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{{Infobox_gene}}
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'''Alpha-(1,3)-fucosyltransferase''' is an [[enzyme]] that in humans is encoded by the ''FUT6'' [[gene]].<ref name="pmid1520296">{{cite journal |vauthors=Koszdin KL, Bowen BR | title = The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand | journal = Biochem Biophys Res Commun | volume = 187 | issue = 1 | pages = 152–7 |date=Oct 1992 | pmid = 1520296 | pmc =  | doi =10.1016/S0006-291X(05)81472-X }}</ref><ref name="pmid7782074">{{cite journal | vauthors = McCurley RS, ((Recinos A III)), Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW | title = Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21 | journal = Genomics | volume = 26 | issue = 1 | pages = 142–6 |date=Jul 1995 | pmid = 7782074 | pmc =  | doi =10.1016/0888-7543(95)80094-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
| HGNCid = 4017
| Symbol = FUT6
| AltSymbols =; FLJ40754; FT1A
| OMIM = 136836
| ECnumber =
| Homologene = 34780
| MGIid =
| GeneAtlas_image1 = PBB_GE_FUT6_211465_x_at_tn.png
  | GeneAtlas_image2 = PBB_GE_FUT6_210398_x_at_tn.png
  | GeneAtlas_image3 = PBB_GE_FUT6_210399_x_at_tn.png
| Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0017060 |text = 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity}} {{GNF_GO|id=GO:0046920 |text = alpha(1,3)-fucosyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} {{GNF_GO|id=GO:0042355 |text = L-fucose catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2528
    | Hs_Ensembl = ENSG00000156413
    | Hs_RefseqProtein = NP_000141
    | Hs_RefseqmRNA = NM_000150
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 5781770
    | Hs_GenLoc_end = 5790703
    | Hs_Uniprot = P51993
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)''', also known as '''FUT6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528| accessdate = }}</ref>
| summary_text = The alpha-1,3-[[fucosyltransferase]]s constitute a large family of [[glycosyltransferase]]s with a high degree of [[Homology (biology)|homology]]. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct [[oligosaccharide]] acceptors, their sensitivity to [[N-ethylmaleimide]] inhibition, their [[cation]] requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Weston BW, Smith PL, Kelly RJ, Lowe JB |title=Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. |journal=J. Biol. Chem. |volume=267 |issue= 34 |pages= 24575-84 |year= 1992 |pmid= 1339443 |doi=  }}
*{{cite journal  |vauthors=Weston BW, Smith PL, Kelly RJ, Lowe JB |title=Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. |journal=J. Biol. Chem. |volume=267 |issue= 34 |pages= 24575–84 |year= 1992 |pmid= 1339443 |doi=  }}
*{{cite journal  | author=Koszdin KL, Bowen BR |title=The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 1 |pages= 152-7 |year= 1992 |pmid= 1520296 |doi=  }}
*{{cite journal  |vauthors=Cameron HS, Szczepaniak D, Weston BW |title=Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20112–22 |year= 1995 |pmid= 7650030 |doi=10.1074/jbc.270.34.20112 }}
*{{cite journal  | author=Cameron HS, Szczepaniak D, Weston BW |title=Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20112-22 |year= 1995 |pmid= 7650030 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=McCurley RS, Recinos A, Olsen AS, ''et al.'' |title=Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. |journal=Genomics |volume=26 |issue= 1 |pages= 142-6 |year= 1995 |pmid= 7782074 |doi= }}
*{{cite journal  |vauthors=Mollicone R, Reguigne I, Fletcher A |title=Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12662–71 |year= 1994 |pmid= 8175676 |doi=  |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Mollicone R, Reguigne I, Fletcher A, ''et al.'' |title=Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12662-71 |year= 1994 |pmid= 8175676 |doi=  }}
*{{cite journal  |vauthors=Borsig L, Imbach T, Höchli M, Berger EG |title=alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. |journal=Glycobiology |volume=9 |issue= 11 |pages= 1273–80 |year= 2000 |pmid= 10536043 |doi=10.1093/glycob/9.11.1273 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Schnyder-Candrian S, Borsig L, Moser R, Berger EG |title=Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8369–74 |year= 2000 |pmid= 10900002 |doi=10.1073/pnas.97.15.8369  | pmc=26954 }}
*{{cite journal  | author=Borsig L, Imbach T, Höchli M, Berger EG |title=alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. |journal=Glycobiology |volume=9 |issue= 11 |pages= 1273-80 |year= 2000 |pmid= 10536043 |doi=  }}
*{{cite journal  |vauthors=Kamińska J, Musielak M, Nowicka A |title=Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase. |journal=Biochimie |volume=83 |issue= 8 |pages= 739–42 |year= 2001 |pmid= 11530205 |doi=10.1016/S0300-9084(01)01306-2 |display-authors=etal}}
*{{cite journal  | author=Schnyder-Candrian S, Borsig L, Moser R, Berger EG |title=Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8369-74 |year= 2000 |pmid= 10900002 |doi=  }}
*{{cite journal  |vauthors=Roos C, Kolmer M, Mattila P, Renkonen R |title=Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3168–75 |year= 2002 |pmid= 11698403 |doi= 10.1074/jbc.M107927200 }}
*{{cite journal  | author=Kamińska J, Musielak M, Nowicka A, ''et al.'' |title=Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase. |journal=Biochimie |volume=83 |issue= 8 |pages= 739-42 |year= 2001 |pmid= 11530205 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Roos C, Kolmer M, Mattila P, Renkonen R |title=Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3168-75 |year= 2002 |pmid= 11698403 |doi= 10.1074/jbc.M107927200 }}
*{{cite journal  |vauthors=Kanoh A, Ota M, Narimatsu H, Irimura T |title=Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 3 |pages= 896–901 |year= 2003 |pmid= 12670495 |doi=10.1016/S0006-291X(03)00420-0 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Martinez-Duncker I, Michalski JC, Bauvy C |title=Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis. |journal=Glycobiology |volume=14 |issue= 1 |pages= 13–25 |year= 2004 |pmid= 14514715 |doi= 10.1093/glycob/cwh006 |display-authors=etal}}
*{{cite journal  | author=Kanoh A, Ota M, Narimatsu H, Irimura T |title=Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 3 |pages= 896-901 |year= 2003 |pmid= 12670495 |doi=  }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Martinez-Duncker I, Michalski JC, Bauvy C, ''et al.'' |title=Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis. |journal=Glycobiology |volume=14 |issue= 1 |pages= 13-25 |year= 2004 |pmid= 14514715 |doi= 10.1093/glycob/cwh006 }}
*{{cite journal  |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Higai K, Miyazaki N, Azuma Y, Matsumoto K |title=Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6069–75 |year= 2007 |pmid= 17054948 |doi= 10.1016/j.febslet.2006.09.073 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Higai K, Miyazaki N, Azuma Y, Matsumoto K |title=Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6069-75 |year= 2007 |pmid= 17054948 |doi= 10.1016/j.febslet.2006.09.073 }}
}}
}}
{{refend}}
{{refend}}


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{{Glycosyltransferases}}
 
 
{{gene-19-stub}}

Latest revision as of 13:19, 7 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.[1][2][3]

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM][3]

References

  1. ↑ Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.
  2. ↑ McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.
  3. ↑ 3.0 3.1 "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)".

Further reading



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