GAPDHS: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic''' or '''glyceraldehyde-3-phosphate dehydrogenase, testis-specific''' is an [[enzyme]] that in humans is encoded by the ''GAPDHS'' [[gene]].<ref name="pmid10714828">{{cite journal | vauthors = Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM | title = Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells | journal = Journal of Andrology | volume = 21 | issue = 2 | pages = 328–38 | date = Apr 2000 | pmid = 10714828 | doi =  10.1002/j.1939-4640.2000.tb02111.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26330| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
| HGNCid = 24864
| Symbol = GAPDHS
| AltSymbols =; GAPD2; GAPDH-2; GAPDS; HSD-35
| OMIM = 609169
| ECnumber = 
| Homologene = 56402
| MGIid = 95653
| GeneAtlas_image1 = PBB_GE_GAPDHS_202475_at_tn.png
| GeneAtlas_image2 = PBB_GE_GAPDHS_207116_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004365 |text = glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0051287 |text = NAD binding}}
| Component = {{GNF_GO|id=GO:0009434 |text = microtubule-based flagellum}}
| Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0030317 |text = sperm motility}} {{GNF_GO|id=GO:0045821 |text = positive regulation of glycolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26330
    | Hs_Ensembl = ENSG00000105679
    | Hs_RefseqProtein = NP_055179
    | Hs_RefseqmRNA = NM_014364
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 40716204
    | Hs_GenLoc_end = 40728058
    | Hs_Uniprot = O14556
    | Mm_EntrezGene = 14447
    | Mm_Ensembl = ENSMUSG00000061099
    | Mm_RefseqmRNA = NM_008085
    | Mm_RefseqProtein = NP_032111
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 30438540
    | Mm_GenLoc_end = 30452441
    | Mm_Uniprot = Q3V2I5
  }}
}}
'''Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic''', also known as '''GAPDHS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26330| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein belonging to the [[glyceraldehyde-3-phosphate dehydrogenase]] family of enzymes that play an important role in [[carbohydrate metabolism]]. Like its somatic cell counterpart, this sperm-specific enzyme functions in a [[nicotinamide adenine dinucleotide]]-dependent manner to remove hydrogen and add phosphate to [[glyceraldehyde 3-phosphate]] to form [[1,3-diphosphoglycerate]]. During [[spermiogenesis]], this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.<ref name="entrez">{{cite web | title = Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26330| accessdate = }}</ref>
}}


==References==
In melanocytic cells GAPDHS gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = Dec 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactive pathway map ==
{{GlycolysisGluconeogenesis_WP534|highlight=GAPDHS}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cooper TG, Yeung CH | title = Approaches to post-testicular contraception | journal = Asian Journal of Andrology | volume = 1 | issue = 1–2 | pages = 29–36 | date = Jun 1999 | pmid = 11225901 | doi =  }}
| citations =
* {{cite journal | vauthors = Benham FJ, Povey S | title = Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations | journal = Genomics | volume = 5 | issue = 2 | pages = 209–14 | date = Aug 1989 | pmid = 2793178 | doi = 10.1016/0888-7543(89)90048-7 }}
*{{cite journal | author=Cooper TG, Yeung CH |title=Approaches to post-testicular contraception. |journal=Asian J. Androl. |volume=1 |issue= 1-2 |pages= 29-36 |year= 2001 |pmid= 11225901 |doi=  }}
* {{cite journal | vauthors = Peterson RN, Freund M | title = Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa | journal = Biology of Reproduction | volume = 8 | issue = 3 | pages = 350–7 | date = Apr 1973 | pmid = 4349855 | doi = <!--none--> | url = http://www.biolreprod.org/content/8/3/350.full.pdf+html | format = PDF }}
*{{cite journal | author=Benham FJ, Povey S |title=Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations. |journal=Genomics |volume=5 |issue= 2 |pages= 209-14 |year= 1989 |pmid= 2793178 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Peterson RN, Freund M |title=Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa. |journal=Biol. Reprod. |volume=8 |issue= 3 |pages= 350-7 |year= 1973 |pmid= 4349855 |doi= }}
* {{cite journal | vauthors = Westhoff D, Kamp G | title = Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa | journal = Journal of Cell Science | volume = 110 | issue = 15 | pages = 1821–9 | date = Aug 1997 | pmid = 9264469 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Westhoff D, Kamp G |title=Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa. |journal=J. Cell. Sci. |volume=110 ( Pt 15) |issue= |pages= 1821-9 |year= 1997 |pmid= 9264469 |doi=  }}
* {{cite journal | vauthors = Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S | title = L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa | journal = Molecular Human Reproduction | volume = 6 | issue = 2 | pages = 127–36 | date = Feb 2000 | pmid = 10655454 | doi = 10.1093/molehr/6.2.127 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG | title = Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro | journal = Journal of Andrology | volume = 22 | issue = 3 | pages = 464–70 | year = 2001 | pmid = 11330647 | doi =  }}
*{{cite journal | author=Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S |title=L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa. |journal=Mol. Hum. Reprod. |volume=6 |issue= 2 |pages= 127-36 |year= 2000 |pmid= 10655454 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal  | author=Welch JE, Brown PL, O'Brien DA, ''et al.'' |title=Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. |journal=J. Androl. |volume=21 |issue= 2 |pages= 328-38 |year= 2000 |pmid= 10714828 |doi=  }}
* {{cite journal | vauthors = Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, Cravchik A, Ross D, Lau K, Kwok S, Chang SY, Catanese J, Sninsky J, White TJ, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Owen M, Williams J, Goate A, Grupe A | title = Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 44 | pages = 15688–93 | date = Nov 2004 | pmid = 15507493 | pmc = 524264 | doi = 10.1073/pnas.0403535101 }}
*{{cite journal | author=Bone W, Jones AR, Morin C, ''et al.'' |title=Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. |journal=J. Androl. |volume=22 |issue= 3 |pages= 464-70 |year= 2001 |pmid= 11330647 |doi=  }}
* {{cite journal | vauthors = Kodama R, Kondo T, Yokote H, Jing X, Sawada T, Hironishi M, Sakaguchi K | title = Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+) | journal = Genes to Cells | volume = 10 | issue = 12 | pages = 1211–9 | date = Dec 2005 | pmid = 16324157 | doi = 10.1111/j.1365-2443.2005.00911.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Welch JE, Barbee RR, Magyar PL, Bunch DO, O'Brien DA | title = Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis | journal = Molecular Reproduction and Development | volume = 73 | issue = 8 | pages = 1052–60 | date = Aug 2006 | pmid = 16700075 | doi = 10.1002/mrd.20235 | url = https://zenodo.org/record/1229296/files/article.pdf }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
* {{cite journal | vauthors = Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM | title = Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization | journal = Human Molecular Genetics | volume = 15 | issue = 23 | pages = 3411–9 | date = Dec 2006 | pmid = 17047026 | doi = 10.1093/hmg/ddl417 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Li Y, Nowotny P, Holmans P, ''et al.'' |title=Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15688-93 |year= 2004 |pmid= 15507493 |doi= 10.1073/pnas.0403535101 }}
*{{cite journal | author=Kodama R, Kondo T, Yokote H, ''et al.'' |title=Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+). |journal=Genes Cells |volume=10 |issue= 12 |pages= 1211-9 |year= 2006 |pmid= 16324157 |doi= 10.1111/j.1365-2443.2005.00911.x }}
*{{cite journal | author=Welch JE, Barbee RR, Magyar PL, ''et al.'' |title=Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. |journal=Mol. Reprod. Dev. |volume=73 |issue= 8 |pages= 1052-60 |year= 2007 |pmid= 16700075 |doi= 10.1002/mrd.20235 }}
*{{cite journal | author=Yatsenko AN, Roy A, Chen R, ''et al.'' |title=Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. |journal=Hum. Mol. Genet. |volume=15 |issue= 23 |pages= 3411-9 |year= 2007 |pmid= 17047026 |doi= 10.1093/hmg/ddl417 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}

Latest revision as of 21:45, 29 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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PubMed searchn/an/a
Wikidata
View/Edit Human

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.[1][2]

Function

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.[2]

In melanocytic cells GAPDHS gene expression may be regulated by MITF.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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<imagemap> Image:WP534.png
|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

  1. ↑ Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM (Apr 2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". Journal of Andrology. 21 (2): 328–38. doi:10.1002/j.1939-4640.2000.tb02111.x. PMID 10714828.
  2. ↑ 2.0 2.1 "Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic".
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=GAPDHS&oldid=1529844"