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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Minor histocompatibility protein HA-1''' is a [[protein]] that in humans is encoded by the ''HMHA1'' [[gene]].<ref name="pmid9820596">{{cite journal |vauthors=Wilke M, Pool J, den Haan JM, Goulmy E | title = Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR | journal = Tissue Antigens | volume = 52 | issue = 4 | pages = 312–317 |date=Jan 1999 | pmid = 9820596 | pmc =  | doi =10.1111/j.1399-0039.1998.tb03053.x }}</ref><ref name="pmid9039502">{{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–329 |date=May 1997 | pmid = 9039502 | pmc =  | doi =10.1093/dnares/3.5.321 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HMHA1 histocompatibility (minor) HA-1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23526| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Histocompatibility (minor) HA-1
| HGNCid = 17102
| Symbol = HMHA1
| AltSymbols =; HA-1; HLA-HA1; KIAA0223
| OMIM = 601155
| ECnumber =
| Homologene = 69120
| MGIid = 1917969
  | GeneAtlas_image1 = PBB_GE_HMHA1_212873_at_tn.png
| GeneAtlas_image2 = PBB_GE_HMHA1_217614_at_tn.png
| Function =
  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}  
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23526
    | Hs_Ensembl = ENSG00000180448
    | Hs_RefseqProtein = NP_036424
    | Hs_RefseqmRNA = NM_012292
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 1018174
    | Hs_GenLoc_end = 1037627
    | Hs_Uniprot =   
    | Mm_EntrezGene = 70719
    | Mm_Ensembl = ENSMUSG00000035697
    | Mm_RefseqmRNA = NM_027521
    | Mm_RefseqProtein = NP_081797
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79419955
    | Mm_GenLoc_end = 79434601
    | Mm_Uniprot =  
  }}
}}
'''Histocompatibility (minor) HA-1''', also known as '''HMHA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HMHA1 histocompatibility (minor) HA-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23526| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=van Lochem E, van der Keur M, Mommaas AM, ''et al.'' |title=Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells. |journal=Transpl. Immunol. |volume=4 |issue= 2 |pages= 151-7 |year= 1997 |pmid= 8843592 |doi= }}
*{{cite journal  | author=van Lochem E |title=Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells |journal=Transpl. Immunol. |volume=4 |issue= 2 |pages= 151–157 |year= 1997 |pmid= 8843592 |doi=10.1016/S0966-3274(96)80009-8 |name-list-format=vanc| author2=van der Keur M  | author3=Mommaas AM  | display-authors=3 | last4=De Gast  | first4=GC  | last5=Goulmy  | first5=E }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi=  }}
*{{cite journal  | author=Aróstegui JI |title=Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA) |journal=Tissue Antigens |volume=56 |issue= 1 |pages= 69–76 |year= 2001 |pmid= 10958358 |doi=10.1034/j.1399-0039.2000.560109.x |name-list-format=vanc| author2=Gallardo D | author3=Rodríguez-Luaces M | display-authors=3  | last4=Querol  | first4=S. | last5=Madrigal  | first5=J.A.  | last6=Garcia-Lopez  | first6=J.  | last7=Granena  | first7=A. }}
*{{cite journal  | author=Wilke M, Pool J, den Haan JM, Goulmy E |title=Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR. |journal=Tissue Antigens |volume=52 |issue= 4 |pages= 312-7 |year= 1999 |pmid= 9820596 |doi= }}
*{{cite journal  |vauthors=Kaminski WE, Piehler A, Schmitz G |title=Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 782–789 |year= 2001 |pmid= 11095984 |doi= 10.1006/bbrc.2000.3880 }}
*{{cite journal | author=Aróstegui JI, Gallardo D, Rodríguez-Luaces M, ''et al.'' |title=Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA). |journal=Tissue Antigens |volume=56 |issue= 1 |pages= 69-76 |year= 2001 |pmid= 10958358 |doi=  }}
*{{cite journal  | author=Gillespie G |title=HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand |journal=Hematol. J. |volume=1 |issue= 6 |pages= 403–10 |year= 2002 |pmid= 11920221 |doi= 10.1038/sj/thj/6200065  |name-list-format=vanc| author2=Mutis T  | author3=Schrama E  | display-authors=3  | last4=Kamp  | first4=J  | last5=Esendam  | first5=B  | last6=Falkenburg  | first6=JF  | last7=Goulmy  | first7=E  | last8=Moss | first8=P }}
*{{cite journal  | author=Kaminski WE, Piehler A, Schmitz G |title=Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 782-9 |year= 2001 |pmid= 11095984 |doi= 10.1006/bbrc.2000.3880 }}
*{{cite journal  | author=Fujii N |title=Expression of minor histocompatibility antigen, HA-1, in solid tumor cells |journal=Transplantation |volume=73 |issue= 7 |pages= 1137–1141 |year= 2002 |pmid= 11965046 |doi=10.1097/00007890-200204150-00022  |name-list-format=vanc| author2=Hiraki A  | author3=Ikeda K  | display-authors=3  | last4=Ohmura  | first4=Yasushi  | last5=Nozaki  | first5=Isao  | last6=Shinagawa  | first6=Katsuji  | last7=Ishimaru  | first7=Fumihiko  | last8=Kiura  | first8=Katsuyuki  | last9=Shimizu  | first9=Nobuyoshi  }}
*{{cite journal  | author=Gillespie G, Mutis T, Schrama E, ''et al.'' |title=HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand. |journal=Hematol. J. |volume=1 |issue= 6 |pages= 403-10 |year= 2002 |pmid= 11920221 |doi= 10.1038/sj/thj/6200065 }}
*{{cite journal  | author=Mutis T |title=Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation |journal=Blood |volume=100 |issue= 2 |pages= 547–552 |year= 2002 |pmid= 12091347 |doi= 10.1182/blood-2002-01-0024 |name-list-format=vanc| author2=Blokland E  | author3=Kester M  | display-authors=3  | last4=Schrama  | first4=E  | last5=Goulmy  | first5=E }}
*{{cite journal | author=Fujii N, Hiraki A, Ikeda K, ''et al.'' |title=Expression of minor histocompatibility antigen, HA-1, in solid tumor cells. |journal=Transplantation |volume=73 |issue= 7 |pages= 1137-41 |year= 2002 |pmid= 11965046 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Mutis T, Blokland E, Kester M, ''et al.'' |title=Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation. |journal=Blood |volume=100 |issue= 2 |pages= 547-52 |year= 2002 |pmid= 12091347 |doi= 10.1182/blood-2002-01-0024 }}
*{{cite journal  | author=Wilke M |title=Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies |journal=Hematol. J. |volume=4 |issue= 5 |pages= 315–320 |year= 2004 |pmid= 14502255 |doi= 10.1038/sj.thj.6200318 |name-list-format=vanc| author2=Dolstra H  | author3=Maas F  | display-authors=3  | last4=Pool  | first4=Jos  | last5=Brouwer  | first5=Rolf  | last6=Frederik Falkenburg  | first6=J H  | last7=Rebello  | first7=Ashok  | last8=Lamers  | first8=Femke  | last9=Schuuring  | first9=Ed }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Wilke M, Dolstra H, Maas F, ''et al.'' |title=Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies. |journal=Hematol. J. |volume=4 |issue= 5 |pages= 315-20 |year= 2004 |pmid= 14502255 |doi= 10.1038/sj.thj.6200318 }}
*{{cite journal  | author=Kotzampasaki EM |title=Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation |journal=Transplant. Proc. |volume=36 |issue= 6 |pages= 1735–1738 |year= 2005 |pmid= 15350465 |doi= 10.1016/j.transproceed.2004.06.007  |name-list-format=vanc| author2=Spyropoulou-Vlachou MS  | author3=Kalofoutis C  | display-authors=3  | last4=Vrani  | first4=V  | last5=Kalofoutis  | first5=A  | last6=Stavropoulosgiokas  | first6=C }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Mommaas B |title=Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1 |journal=Blood |volume=105 |issue= 4 |pages= 1823–1827 |year= 2005 |pmid= 15498856 |doi= 10.1182/blood-2004-07-2832  |name-list-format=vanc| author2=Stegehuis-Kamp JA  | author3=van Halteren AG  | display-authors=3  | last4=Kester  | first4=M  | last5=Enczmann  | first5=J  | last6=Wernet  | first6=P  | last7=Kögler  | first7=G  | last8=Mutis  | first8=T  | last9=Brand  | first9=A }}
*{{cite journal  | author=Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, ''et al.'' |title=Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation. |journal=Transplant. Proc. |volume=36 |issue= 6 |pages= 1735-8 |year= 2005 |pmid= 15350465 |doi= 10.1016/j.transproceed.2004.06.007 }}
*{{cite journal  | author=Harangi M |title=Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome |journal=Eur. J. Immunol. |volume=35 |issue= 1 |pages= 305–317 |year= 2005 |pmid= 15593299 |doi= 10.1002/eji.200425406  |name-list-format=vanc| author2=Kaminski WE  | author3=Fleck M  | display-authors=3  | last4=Orsó | first4=Evelyn  | last5=Zeher  | first5=Margit  | last6=Kiss  | first6=Emese  | last7=Szekanecz  | first7=Zoltán  | last8=Zilahi  | first8=Erika  | last9=Marienhagen  | first9=Jörg }}
*{{cite journal | author=Mommaas B, Stegehuis-Kamp JA, van Halteren AG, ''et al.'' |title=Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1. |journal=Blood |volume=105 |issue= 4 |pages= 1823-7 |year= 2005 |pmid= 15498856 |doi= 10.1182/blood-2004-07-2832 }}
*{{cite journal  | author=Krishnan NS |title=HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation |journal=Transplant. Proc. |volume=39 |issue= 5 |pages= 1439–1445 |year= 2007 |pmid= 17580157 |doi= 10.1016/j.transproceed.2007.02.066 |name-list-format=vanc| author2=Higgins RM  | author3=Lam FT  | display-authors=3  | last4=Kashi  | first4=H  | last5=Jobson  | first5=S  | last6=Ramaiyan  | first6=K  | last7=Rahman  | first7=M  | last8=Morris  | first8=A }}
*{{cite journal  | author=Harangi M, Kaminski WE, Fleck M, ''et al.'' |title=Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome. |journal=Eur. J. Immunol. |volume=35 |issue= 1 |pages= 305-17 |year= 2005 |pmid= 15593299 |doi= 10.1002/eji.200425406 }}
*{{cite journal | author=Krishnan NS, Higgins RM, Lam FT, ''et al.'' |title=HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation. |journal=Transplant. Proc. |volume=39 |issue= 5 |pages= 1439-45 |year= 2007 |pmid= 17580157 |doi= 10.1016/j.transproceed.2007.02.066 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-19-stub}}

Latest revision as of 09:08, 14 January 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene.[1][2][3]


References

  1. ↑ Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.
  2. ↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502.
  3. ↑ "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".

Further reading

  • van Lochem E, van der Keur M, Mommaas AM, et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells". Transpl. Immunol. 4 (2): 151–157. doi:10.1016/S0966-3274(96)80009-8. PMID 8843592.
  • Aróstegui JI, Gallardo D, Rodríguez-Luaces M, et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)". Tissue Antigens. 56 (1): 69–76. doi:10.1034/j.1399-0039.2000.560109.x. PMID 10958358.
  • Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun. 278 (3): 782–789. doi:10.1006/bbrc.2000.3880. PMID 11095984.
  • Gillespie G, Mutis T, Schrama E, et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand". Hematol. J. 1 (6): 403–10. doi:10.1038/sj/thj/6200065. PMID 11920221.
  • Fujii N, Hiraki A, Ikeda K, et al. (2002). "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells". Transplantation. 73 (7): 1137–1141. doi:10.1097/00007890-200204150-00022. PMID 11965046.
  • Mutis T, Blokland E, Kester M, et al. (2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation". Blood. 100 (2): 547–552. doi:10.1182/blood-2002-01-0024. PMID 12091347.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wilke M, Dolstra H, Maas F, et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies". Hematol. J. 4 (5): 315–320. doi:10.1038/sj.thj.6200318. PMID 14502255.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". Transplant. Proc. 36 (6): 1735–1738. doi:10.1016/j.transproceed.2004.06.007. PMID 15350465.
  • Mommaas B, Stegehuis-Kamp JA, van Halteren AG, et al. (2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. 105 (4): 1823–1827. doi:10.1182/blood-2004-07-2832. PMID 15498856.
  • Harangi M, Kaminski WE, Fleck M, et al. (2005). "Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome". Eur. J. Immunol. 35 (1): 305–317. doi:10.1002/eji.200425406. PMID 15593299.
  • Krishnan NS, Higgins RM, Lam FT, et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation". Transplant. Proc. 39 (5): 1439–1445. doi:10.1016/j.transproceed.2007.02.066. PMID 17580157.



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