GADD45GIP1: Difference between revisions

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'''Growth arrest and DNA-damage-inducible proteins-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''GADD45GIP1'' [[gene]].<ref name="pmid10441517">{{cite journal | vauthors = Horikoshi N, Cong J, Kley N, Shenk T | title = Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene | journal = Biochemical and Biophysical Research Communications | volume = 261 | issue = 3 | pages = 864–9 | date = Aug 1999 | pmid = 10441517 | pmc =  | doi = 10.1006/bbrc.1999.1123 }}</ref><ref name="pmid12482659">{{cite journal | vauthors = Görnemann J, Hofmann TG, Will H, Müller M | title = Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins | journal = Virology | volume = 303 | issue = 1 | pages = 69–78 | date = Nov 2002 | pmid = 12482659 | pmc =  | doi = 10.1006/viro.2002.1670 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90480| accessdate = }}</ref>
'''Growth arrest and DNA-damage-inducible proteins-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''GADD45GIP1'' [[gene]].<ref name="pmid10441517">{{cite journal | vauthors = Horikoshi N, Cong J, Kley N, Shenk T | title = Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene | journal = Biochemical and Biophysical Research Communications | volume = 261 | issue = 3 | pages = 864–9 | date = Aug 1999 | pmid = 10441517 | pmc =  | doi = 10.1006/bbrc.1999.1123 }}</ref><ref name="pmid12482659">{{cite journal | vauthors = Görnemann J, Hofmann TG, Will H, Müller M | title = Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins | journal = Virology | volume = 303 | issue = 1 | pages = 69–78 | date = Nov 2002 | pmid = 12482659 | pmc =  | doi = 10.1006/viro.2002.1670 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90480| accessdate = }}</ref>


GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of [[mitoribosome]]. It is essential for the translation of mitochondrial oxidative phosphorylation polypeptides in mammalian mitochondria. CRIF1 interacts with LSU proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific Crif1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.{{fact|date=January 2016}}
GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of [[mitoribosome]]. It is essential for the translation of mitochondrial [[oxidative phosphorylation]] (OXPHOS) [[polypeptides]] in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the [[mitoribosome]], and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific [[Chaperone (protein)|chaperone]] [[Tid1]]. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked [[neurodegeneration]].<ref name="KimKwon2012">{{cite journal|last1=Kim|first1=Soung Jung|last2=Kwon|first2=Min-chul|last3=Ryu|first3=Min Jeong|last4=Chung|first4=Hyo Kyun|last5=Tadi|first5=Surendar|last6=Kim|first6=Yong Kyung|last7=Man Kim|first7=Jin|last8=Lee|first8=Sang Hee|last9=Park|first9=Ji Hoon|last10=Kweon|first10=Gi Ryang|last11=Ryu|first11=Seung-Wook|last12=Jo|first12=Young Suk|last13=Lee|first13=Chul-Ho|last14=Hatakeyama|first14=Hideyuki|last15=Goto|first15=Yu-ichi|last16=Yim|first16=Yong-Hyeon|last17=Chung|first17=Jongkyeong|last18=Kong|first18=Young-Yun|last19=Shong|first19=Minho|display-authors=6|title=CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane|journal=Cell Metabolism|volume=16|issue=2|year=2012|pages=274–283|issn=15504131|doi=10.1016/j.cmet.2012.06.012}}</ref>


== Interactions ==
== Interactions ==
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{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Ahn BH, Kim TH, Bae YS | title = Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins | journal = Molecules and Cells | volume = 12 | issue = 2 | pages = 158–63 | date = Oct 2001 | pmid = 11710515 | doi =  }}
* {{cite journal | vauthors = Ahn BH, Kim TH, Bae YS | title = Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins | journal = Molecules and Cells | volume = 12 | issue = 2 | pages = 158–63 | date = Oct 2001 | pmid = 11710515 | doi =  }}
* {{cite journal | vauthors = Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M | title = CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle | journal = The Journal of Biological Chemistry | volume = 278 | issue = 30 | pages = 28079–88 | date = Jul 2003 | pmid = 12716909 | doi = 10.1074/jbc.M212835200 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M | title = CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation | journal = Molecular Endocrinology | volume = 19 | issue = 1 | pages = 12–24 | date = Jan 2005 | pmid = 15459248 | doi = 10.1210/me.2004-0107 }}
* {{cite journal | vauthors = Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M | title = CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation | journal = Molecular Endocrinology | volume = 19 | issue = 1 | pages = 12–24 | date = Jan 2005 | pmid = 15459248 | doi = 10.1210/me.2004-0107 }}

Latest revision as of 13:57, 21 July 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.[1][2][3]

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.[4]

Interactions

GADD45GIP1 has been shown to interact with GADD45G,[5] GADD45B[5] and GADD45A.[5]

References

  1. ↑ Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
  2. ↑ Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659.
  3. ↑ "Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1".
  4. ↑ Kim, Soung Jung; Kwon, Min-chul; Ryu, Min Jeong; Chung, Hyo Kyun; Tadi, Surendar; Kim, Yong Kyung; et al. (2012). "CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane". Cell Metabolism. 16 (2): 274–283. doi:10.1016/j.cmet.2012.06.012. ISSN 1550-4131.
  5. ↑ 5.0 5.1 5.2 Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.

Further reading

  • Ahn BH, Kim TH, Bae YS (Oct 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Molecules and Cells. 12 (2): 158–63. PMID 11710515.
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M (Jan 2005). "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation". Molecular Endocrinology. 19 (1): 12–24. doi:10.1210/me.2004-0107. PMID 15459248.
  • Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS (Jan 2007). "Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation". Gene. 386 (1–2): 147–53. doi:10.1016/j.gene.2006.08.023. PMID 17069992.
  • Nakayama K, Nakayama N, Wang TL, Shih Ie-M (Sep 2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Research. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.
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