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{{Infobox_gene}}
{{PBB_Controls
'''Kinesin-like protein KIF2C''' is a [[protein]] that in humans is encoded by the ''KIF2C'' [[gene]].<ref name="pmid9434124">{{cite journal |vauthors=Kim IG, Jun DY, Sohn U, Kim YH | title = Cloning and expression of human mitotic centromere-associated kinesin gene | journal = Biochim Biophys Acta | volume = 1359 | issue = 3 | pages = 181–6 |date=Feb 1998 | pmid = 9434124 | pmc =  | doi = 10.1016/s0167-4889(97)00103-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF2C kinesin family member 2C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11004| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KIF2C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1v8j.
| PDB = {{PDB2|1v8j}}, {{PDB2|1v8k}}, {{PDB2|2heh}}
| Name = Kinesin family member 2C
| HGNCid = 6393
| Symbol = KIF2C
| AltSymbols =; KNSL6; MCAK
| OMIM = 604538
| ECnumber =
| Homologene = 21355
| MGIid = 1921054
| GeneAtlas_image1 = PBB_GE_KIF2C_211519_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_KIF2C_209408_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0019237 |text = centromeric DNA binding}}
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005871 |text = kinesin complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030951 |text = establishment and/or maintenance of microtubule cytoskeleton polarity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11004
    | Hs_Ensembl = ENSG00000142945
    | Hs_RefseqProtein = NP_006836
    | Hs_RefseqmRNA = NM_006845
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 44978079
    | Hs_GenLoc_end = 45006026
    | Hs_Uniprot = Q99661
    | Mm_EntrezGene = 73804
    | Mm_Ensembl = ENSMUSG00000028678
    | Mm_RefseqmRNA = XM_986203
    | Mm_RefseqProtein = XP_991297
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 116657593
    | Mm_GenLoc_end = 116680496
    | Mm_Uniprot = Q3TTL2
  }}
}}
'''Kinesin family member 2C''', also known as '''KIF2C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF2C kinesin family member 2C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11004| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.<ref name="entrez">{{cite web | title = Entrez Gene: KIF2C kinesin family member 2C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11004| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of [[kinesin]]-like protein family. Most proteins of this family are [[microtubule]]-dependent [[motor protein|molecular motors]] that transport [[organelle]]s within cells and move [[chromosome]]s during [[cell division]]. This protein acts to regulate microtubule dynamics in cells and is important for [[anaphase]] [[chromosome segregation]] and may be required to coordinate the onset of sister [[centromere]] separation.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Miki H, Setou M, Kaneshiro K, Hirokawa N |title=All kinesin superfamily protein, KIF, genes in mouse and human. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7004-11 |year= 2001 |pmid= 11416179 |doi= 10.1073/pnas.111145398 }}
*{{cite journal  |vauthors=Miki H, Setou M, Kaneshiro K, Hirokawa N |title=All kinesin superfamily protein, KIF, genes in mouse and human |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7004–11 |year= 2001 |pmid= 11416179 |doi= 10.1073/pnas.111145398  | pmc=34614 }}
*{{cite journal | author=Kim IG, Jun DY, Sohn U, Kim YH |title=Cloning and expression of human mitotic centromere-associated kinesin gene. |journal=Biochim. Biophys. Acta |volume=1359 |issue= 3 |pages= 181-6 |year= 1998 |pmid= 9434124 |doi= }}
*{{cite journal  |vauthors=Maney T, Hunter AW, Wagenbach M, Wordeman L |title=Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation |journal=J. Cell Biol. |volume=142 |issue= 3 |pages= 787–801 |year= 1998 |pmid= 9700166 |doi=10.1083/jcb.142.3.787  | pmc=2148171 }}
*{{cite journal  | author=Maney T, Hunter AW, Wagenbach M, Wordeman L |title=Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. |journal=J. Cell Biol. |volume=142 |issue= 3 |pages= 787-801 |year= 1998 |pmid= 9700166 |doi=  }}
*{{cite journal  |vauthors=Wordeman L, Wagenbach M, Maney T |title=Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK) |journal=Cell Biol. Int. |volume=23 |issue= 4 |pages= 275–86 |year= 2000 |pmid= 10600236 |doi= 10.1006/cbir.1999.0359 }}
*{{cite journal  | author=Wordeman L, Wagenbach M, Maney T |title=Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK). |journal=Cell Biol. Int. |volume=23 |issue= 4 |pages= 275-86 |year= 2000 |pmid= 10600236 |doi= 10.1006/cbir.1999.0359 }}
*{{cite journal   |vauthors=Sugata N, Li S, Earnshaw WC, etal |title=Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes |journal=Hum. Mol. Genet. |volume=9 |issue= 19 |pages= 2919–26 |year= 2001 |pmid= 11092768 |doi=10.1093/hmg/9.19.2919 }}
*{{cite journal | author=Sugata N, Li S, Earnshaw WC, ''et al.'' |title=Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. |journal=Hum. Mol. Genet. |volume=9 |issue= 19 |pages= 2919-26 |year= 2001 |pmid= 11092768 |doi=  }}
*{{cite journal  |vauthors=Maney T, Wagenbach M, Wordeman L |title=Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34753–8 |year= 2001 |pmid= 11466324 |doi= 10.1074/jbc.M106626200 }}
*{{cite journal  | author=Maney T, Wagenbach M, Wordeman L |title=Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34753-8 |year= 2001 |pmid= 11466324 |doi= 10.1074/jbc.M106626200 }}
*{{cite journal   |vauthors=Cheng LJ, Zhou ZM, Li JM, etal |title=Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis |journal=Life Sci. |volume=71 |issue= 23 |pages= 2741–57 |year= 2002 |pmid= 12383881 |doi=10.1016/S0024-3205(02)02079-9 }}
*{{cite journal | author=Cheng LJ, Zhou ZM, Li JM, ''et al.'' |title=Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis. |journal=Life Sci. |volume=71 |issue= 23 |pages= 2741-57 |year= 2002 |pmid= 12383881 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Cassimeris L, Morabito J |title=TOGp, the Human Homolog of XMAP215/Dis1, Is Required for Centrosome Integrity, Spindle Pole Organization, and Bipolar Spindle Assembly |journal=Mol. Biol. Cell |volume=15 |issue= 4 |pages= 1580–90 |year= 2004 |pmid= 14718566 |doi= 10.1091/mbc.E03-07-0544 | pmc=379257 }}
*{{cite journal  | author=Cassimeris L, Morabito J |title=TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. |journal=Mol. Biol. Cell |volume=15 |issue= 4 |pages= 1580-90 |year= 2004 |pmid= 14718566 |doi= 10.1091/mbc.E03-07-0544 }}
*{{cite journal  |vauthors=Ganem NJ, Compton DA |title=The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK |journal=J. Cell Biol. |volume=166 |issue= 4 |pages= 473–8 |year= 2004 |pmid= 15302853 |doi= 10.1083/jcb.200404012 | pmc=2172212 }}
*{{cite journal  | author=Ganem NJ, Compton DA |title=The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. |journal=J. Cell Biol. |volume=166 |issue= 4 |pages= 473-8 |year= 2004 |pmid= 15302853 |doi= 10.1083/jcb.200404012 }}
*{{cite journal   |vauthors=Newton CN, Wagenbach M, Ovechkina Y, etal |title=MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro |journal=FEBS Lett. |volume=572 |issue= 1–3 |pages= 80–4 |year= 2004 |pmid= 15304328 |doi= 10.1016/j.febslet.2004.06.093 }}
*{{cite journal | author=Newton CN, Wagenbach M, Ovechkina Y, ''et al.'' |title=MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 80-4 |year= 2004 |pmid= 15304328 |doi= 10.1016/j.febslet.2004.06.093 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Moore AT, Rankin KE, von Dassow G, etal |title=MCAK associates with the tips of polymerizing microtubules |journal=J. Cell Biol. |volume=169 |issue= 3 |pages= 391–7 |year= 2005 |pmid= 15883193 |doi= 10.1083/jcb.200411089 | pmc=2171944 }}
*{{cite journal | author=Moore AT, Rankin KE, von Dassow G, ''et al.'' |title=MCAK associates with the tips of polymerizing microtubules. |journal=J. Cell Biol. |volume=169 |issue= 3 |pages= 391-7 |year= 2005 |pmid= 15883193 |doi= 10.1083/jcb.200411089 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Ganem NJ, Upton K, Compton DA |title=Efficient mitosis in human cells lacking poleward microtubule flux |journal=Curr. Biol. |volume=15 |issue= 20 |pages= 1827–32 |year= 2006 |pmid= 16243029 |doi= 10.1016/j.cub.2005.08.065 }}
*{{cite journal  | author=Ganem NJ, Upton K, Compton DA |title=Efficient mitosis in human cells lacking poleward microtubule flux. |journal=Curr. Biol. |volume=15 |issue= 20 |pages= 1827-32 |year= 2006 |pmid= 16243029 |doi= 10.1016/j.cub.2005.08.065 }}
*{{cite journal   |vauthors=Helenius J, Brouhard G, Kalaidzidis Y, etal |title=The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends |journal=Nature |volume=441 |issue= 7089 |pages= 115–9 |year= 2006 |pmid= 16672973 |doi= 10.1038/nature04736 }}
*{{cite journal | author=Helenius J, Brouhard G, Kalaidzidis Y, ''et al.'' |title=The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends. |journal=Nature |volume=441 |issue= 7089 |pages= 115-9 |year= 2006 |pmid= 16672973 |doi= 10.1038/nature04736 }}
*{{cite journal   |vauthors=Sun Y, Huang YC, Xu QZ, etal |title=HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=65 |issue= 3 |pages= 842–50 |year= 2006 |pmid= 16751065 |doi= 10.1016/j.ijrobp.2006.02.040 }}
*{{cite journal | author=Sun Y, Huang YC, Xu QZ, ''et al.'' |title=HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation. |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=65 |issue= 3 |pages= 842-50 |year= 2006 |pmid= 16751065 |doi= 10.1016/j.ijrobp.2006.02.040 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11004}}
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Latest revision as of 05:42, 30 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.[1][2]

The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.[2]

References

  1. ↑ Kim IG, Jun DY, Sohn U, Kim YH (Feb 1998). "Cloning and expression of human mitotic centromere-associated kinesin gene". Biochim Biophys Acta. 1359 (3): 181–6. doi:10.1016/s0167-4889(97)00103-1. PMID 9434124.
  2. ↑ 2.0 2.1 "Entrez Gene: KIF2C kinesin family member 2C".

Further reading



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