SOAT1: Difference between revisions

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
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Latest revision as of 10:13, 2 March 2018

Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, also known as SOAT1, is an enzyme that in humans is encoded by the SOAT1 gene.^[1]

Function

Acyl-coenzyme A:cholesterol acyltransferase (EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).^[1]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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<imagemap> Image:StatinPathway_WP430.png

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Statin Pathway edit

↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

↑ ^1.0 ^1.1 "Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1".

@@ Line 1: / Line 1: @@
+{{Distinguish|Acetyl-Coenzyme A acetyltransferase}}
+{{Infobox_gene}}
+'''Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1''', also known as '''SOAT1''', is an [[enzyme]] that in humans is encoded by the ''SOAT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6646| accessdate = }}</ref>
+== Function ==
+Acyl-coenzyme A:cholesterol acyltransferase ({{EC number|2.3.1.26}}) is an intracellular protein located in the [[endoplasmic reticulum]] that forms [[cholesteryl ester|cholesterol ester]]s from [[cholesterol]]. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).<ref name="entrez"/>
+==Interactive pathway map==
+{{StatinPathway_WP430|highlight=SOAT1}}
+== See also ==
+* [[Acyl-CoA:cholesterol acyltransferase]]
+== References ==
+{{reflist}}
+== Further reading ==
+{{refbegin | 2}}
+{{PBB_ng Further_readi
+| citations =
+*{{cite journal   |vauthors=Chang TY, Chang CC, Lin S, etal |title=Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. |journal=Curr. Opin. Lipidol. |volume=12 |issue= 3 |pages= 289–96 |year= 2001 |pmid= 11353332 |doi=10.1097/00041433-200106000-00008  }}
+*{{cite journal   |vauthors=Chang CC, Noll WW, Nutile-McMenemy N, etal |title=Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 1 |pages= 71–4 |year= 1994 |pmid= 8197480 |doi=10.1007/BF02257489  }}
+*{{cite journal  | vauthors=Chang CC, Huh HY, Cadigan KM, Chang TY |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20747–55 |year= 1993 |pmid= 8407899 |doi=  10.1074/jbc.273.52.35132}}
+*{{cite journal   |vauthors=Chang CCY, Lee CYG, Chang ET, Cruz JC, Levesque M, Chang TY |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35132–41 |year= 1998 |pmid= 8407899 |doi=  10.1074/jbc.273.52.35132 |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells}}
+*{{cite journal   |vauthors=Oelkers P, Behari A, Cromley D, etal |title=Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26765–71 |year= 1998 |pmid= 9756920 |doi=10.1074/jbc.273.41.26765  }}
+*{{cite journal   |vauthors=Li BL, Li XL, Duan ZJ, etal |title=Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11060–71 |year= 1999 |pmid= 10196189 |doi=10.1074/jbc.274.16.11060  }}
+*{{cite journal   |vauthors=Lin S, Cheng D, Liu MS, etal |title=Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23276–85 |year= 1999 |pmid= 10438503 |doi=10.1074/jbc.274.33.23276  }}
+*{{cite journal   |vauthors=Sakashita N, Miyazaki A, Takeya M, etal |title=Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues. |journal=Am. J. Pathol. |volume=156 |issue= 1 |pages= 227–36 |year= 2000 |pmid= 10623671 |doi=  10.1016/S0002-9440(10)64723-2| pmc=1868616  }}
+*{{cite journal  | vauthors=Guo Z, Cromley D, Billheimer JT, Sturley SL |title=Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences. |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1282–91 |year= 2001 |pmid= 11483630 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Zhang Y, Yu C, Liu J, etal |title=Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11642–7 |year= 2003 |pmid= 12533546 |doi= 10.1074/jbc.M211559200 }}
+*{{cite journal   |vauthors=Wollmer MA, Streffer JR, Tsolaki M, etal |title=Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. |journal=Mol. Psychiatry |volume=8 |issue= 6 |pages= 635–8 |year= 2004 |pmid= 12851640 |doi= 10.1038/sj.mp.4001296 }}
+*{{cite journal   |vauthors=Smith JL, Rangaraj K, Simpson R, etal |title=Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR. |journal=J. Lipid Res. |volume=45 |issue= 4 |pages= 686–96 |year= 2004 |pmid= 14729857 |doi= 10.1194/jlr.M300365-JLR200 }}
+*{{cite journal   |vauthors=Hori M, Miyazaki A, Tamagawa H, etal |title=Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 2 |pages= 501–5 |year= 2004 |pmid= 15219857 |doi= 10.1016/j.bbrc.2004.05.190 }}
+*{{cite journal   |vauthors=Yang L, Chen J, Chang CC, etal |title=A stable upstream stem-loop structure enhances selection of the first 5'-ORF-AUG as a main start codon for translation initiation of human ACAT1 mRNA. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 4 |pages= 259–68 |year= 2004 |pmid= 15253151 |doi=10.1093/abbs/36.4.259  }}
+*{{cite journal   |vauthors=Liang JJ, Oelkers P, Guo C, etal |title=Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44938–44 |year= 2004 |pmid= 15308631 |doi= 10.1074/jbc.M408507200 }}
+*{{cite journal   |vauthors=Yang L, Lee O, Chen J, etal |title=Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 46253–62 |year= 2004 |pmid= 15319423 |doi= 10.1074/jbc.M408155200 }}
+*{{cite journal   |vauthors=Yang L, Yang JB, Chen J, etal |title=Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. |journal=Cell Res. |volume=14 |issue= 4 |pages= 315–23 |year= 2005 |pmid= 15353128 |doi= 10.1038/sj.cr.7290231 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+*{{cite journal   |vauthors=Bertram L, Hsiao M, Mullin K, etal |title=ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. |journal=Mol. Psychiatry |volume=10 |issue= 6 |pages= 522–4 |year= 2005 |pmid= 15768051 |doi= 10.1038/sj.mp.4001646 }}
+}}
+{{refend}}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
 {{PBB_Controls
@@ Line 4: / Line 48: @@
 | require_manual_inspection = no
 | update_protein_box = yes
-| update_summary = yes
+| update_summary = no
 | update_citations = yes
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
- | HGNCid = 11177
- | Symbol = SOAT1
- | AltSymbols =; ACAT1; ACAT; ACACT; RP11-215I23.2; SOAT; STAT
- | OMIM = 102642
- | ECnumber =
- | Homologene = 2333
- | MGIid = 104665
- | GeneAtlas_image1 = PBB_GE_SOAT1_221561_at_tn.png
- | Function = {{GNF_GO|id=GO:0004772 |text = sterol O-acyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6646
-    | Hs_Ensembl = ENSG00000057252
-    | Hs_RefseqProtein = NP_003092
-    | Hs_RefseqmRNA = NM_003101
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 177529560
-    | Hs_GenLoc_end = 177594438
-    | Hs_Uniprot = P35610
-    | Mm_EntrezGene = 20652
-    | Mm_Ensembl = ENSMUSG00000026600
-    | Mm_RefseqmRNA = NM_009230
-    | Mm_RefseqProtein = NP_033256
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 158265149
-    | Mm_GenLoc_end = 158310920
-    | Mm_Uniprot = Q06EZ3
-  }}
-}}
-'''Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1''', also known as '''SOAT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6646| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6646| accessdate = }}</ref>
-}}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Chang TY, Chang CC, Lin S, ''et al.'' |title=Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. |journal=Curr. Opin. Lipidol. |volume=12 |issue= 3 |pages= 289-96 |year= 2001 |pmid= 11353332 |doi=  }}
-*{{cite journal  | author=Chang CC, Noll WW, Nutile-McMenemy N, ''et al.'' |title=Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 1 |pages= 71-4 |year= 1994 |pmid= 8197480 |doi=  }}
-*{{cite journal  | author=Chang CC, Huh HY, Cadigan KM, Chang TY |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20747-55 |year= 1993 |pmid= 8407899 |doi=  }}
-*{{cite journal  | author=Oelkers P, Behari A, Cromley D, ''et al.'' |title=Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26765-71 |year= 1998 |pmid= 9756920 |doi=  }}
-*{{cite journal  | author=Li BL, Li XL, Duan ZJ, ''et al.'' |title=Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11060-71 |year= 1999 |pmid= 10196189 |doi=  }}
-*{{cite journal  | author=Lin S, Cheng D, Liu MS, ''et al.'' |title=Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23276-85 |year= 1999 |pmid= 10438503 |doi=  }}
-*{{cite journal  | author=Sakashita N, Miyazaki A, Takeya M, ''et al.'' |title=Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues. |journal=Am. J. Pathol. |volume=156 |issue= 1 |pages= 227-36 |year= 2000 |pmid= 10623671 |doi=  }}
-*{{cite journal  | author=Guo Z, Cromley D, Billheimer JT, Sturley SL |title=Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences. |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1282-91 |year= 2001 |pmid= 11483630 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Zhang Y, Yu C, Liu J, ''et al.'' |title=Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11642-7 |year= 2003 |pmid= 12533546 |doi= 10.1074/jbc.M211559200 }}
-*{{cite journal  | author=Wollmer MA, Streffer JR, Tsolaki M, ''et al.'' |title=Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. |journal=Mol. Psychiatry |volume=8 |issue= 6 |pages= 635-8 |year= 2004 |pmid= 12851640 |doi= 10.1038/sj.mp.4001296 }}
-*{{cite journal  | author=Smith JL, Rangaraj K, Simpson R, ''et al.'' |title=Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR. |journal=J. Lipid Res. |volume=45 |issue= 4 |pages= 686-96 |year= 2004 |pmid= 14729857 |doi= 10.1194/jlr.M300365-JLR200 }}
-*{{cite journal  | author=Hori M, Miyazaki A, Tamagawa H, ''et al.'' |title=Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 2 |pages= 501-5 |year= 2004 |pmid= 15219857 |doi= 10.1016/j.bbrc.2004.05.190 }}
-*{{cite journal  | author=Yang L, Chen J, Chang CC, ''et al.'' |title=A stable upstream stem-loop structure enhances selection of the first 5'-ORF-AUG as a main start codon for translation initiation of human ACAT1 mRNA. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 4 |pages= 259-68 |year= 2004 |pmid= 15253151 |doi=  }}
-*{{cite journal  | author=Liang JJ, Oelkers P, Guo C, ''et al.'' |title=Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44938-44 |year= 2004 |pmid= 15308631 |doi= 10.1074/jbc.M408507200 }}
-*{{cite journal  | author=Yang L, Lee O, Chen J, ''et al.'' |title=Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 46253-62 |year= 2004 |pmid= 15319423 |doi= 10.1074/jbc.M408155200 }}
-*{{cite journal  | author=Yang L, Yang JB, Chen J, ''et al.'' |title=Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. |journal=Cell Res. |volume=14 |issue= 4 |pages= 315-23 |year= 2005 |pmid= 15353128 |doi= 10.1038/sj.cr.7290231 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Bertram L, Hsiao M, Mullin K, ''et al.'' |title=ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. |journal=Mol. Psychiatry |volume=10 |issue= 6 |pages= 522-4 |year= 2005 |pmid= 15768051 |doi= 10.1038/sj.mp.4001646 }}
-}}
-{{refend}}
-{{protein-stub}}
+{{gene-1-stub}}
-{{WikiDoc Sources}}

SOAT1: Difference between revisions

Latest revision as of 10:13, 2 March 2018

Contents

Function

Interactive pathway map

See also

References

Further reading

Navigation menu