FFAR2-FFAR3 receptor heteromer: Difference between revisions
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== Signal transduction == | == Signal transduction == | ||
The [[Signal transduction|signalling]] of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular [[Signal transduction#Calcium|calcium release]] and [[Arrestin beta 2]] recruitment. The heteromer also lacks the ability to inhibit the [[cAMP-dependent pathway]] but gained the ability to induce [[P38 mitogen-activated protein kinases]].<ref>{{ | The [[Signal transduction|signalling]] of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular [[Signal transduction#Calcium|calcium release]] and [[Arrestin beta 2]] recruitment. The heteromer also lacks the ability to inhibit the [[cAMP-dependent pathway]] but gained the ability to induce [[P38 mitogen-activated protein kinases]].<ref>{{cite journal | vauthors = Ang Z, Xiong D, Wu M, Ding JL | title = FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing | journal = FASEB Journal | volume = 32 | issue = 1 | pages = 289-303 | date = January 2018 | pmid = 28883043 | doi = 10.1096/fj.201700252RR | url = http://www.fasebj.org/content/early/2017/09/07/fj.201700252RR }}</ref> | ||
== References == | == References == | ||
{{Reflist| | {{Reflist|32em}} | ||
Latest revision as of 10:31, 10 February 2018
| free fatty acid receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | FFAR2 |
| Alt. symbols | GPR43, FFA2R |
| Entrez | 2867 |
| HUGO | 4501 |
| OMIM | 603823 |
| RefSeq | NM_005306 |
| UniProt | O15552 |
| Other data | |
| Locus | Chr. 19 q13.1 |
| free fatty acid receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | FFAR3 |
| Alt. symbols | GPR41, FFA3R |
| Entrez | 2865 |
| HUGO | 4499 |
| OMIM | 603821 |
| RefSeq | NM_005304 |
| UniProt | O14843 |
| Other data | |
| Locus | Chr. 19 q13.1 |
The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.
Signal transduction
The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular calcium release and Arrestin beta 2 recruitment. The heteromer also lacks the ability to inhibit the cAMP-dependent pathway but gained the ability to induce P38 mitogen-activated protein kinases.[1]
References
- ↑ Ang Z, Xiong D, Wu M, Ding JL (January 2018). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal. 32 (1): 289–303. doi:10.1096/fj.201700252RR. PMID 28883043.