for matrix metalloproteinases |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue=1 |pages=47–54 |year=2006 |pmid=16314153 |doi=10.1016/j.bbrc.2005.10.182}}</ref>, which hydrolyzes triglycerides and thus provides free [[fatty acid]]s for cells. Mutations in this gene cause [[Familial apoprotein CII deficiency|hyperlipoproteinemia type IB]], characterized by [[hypertriglyceridemia]], [[xanthoma]]s, and increased risk of [[pancreatitis]] and early [[atherosclerosis]].<ref name="entrez">{{cite web | title = Entrez Gene: APOC2 apolipoprotein C-II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is secreted in plasma where it is a component of [[very low density lipoprotein]]s and [[chylomicron]]s. This protein activates the enzyme [[lipoprotein lipase]] in capillaries,<ref name="pmid16314153">{{cite journal |vauthors=Kim SY, Park SM, Lee ST |title=Apolipoprotein C-II is a novel substrate for matrix metalloproteinases |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue=1 |pages=47–54 |year=2006 |pmid=16314153 |doi=10.1016/j.bbrc.2005.10.182}}</ref> which hydrolyzes triglycerides and thus provides free [[fatty acid]]s for cells. Mutations in this gene cause [[Familial apoprotein CII deficiency|hyperlipoproteinemia type IB]], characterized by [[xanthoma]]s, [[pancreatitis]], and hepatosplenomegaly, but no increased risk for [[atherosclerosis]]. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons<ref name="entrez">{{cite web | title = Entrez Gene: APOC2 apolipoprotein C-II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB_Further_reading  
| citations =
| citations =  
*{{cite journal  | author=Jackson RL, Baker HN, Gilliam EB, Gotto AM |title=Primary structure of very low density apolipoprotein C-II of human plasma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=74 |issue= 5 |pages= 1942–5 |year= 1977 |pmid= 194244 |doi=10.1073/pnas.74.5.1942  | pmc=431048  }}
*{{cite journal  |vauthors=Jackson RL, Baker HN, Gilliam EB, Gotto AM |title=Primary structure of very low density apolipoprotein C-II of human plasma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=74 |issue= 5 |pages= 1942–5 |year= 1977 |pmid= 194244 |doi=10.1073/pnas.74.5.1942  | pmc=431048  }}
*{{cite journal  | author=Lycksell PO, Ohman A, Bengtsson-Olivecrona G, ''et al.'' |title=Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. |journal=Eur. J. Biochem. |volume=205 |issue= 1 |pages= 223–31 |year= 1992 |pmid= 1555583 |doi=10.1111/j.1432-1033.1992.tb16772.x  }}
*{{cite journal  |vauthors=Lycksell PO, Ohman A, Bengtsson-Olivecrona G |title=Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. |journal=Eur. J. Biochem. |volume=205 |issue= 1 |pages= 223–31 |year= 1992 |pmid= 1555583 |doi=10.1111/j.1432-1033.1992.tb16772.x  |display-authors=etal}}
*{{cite journal  | author=Hegele RA, Connelly PW, Maguire GF, ''et al.'' |title=An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia. |journal=Dis. Markers |volume=9 |issue= 2 |pages= 73–80 |year= 1992 |pmid= 1782747  }}
*{{cite journal  |vauthors=Hegele RA, Connelly PW, Maguire GF |title=An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia. |journal=Dis. Markers |volume=9 |issue= 2 |pages= 73–80 |year= 1992 |pmid= 1782747  |display-authors=etal}}
*{{cite journal  | author=Crecchio C, Capurso A, Pepe G |title=Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency (Apo CII-Bari). |journal=Biochem. Biophys. Res. Commun. |volume=168 |issue= 3 |pages= 1118–27 |year= 1990 |pmid= 1971748 |doi=10.1016/0006-291X(90)91145-I  }}
*{{cite journal  |vauthors=Crecchio C, Capurso A, Pepe G |title=Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency (Apo CII-Bari). |journal=Biochem. Biophys. Res. Commun. |volume=168 |issue= 3 |pages= 1118–27 |year= 1990 |pmid= 1971748 |doi=10.1016/0006-291X(90)91145-I  }}
*{{cite journal  | author=Bengtsson-Olivecrona G, Sletten K |title=Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing. |journal=Eur. J. Biochem. |volume=192 |issue= 2 |pages= 515–21 |year= 1990 |pmid= 2209608 |doi=10.1111/j.1432-1033.1990.tb19255.x  }}
*{{cite journal  |vauthors=Bengtsson-Olivecrona G, Sletten K |title=Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing. |journal=Eur. J. Biochem. |volume=192 |issue= 2 |pages= 515–21 |year= 1990 |pmid= 2209608 |doi=10.1111/j.1432-1033.1990.tb19255.x  }}
*{{cite journal  | author=Wei CF, Tsao YK, Robberson DL, ''et al.'' |title=The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes. |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15211–21 |year= 1986 |pmid= 2415514 |doi=  }}
*{{cite journal  |vauthors=Wei CF, Tsao YK, Robberson DL |title=The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes. |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15211–21 |year= 1986 |pmid= 2415514 |doi=  |display-authors=etal}}
*{{cite journal  | author=Fojo SS, Lohse P, Parrott C, ''et al.'' |title=A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency. |journal=J. Clin. Invest. |volume=84 |issue= 4 |pages= 1215–9 |year= 1989 |pmid= 2477392 |doi=10.1172/JCI114287  | pmc=329780  }}
*{{cite journal  |vauthors=Fojo SS, Lohse P, Parrott C |title=A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency. |journal=J. Clin. Invest. |volume=84 |issue= 4 |pages= 1215–9 |year= 1989 |pmid= 2477392 |doi=10.1172/JCI114287  | pmc=329780  |display-authors=etal}}
*{{cite journal  | author=Jackson CL, Bruns GA, Breslow JL |title=Isolation of cDNA and genomic clones for apolipoprotein C-II. |journal=Meth. Enzymol. |volume=128 |issue=  |pages= 788–800 |year= 1986 |pmid= 3014272 |doi=10.1016/0076-6879(86)28106-9  }}
*{{cite journal  |vauthors=Jackson CL, Bruns GA, Breslow JL |title=Isolation of cDNA and genomic clones for apolipoprotein C-II |journal=Meth. Enzymol. |volume=128 |issue=  |pages= 788–800 |year= 1986 |pmid= 3014272 |doi=10.1016/0076-6879(86)28106-9 | series=Methods in Enzymology  | isbn=9780121820282 }}
*{{cite journal  | author=Fojo SS, Law SW, Brewer HB |title=The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization. |journal=FEBS Lett. |volume=213 |issue= 1 |pages= 221–6 |year= 1987 |pmid= 3030808 |doi=10.1016/0014-5793(87)81495-3  }}
*{{cite journal  |vauthors=Fojo SS, Law SW, Brewer HB |title=The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization |journal=FEBS Lett. |volume=213 |issue= 1 |pages= 221–6 |year= 1987 |pmid= 3030808 |doi=10.1016/0014-5793(87)81495-3  }}
*{{cite journal  | author=Fojo SS, Stalenhoef AF, Marr K, ''et al.'' |title=A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II. |journal=J. Biol. Chem. |volume=263 |issue= 34 |pages= 17913–6 |year= 1989 |pmid= 3192518 |doi=  }}
*{{cite journal  |vauthors=Fojo SS, Stalenhoef AF, Marr K |title=A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II |journal=J. Biol. Chem. |volume=263 |issue= 34 |pages= 17913–6 |year= 1989 |pmid= 3192518 |doi=  |display-authors=etal}}
*{{cite journal  | author=Fojo SS, Beisiegel U, Beil U, ''et al.'' |title=Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency. |journal=J. Clin. Invest. |volume=82 |issue= 5 |pages= 1489–94 |year= 1988 |pmid= 3263393 |doi=10.1172/JCI113756  | pmc=442713  }}
*{{cite journal  |vauthors=Fojo SS, Beisiegel U, Beil U |title=Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency |journal=J. Clin. Invest. |volume=82 |issue= 5 |pages= 1489–94 |year= 1988 |pmid= 3263393 |doi=10.1172/JCI113756  | pmc=442713  |display-authors=etal}}
*{{cite journal  | author=Connelly PW, Maguire GF, Hofmann T, Little JA |title=Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 1 |pages= 270–3 |year= 1987 |pmid= 3467353 |doi=10.1073/pnas.84.1.270  | pmc=304185  }}
*{{cite journal  |vauthors=Connelly PW, Maguire GF, Hofmann T, Little JA |title=Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 1 |pages= 270–3 |year= 1987 |pmid= 3467353 |doi=10.1073/pnas.84.1.270  | pmc=304185  }}
*{{cite journal  | author=Fairwell T, Hospattankar AV, Brewer HB, Khan SA |title=Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 14 |pages= 4796–800 |year= 1987 |pmid= 3474626 |doi=10.1073/pnas.84.14.4796  | pmc=305192  }}
*{{cite journal  |vauthors=Fairwell T, Hospattankar AV, Brewer HB, Khan SA |title=Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 14 |pages= 4796–800 |year= 1987 |pmid= 3474626 |doi=10.1073/pnas.84.14.4796  | pmc=305192  }}
*{{cite journal  | author=Fojo SS, Taam L, Fairwell T, ''et al.'' |title=Human preproapolipoprotein C-II. Analysis of major plasma isoforms. |journal=J. Biol. Chem. |volume=261 |issue= 21 |pages= 9591–4 |year= 1986 |pmid= 3525527 |doi=  }}
*{{cite journal  |vauthors=Fojo SS, Taam L, Fairwell T |title=Human preproapolipoprotein C-II. Analysis of major plasma isoforms |journal=J. Biol. Chem. |volume=261 |issue= 21 |pages= 9591–4 |year= 1986 |pmid= 3525527 |doi=  |display-authors=etal}}
*{{cite journal  | author=Das HK, Jackson CL, Miller DA, ''et al.'' |title=The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron. |journal=J. Biol. Chem. |volume=262 |issue= 10 |pages= 4787–93 |year= 1987 |pmid= 3558370 |doi=  }}
*{{cite journal  |vauthors=Das HK, Jackson CL, Miller DA |title=The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron |journal=J. Biol. Chem. |volume=262 |issue= 10 |pages= 4787–93 |year= 1987 |pmid= 3558370 |doi=  |display-authors=etal}}
*{{cite journal  | author=Connelly PW, Maguire GF, Little JA |title=Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease. |journal=J. Clin. Invest. |volume=80 |issue= 6 |pages= 1597–606 |year= 1988 |pmid= 3680515 |doi=10.1172/JCI113246  | pmc=442428  }}
*{{cite journal  |vauthors=Connelly PW, Maguire GF, Little JA |title=Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease |journal=J. Clin. Invest. |volume=80 |issue= 6 |pages= 1597–606 |year= 1988 |pmid= 3680515 |doi=10.1172/JCI113246  | pmc=442428  }}
*{{cite journal  | author=Baggio G, Manzato E, Gabelli C, ''et al.'' |title=Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients. |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 520–7 |year= 1986 |pmid= 3944267 |doi=10.1172/JCI112332  | pmc=423374  }}
*{{cite journal  |vauthors=Baggio G, Manzato E, Gabelli C |title=Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 520–7 |year= 1986 |pmid= 3944267 |doi=10.1172/JCI112332  | pmc=423374  |display-authors=etal}}
*{{cite journal  | author=Menzel HJ, Kane JP, Malloy MJ, Havel RJ |title=A variant primary structure of apolipoprotein C-II in individuals of African descent. |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 595–601 |year= 1986 |pmid= 3944271 |doi=10.1172/JCI112342  | pmc=423392  }}
*{{cite journal  |vauthors=Menzel HJ, Kane JP, Malloy MJ, Havel RJ |title=A variant primary structure of apolipoprotein C-II in individuals of African descent |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 595–601 |year= 1986 |pmid= 3944271 |doi=10.1172/JCI112342  | pmc=423392  }}
*{{cite journal  | author=Sharpe CR, Sidoli A, Shelley CS, ''et al.'' |title=Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. |journal=Nucleic Acids Res. |volume=12 |issue= 9 |pages= 3917–32 |year= 1984 |pmid= 6328445 |doi=10.1093/nar/12.9.3917  | pmc=318799  }}
*{{cite journal  |vauthors=Sharpe CR, Sidoli A, Shelley CS |title=Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance |journal=Nucleic Acids Res. |volume=12 |issue= 9 |pages= 3917–32 |year= 1984 |pmid= 6328445 |doi=10.1093/nar/12.9.3917  | pmc=318799  |display-authors=etal}}
*{{cite journal  | author=Jackson CL, Bruns GA, Breslow JL |title=Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 10 |pages= 2945–9 |year= 1984 |pmid= 6328478 |doi=10.1073/pnas.81.10.2945  | pmc=345197  }}
*{{cite journal  |vauthors=Jackson CL, Bruns GA, Breslow JL |title=Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 10 |pages= 2945–9 |year= 1984 |pmid= 6328478 |doi=10.1073/pnas.81.10.2945  | pmc=345197  }}
}}
}}
{{refend}}
{{refend}}


[[ru:Аполипопротеин C2]]
==External links==
{{WH}}
* {{UCSC gene info|APOC2}}
{{WS}}
 
{{Lipoproteins}}
 
[[Category:Apolipoproteins]]

Latest revision as of 13:34, 7 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
Apo-CII
File:1i5j.jpg
nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
SymbolApo-CII
PfamPF05355
InterProIPR008019
SCOP1by6
SUPERFAMILY1by6

Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,[1] which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin Pathway edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See also

References

  1. ↑ Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153.
  2. ↑ "Entrez Gene: APOC2 apolipoprotein C-II".

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Apolipoprotein_C2&oldid=1529684"