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{{Infobox_gene}}
{{Infobox_gene}}
'''HSD3B1''' is a human [[gene]] that encodes for a [[3-beta-HSD|3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase]] type I or '''hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1'''.<ref>{{cite web | title = Entrez Gene: HSD3B1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3283| accessdate = }}</ref> While it can carry out the same function as [[HSD3B2]], it localizes primarily to different tissues, such as the [[placenta]] and nonsteroidogenic tissues. Its requirement for the production of [[progesterone]] by the placenta, which has a vital role in pregnancy, may be one reason why no disease based on mutations in this gene has been identified to date.
'''HSD3B1''' is a human [[gene]] that encodes for a [[3-beta-HSD|3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase]] type I or '''hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1'''.<ref>{{cite web | title = Entrez Gene: HSD3B1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3283| access-date = }}</ref> While it can carry out the same function as [[HSD3B2]], it localizes primarily to different tissues, such as the [[placenta]] and nonsteroidogenic tissues. Its requirement for the production of [[progesterone]] by the placenta, which has a vital role in pregnancy, may be one reason why no disease based on mutations in this gene has been identified to date.


==Clinical significance==
==Clinical significance==
The 1245C allele is associated with poorer outcomes in [[prostate cancer]].<ref>[http://www.oncotherapynetwork.com/genitourinary-cancer-targets/researchers-identify-genetic-mutation-associated-poor-outcomes-prostate-cancer Researchers Identify Genetic Mutation Associated With Poor Outcomes in Prostate Cancer Sept 2016]</ref>
The 1245C allele encodes for a missense and hyperactive enzyme that increases extragonadal androgen synthesis and is associated with poorer outcomes after androgen deprivation therapy in [[prostate cancer]].<ref name="pmid27979506">{{cite journal | vauthors = Taneja SS | title = Re: HSD3B1 and Resistance to Androgen-Deprivation Therapy in Prostate Cancer: A Retrospective, Multicohort Study | journal = The Journal of Urology | volume = 197 | issue = 1 | pages = 150 | date = January 2017 | pmid = 27979506 | doi = 10.1016/j.juro.2016.10.045 }}</ref><ref>{{cite journal |last1=Hearn |first1=Jason |title=HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study |journal=Lancet Oncology |date=October 2016 |volume=17 |issue=10 |doi=10.1016/S1470-2045(16)30227-3 |pmid=27575027 |url=https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(16)30227-3/abstract?code=lancet-site}}</ref>


==References==
== References ==
{{reflist}}
{{reflist}}
<ref>{{cite journal |last1=Chang |first1=Kai-Hsiung |title=A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer |journal=Cell |date=August 2013 |volume=154 |issue=5 |page=1074-1084 |doi=10.1016/j.cell.2013.07.029 |pmid=23993097 |url=https://www.cell.com/cell/abstract/S0092-8674(13)00900-8}}</ref>


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dumont M, Luu-The V, Dupont E, Pelletier G, Labrie F | title = Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin | journal = The Journal of Investigative Dermatology | volume = 99 | issue = 4 | pages = 415–21 | date = October 1992 | pmid = 1401999 | doi = 10.1111/1523-1747.ep12616131 }}
| citations =
* {{cite journal | vauthors = Russell AJ, Gaffney D, Gardiner MT, Nickson DA, Sutcliffe RG | title = Synonymous polymorphism in the coding sequence of human 3-beta hydroxysteroid-5-ene dehydrogenase (HSD) | journal = Nucleic Acids Research | volume = 19 | issue = 5 | pages = 1172 | date = March 1991 | pmid = 1673569 | pmc = 333834 | doi = 10.1093/nar/19.5.1172-a }}
*{{cite journal   |vauthors=Dumont M, Luu-The V, Dupont E, etal |title=Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin. |journal=J. Invest. Dermatol. |volume=99 |issue= 4 |pages= 415–21 |year= 1992 |pmid= 1401999 |doi=10.1111/1523-1747.ep12616131 }}
* {{cite journal | vauthors = Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guérin S, Leblanc G, Labrie F | title = Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells | journal = The Journal of Biological Chemistry | volume = 267 | issue = 5 | pages = 3551 | date = February 1992 | pmid = 1737804 | doi =  }}
*{{cite journal   |vauthors=Russell AJ, Gaffney D, Gardiner MT, etal |title=Synonymous polymorphism in the coding sequence of human 3-beta hydroxysteroid-5-ene dehydrogenase (HSD). |journal=Nucleic Acids Res. |volume=19 |issue= 5 |pages= 1172 |year= 1991 |pmid= 1673569 |doi=10.1093/nar/19.5.1172-a | pmc=333834  }}
* {{cite journal | vauthors = Nickson DA, McBride MW, Zeinali S, Hawes CS, Petropoulos A, Mueller UW, Sutcliffe RG | title = Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase | journal = Journal of Reproduction and Fertility | volume = 93 | issue = 1 | pages = 149–56 | date = September 1991 | pmid = 1920284 | doi = 10.1530/jrf.0.0930149 }}
*{{cite journal   |vauthors=Lachance Y, Luu-The V, Labrie C, etal |title=Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3551 |year= 1992 |pmid= 1737804 |doi=  }}
* {{cite journal | vauthors = Rhéaume E, Lachance Y, Zhao HF, Breton N, Dumont M, de Launoit Y, Trudel C, Luu-The V, Simard J, Labrie F | title = Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads | journal = Molecular Endocrinology | volume = 5 | issue = 8 | pages = 1147–57 | date = August 1991 | pmid = 1944309 | doi = 10.1210/mend-5-8-1147 }}
*{{cite journal   |vauthors=Nickson DA, McBride MW, Zeinali S, etal |title=Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase. |journal=J. Reprod. Fertil. |volume=93 |issue= 1 |pages= 149–56 |year= 1991 |pmid= 1920284 |doi=10.1530/jrf.0.0930149 }}
* {{cite journal | vauthors = Morrison N, Nickson DA, McBride MW, Mueller UW, Boyd E, Sutcliffe RG | title = Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation | journal = Human Genetics | volume = 87 | issue = 2 | pages = 223–5 | date = June 1991 | pmid = 2066113 | doi = 10.1007/BF00204189 }}
*{{cite journal   |vauthors=Rhéaume E, Lachance Y, Zhao HF, etal |title=Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads. |journal=Mol. Endocrinol. |volume=5 |issue= 8 |pages= 1147–57 |year= 1991 |pmid= 1944309 |doi=10.1210/mend-5-8-1147 }}
* {{cite journal | vauthors = Lorence MC, Corbin CJ, Kamimura N, Mahendroo MS, Mason JI | title = Structural analysis of the gene encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase | journal = Molecular Endocrinology | volume = 4 | issue = 12 | pages = 1850–5 | date = December 1990 | pmid = 2082186 | doi = 10.1210/mend-4-12-1850 }}
*{{cite journal   |vauthors=Morrison N, Nickson DA, McBride MW, etal |title=Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation. |journal=Hum. Genet. |volume=87 |issue= 2 |pages= 223–5 |year= 1991 |pmid= 2066113 |doi=10.1007/BF00204189 }}
* {{cite journal | vauthors = Lorence MC, Murry BA, Trant JM, Mason JI | title = Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids | journal = Endocrinology | volume = 126 | issue = 5 | pages = 2493–8 | date = May 1990 | pmid = 2139411 | doi = 10.1210/endo-126-5-2493 }}
*{{cite journal   |vauthors=Lorence MC, Corbin CJ, Kamimura N, etal |title=Structural analysis of the gene encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase. |journal=Mol. Endocrinol. |volume=4 |issue= 12 |pages= 1850–5 |year= 1991 |pmid= 2082186 |doi=10.1210/mend-4-12-1850 }}
* {{cite journal | vauthors = Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guérin S, Leblanc G, Labrie F | title = Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells | journal = The Journal of Biological Chemistry | volume = 265 | issue = 33 | pages = 20469–75 | date = November 1990 | pmid = 2243100 | doi =  }}
*{{cite journal |vauthors=Lorence MC, Murry BA, Trant JM, Mason JI |title=Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids. |journal=Endocrinology |volume=126 |issue= 5 |pages= 2493–8 |year= 1990 |pmid= 2139411 |doi=10.1210/endo-126-5-2493 }}
* {{cite journal | vauthors = Luu The V, Lachance Y, Labrie C, Leblanc G, Thomas JL, Strickler RC, Labrie F | title = Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase | journal = Molecular Endocrinology | volume = 3 | issue = 8 | pages = 1310–2 | date = August 1989 | pmid = 2779585 | doi = 10.1210/mend-3-8-1310 }}
*{{cite journal   |vauthors=Lachance Y, Luu-The V, Labrie C, etal |title=Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. |journal=J. Biol. Chem. |volume=265 |issue= 33 |pages= 20469–75 |year= 1990 |pmid= 2243100 |doi=  }}
* {{cite journal | vauthors = Thomas JL, Frieden C, Nash WE, Strickler RC | title = An NADH-induced conformational change that mediates the sequential 3 beta-hydroxysteroid dehydrogenase/isomerase activities is supported by affinity labeling and the time-dependent activation of isomerase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 36 | pages = 21003–8 | date = September 1995 | pmid = 7673125 | doi = 10.1074/jbc.270.36.21003 }}
*{{cite journal   |vauthors=Luu The V, Lachance Y, Labrie C, etal |title=Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase. |journal=Mol. Endocrinol. |volume=3 |issue= 8 |pages= 1310–2 |year= 1989 |pmid= 2779585 |doi=10.1210/mend-3-8-1310 }}
* {{cite journal | vauthors = Alvarez CI, Genti-Raimondi S, Patrito LC, Flury A | title = Topography of human placental 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in microsomal membrane. A study using limited proteolysis and immunoblotting | journal = Biochimica et Biophysica Acta | volume = 1207 | issue = 1 | pages = 102–8 | date = July 1994 | pmid = 8043598 | doi = 10.1016/0167-4838(94)90057-4 }}
*{{cite journal |vauthors=Thomas JL, Frieden C, Nash WE, Strickler RC |title=An NADH-induced conformational change that mediates the sequential 3 beta-hydroxysteroid dehydrogenase/isomerase activities is supported by affinity labeling and the time-dependent activation of isomerase. |journal=J. Biol. Chem. |volume=270 |issue= 36 |pages= 21003–8 |year= 1995 |pmid= 7673125 |doi=10.1074/jbc.270.36.21003 }}
* {{cite journal | vauthors = Cherradi N, Defaye G, Chambaz EM | title = Dual subcellular localization of the 3 beta-hydroxysteroid dehydrogenase isomerase: characterization of the mitochondrial enzyme in the bovine adrenal cortex | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 46 | issue = 6 | pages = 773–9 | date = December 1993 | pmid = 8274411 | doi = 10.1016/0960-0760(93)90318-Q }}
*{{cite journal |vauthors=Alvarez CI, Genti-Raimondi S, Patrito LC, Flury A |title=Topography of human placental 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in microsomal membrane. A study using limited proteolysis and immunoblotting. |journal=Biochim. Biophys. Acta |volume=1207 |issue= 1 |pages= 102–8 |year= 1994 |pmid= 8043598 |doi= 10.1016/0167-4838(94)90057-4}}
* {{cite journal | vauthors = Hatakeyama H, Miyamori I, Takeda Y, Yamamoto H, Mabuchi H | title = The expression of steroidogenic enzyme genes in human vascular cells | journal = Biochemistry and Molecular Biology International | volume = 40 | issue = 3 | pages = 639–45 | date = October 1996 | pmid = 8908375 | doi = 10.1080/15216549600201233 }}
*{{cite journal |vauthors=Cherradi N, Defaye G, Chambaz EM |title=Dual subcellular localization of the 3 beta-hydroxysteroid dehydrogenase isomerase: characterization of the mitochondrial enzyme in the bovine adrenal cortex. |journal=J. Steroid Biochem. Mol. Biol. |volume=46 |issue= 6 |pages= 773–9 |year= 1994 |pmid= 8274411 |doi=10.1016/0960-0760(93)90318-Q }}
* {{cite journal | vauthors = El-Alfy M, Luu-The V, Huang XF, Berger L, Labrie F, Pelletier G | title = Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry | journal = Endocrinology | volume = 140 | issue = 3 | pages = 1481–91 | date = March 1999 | pmid = 10067877 | doi = 10.1210/en.140.3.1481 }}
*{{cite journal   |vauthors=Hatakeyama H, Miyamori I, Takeda Y, etal |title=The expression of steroidogenic enzyme genes in human vascular cells. |journal=Biochem. Mol. Biol. Int. |volume=40 |issue= 3 |pages= 639–45 |year= 1997 |pmid= 8908375 |doi= 10.1080/15216549600201233}}
* {{cite journal | vauthors = Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES | title = Characterization of single-nucleotide polymorphisms in coding regions of human genes | journal = Nature Genetics | volume = 22 | issue = 3 | pages = 231–8 | date = July 1999 | pmid = 10391209 | doi = 10.1038/10290 }}
*{{cite journal   |vauthors=El-Alfy M, Luu-The V, Huang XF, etal |title=Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. |journal=Endocrinology |volume=140 |issue= 3 |pages= 1481–91 |year= 1999 |pmid= 10067877 |doi=10.1210/en.140.3.1481 }}
* {{cite journal | vauthors = Bonenfant M, Provost PR, Drolet R, Tremblay Y | title = Localization of type 1 17beta-hydroxysteroid dehydrogenase mRNA and protein in syncytiotrophoblasts and invasive cytotrophoblasts in the human term villi | journal = The Journal of Endocrinology | volume = 165 | issue = 2 | pages = 217–22 | date = May 2000 | pmid = 10810285 | doi = 10.1677/joe.0.1650217 }}
*{{cite journal   |vauthors=Cargill M, Altshuler D, Ireland J, etal |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231–8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
* {{cite journal | vauthors = Pelletier G, Luu-The V, El-Alfy M, Li S, Labrie F | title = Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland | journal = Journal of Molecular Endocrinology | volume = 26 | issue = 1 | pages = 11–9 | date = February 2001 | pmid = 11174850 | doi = 10.1677/jme.0.0260011 }}
*{{cite journal |vauthors=Bonenfant M, Provost PR, Drolet R, Tremblay Y |title=Localization of type 1 17beta-hydroxysteroid dehydrogenase mRNA and protein in syncytiotrophoblasts and invasive cytotrophoblasts in the human term villi. |journal=J. Endocrinol. |volume=165 |issue= 2 |pages= 217–22 |year= 2000 |pmid= 10810285 |doi=10.1677/joe.0.1650217 }}
* {{cite journal | vauthors = Pang S, Wang W, Rich B, David R, Chang YT, Carbunaru G, Myers SE, Howie AF, Smillie KJ, Mason JI | title = A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 6 | pages = 2556–63 | date = June 2002 | pmid = 12050213 | doi = 10.1210/jc.87.6.2556 }}
*{{cite journal   |vauthors=Pelletier G, Luu-The V, El-Alfy M, etal |title=Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland. |journal=J. Mol. Endocrinol. |volume=26 |issue= 1 |pages= 11–9 |year= 2001 |pmid= 11174850 |doi=10.1677/jme.0.0260011 }}
* {{cite journal | vauthors = Rosmond R, Chagnon M, Bouchard C, Björntorp P | title = Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 629–32 | date = April 2002 | pmid = 12054649 | doi = 10.1016/S0006-291X(02)00234-6 }}
*{{cite journal   |vauthors=Pang S, Wang W, Rich B, etal |title=A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2556–63 |year= 2002 |pmid= 12050213 |doi=10.1210/jc.87.6.2556 }}
*{{cite journal |vauthors=Rosmond R, Chagnon M, Bouchard C, Björntorp P |title=Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 629–32 |year= 2002 |pmid= 12054649 |doi= 10.1016/S0006-291X(02)00234-6 }}
}}
{{refend}}
{{refend}}


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{{gene-1-stub}}

Latest revision as of 04:39, 2 January 2019

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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UniProt

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HSD3B1 is a human gene that encodes for a 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1.[1] While it can carry out the same function as HSD3B2, it localizes primarily to different tissues, such as the placenta and nonsteroidogenic tissues. Its requirement for the production of progesterone by the placenta, which has a vital role in pregnancy, may be one reason why no disease based on mutations in this gene has been identified to date.

Clinical significance

The 1245C allele encodes for a missense and hyperactive enzyme that increases extragonadal androgen synthesis and is associated with poorer outcomes after androgen deprivation therapy in prostate cancer.[2][3]

References

  1. ↑ "Entrez Gene: HSD3B1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1".
  2. ↑ Taneja SS (January 2017). "Re: HSD3B1 and Resistance to Androgen-Deprivation Therapy in Prostate Cancer: A Retrospective, Multicohort Study". The Journal of Urology. 197 (1): 150. doi:10.1016/j.juro.2016.10.045. PMID 27979506.
  3. ↑ Hearn, Jason (October 2016). "HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study". Lancet Oncology. 17 (10). doi:10.1016/S1470-2045(16)30227-3. PMID 27575027.

[1]

Further reading

  • Dumont M, Luu-The V, Dupont E, Pelletier G, Labrie F (October 1992). "Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin". The Journal of Investigative Dermatology. 99 (4): 415–21. doi:10.1111/1523-1747.ep12616131. PMID 1401999.
  • Russell AJ, Gaffney D, Gardiner MT, Nickson DA, Sutcliffe RG (March 1991). "Synonymous polymorphism in the coding sequence of human 3-beta hydroxysteroid-5-ene dehydrogenase (HSD)". Nucleic Acids Research. 19 (5): 1172. doi:10.1093/nar/19.5.1172-a. PMC 333834. PMID 1673569.
  • Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guérin S, Leblanc G, Labrie F (February 1992). "Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells". The Journal of Biological Chemistry. 267 (5): 3551. PMID 1737804.
  • Nickson DA, McBride MW, Zeinali S, Hawes CS, Petropoulos A, Mueller UW, Sutcliffe RG (September 1991). "Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase". Journal of Reproduction and Fertility. 93 (1): 149–56. doi:10.1530/jrf.0.0930149. PMID 1920284.
  • Rhéaume E, Lachance Y, Zhao HF, Breton N, Dumont M, de Launoit Y, Trudel C, Luu-The V, Simard J, Labrie F (August 1991). "Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads". Molecular Endocrinology. 5 (8): 1147–57. doi:10.1210/mend-5-8-1147. PMID 1944309.
  • Morrison N, Nickson DA, McBride MW, Mueller UW, Boyd E, Sutcliffe RG (June 1991). "Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation". Human Genetics. 87 (2): 223–5. doi:10.1007/BF00204189. PMID 2066113.
  • Lorence MC, Corbin CJ, Kamimura N, Mahendroo MS, Mason JI (December 1990). "Structural analysis of the gene encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase". Molecular Endocrinology. 4 (12): 1850–5. doi:10.1210/mend-4-12-1850. PMID 2082186.
  • Lorence MC, Murry BA, Trant JM, Mason JI (May 1990). "Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids". Endocrinology. 126 (5): 2493–8. doi:10.1210/endo-126-5-2493. PMID 2139411.
  • Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guérin S, Leblanc G, Labrie F (November 1990). "Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells". The Journal of Biological Chemistry. 265 (33): 20469–75. PMID 2243100.
  • Luu The V, Lachance Y, Labrie C, Leblanc G, Thomas JL, Strickler RC, Labrie F (August 1989). "Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase". Molecular Endocrinology. 3 (8): 1310–2. doi:10.1210/mend-3-8-1310. PMID 2779585.
  • Thomas JL, Frieden C, Nash WE, Strickler RC (September 1995). "An NADH-induced conformational change that mediates the sequential 3 beta-hydroxysteroid dehydrogenase/isomerase activities is supported by affinity labeling and the time-dependent activation of isomerase". The Journal of Biological Chemistry. 270 (36): 21003–8. doi:10.1074/jbc.270.36.21003. PMID 7673125.
  • Alvarez CI, Genti-Raimondi S, Patrito LC, Flury A (July 1994). "Topography of human placental 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in microsomal membrane. A study using limited proteolysis and immunoblotting". Biochimica et Biophysica Acta. 1207 (1): 102–8. doi:10.1016/0167-4838(94)90057-4. PMID 8043598.
  • Cherradi N, Defaye G, Chambaz EM (December 1993). "Dual subcellular localization of the 3 beta-hydroxysteroid dehydrogenase isomerase: characterization of the mitochondrial enzyme in the bovine adrenal cortex". The Journal of Steroid Biochemistry and Molecular Biology. 46 (6): 773–9. doi:10.1016/0960-0760(93)90318-Q. PMID 8274411.
  • Hatakeyama H, Miyamori I, Takeda Y, Yamamoto H, Mabuchi H (October 1996). "The expression of steroidogenic enzyme genes in human vascular cells". Biochemistry and Molecular Biology International. 40 (3): 639–45. doi:10.1080/15216549600201233. PMID 8908375.
  • El-Alfy M, Luu-The V, Huang XF, Berger L, Labrie F, Pelletier G (March 1999). "Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry". Endocrinology. 140 (3): 1481–91. doi:10.1210/en.140.3.1481. PMID 10067877.
  • Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES (July 1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nature Genetics. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.
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  1. ↑ Chang, Kai-Hsiung (August 2013). "A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer". Cell. 154 (5): 1074-1084. doi:10.1016/j.cell.2013.07.029. PMID 23993097.
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