AMY2B: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Alpha-amylase 2B''' is an [[enzyme]] that in humans is encoded by the ''AMY2B'' [[gene]].<ref name="pmid8268204">{{cite journal | vauthors = Omichi K, Hase S | title = Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene | journal = Biochimica et Biophysica Acta | volume = 1203 | issue = 2 | pages = 224–9 | date = December 1993 | pmid = 8268204 | pmc =  | doi = 10.1016/0167-4838(93)90087-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280| access-date = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_AMY2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b2y.
| PDB = {{PDB2|1b2y}}, {{PDB2|1bsi}}, {{PDB2|1c8q}}, {{PDB2|1cpu}}, {{PDB2|1hny}}, {{PDB2|1jxj}}, {{PDB2|1jxk}}, {{PDB2|1kb3}}, {{PDB2|1kbb}}, {{PDB2|1kbk}}, {{PDB2|1kgu}}, {{PDB2|1kgw}}, {{PDB2|1kgx}}, {{PDB2|1mfu}}, {{PDB2|1mfv}}, {{PDB2|1nm9}}, {{PDB2|1q4n}}, {{PDB2|1smd}}, {{PDB2|1u2y}}, {{PDB2|1u30}}, {{PDB2|1u33}}, {{PDB2|1xcw}}, {{PDB2|1xcx}}, {{PDB2|1xd0}}, {{PDB2|1xd1}}, {{PDB2|1xgz}}, {{PDB2|1xh0}}, {{PDB2|1xh1}}, {{PDB2|1xh2}}, {{PDB2|1xv8}}, {{PDB2|1z32}}, {{PDB2|2cpu}}, {{PDB2|3cpu}}
| Name = Amylase, alpha 2B (pancreatic)
| HGNCid = 478
| Symbol = AMY2B
| AltSymbols =; AMY2
| OMIM = 104660
| ECnumber = 
| Homologene = 88874
| MGIid = 
| GeneAtlas_image1 = PBB_GE_AMY2B_208498_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004556 |text = alpha-amylase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 280
    | Hs_Ensembl = ENSG00000197839
    | Hs_RefseqProtein = NP_066188
    | Hs_RefseqmRNA = NM_020978
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 103897960
    | Hs_GenLoc_end = 103923675
    | Hs_Uniprot = P19961
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Amylase, alpha 2B (pancreatic)''', also known as '''AMY2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Amylase]]s are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and [[glycogen]]. The human genome has a cluster of several amylase genes that are expressed at high levels in either [[salivary gland]] or [[pancreas]]. This gene encodes an amylase isoenzyme produced by the pancreas.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.<ref name="entrez">{{cite web | title = Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== External links ==
* {{UCSC gene info|AMY2B}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kaczmarek MJ, Rosenmund H | title = The action of human pancreatic and salivary isoamylases on starch and glycogen | journal = Clinica Chimica Acta; International Journal of Clinical Chemistry | volume = 79 | issue = 1 | pages = 69–73 | date = August 1977 | pmid = 890964 | doi = 10.1016/0009-8981(77)90462-4 }}
| citations =
* {{cite journal | vauthors = Groot PC, Mager WH, Henriquez NV, Pronk JC, Arwert F, Planta RJ, Eriksson AW, Frants RR | title = Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers | journal = Genomics | volume = 8 | issue = 1 | pages = 97–105 | date = September 1990 | pmid = 2081604 | doi = 10.1016/0888-7543(90)90230-R }}
*{{cite journal | author=Kaczmarek MJ, Rosenmund H |title=The action of human pancreatic and salivary isoamylases on starch and glycogen. |journal=Clin. Chim. Acta |volume=79 |issue= 1 |pages= 69-73 |year= 1977 |pmid= 890964 |doi= }}
* {{cite journal | vauthors = Yokouchi H, Horii A, Emi M, Tomita N, Doi S, Ogawa M, Mori T, Matsubara K | title = Cloning and characterization of a third type of human alpha-amylase gene, AMY2B | journal = Gene | volume = 90 | issue = 2 | pages = 281–6 | date = June 1990 | pmid = 2401405 | doi = 10.1016/0378-1119(90)90191-S }}
*{{cite journal | author=Groot PC, Mager WH, Henriquez NV, ''et al.'' |title=Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers. |journal=Genomics |volume=8 |issue= 1 |pages= 97-105 |year= 1991 |pmid= 2081604 |doi= }}
* {{cite journal | vauthors = Gumucio DL, Wiebauer K, Caldwell RM, Samuelson LC, Meisler MH | title = Concerted evolution of human amylase genes | journal = Molecular and Cellular Biology | volume = 8 | issue = 3 | pages = 1197–205 | date = March 1988 | pmid = 2452973 | pmc = 363264 | doi =  }}
*{{cite journal | author=Yokouchi H, Horii A, Emi M, ''et al.'' |title=Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. |journal=Gene |volume=90 |issue= 2 |pages= 281-6 |year= 1990 |pmid= 2401405 |doi= }}
* {{cite journal | vauthors = Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH | title = Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene | journal = Nucleic Acids Research | volume = 16 | issue = 17 | pages = 8261–76 | date = September 1988 | pmid = 2458567 | pmc = 338557 | doi = 10.1093/nar/16.17.8261 }}
*{{cite journal | author=Gumucio DL, Wiebauer K, Caldwell RM, ''et al.'' |title=Concerted evolution of human amylase genes. |journal=Mol. Cell. Biol. |volume=8 |issue= 3 |pages= 1197-205 |year= 1988 |pmid= 2452973 |doi=  }}
* {{cite journal | vauthors = Tomita N, Horii A, Doi S, Yokouchi H, Shiosaki K, Higashiyama M, Matsuura N, Ogawa M, Mori T, Matsubara K | title = A novel type of human alpha-amylase produced in lung carcinoid tumor | journal = Gene | volume = 76 | issue = 1 | pages = 11–8 | date = March 1989 | pmid = 2701942 | doi = 10.1016/0378-1119(89)90003-6 }}
*{{cite journal | author=Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH |title=Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8261-76 |year= 1988 |pmid= 2458567 |doi= }}
* {{cite journal | vauthors = Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR | title = The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes | journal = Genomics | volume = 5 | issue = 1 | pages = 29–42 | date = July 1989 | pmid = 2788608 | doi = 10.1016/0888-7543(89)90083-9 }}
*{{cite journal | author=Tomita N, Horii A, Doi S, ''et al.'' |title=A novel type of human alpha-amylase produced in lung carcinoid tumor. |journal=Gene |volume=76 |issue= 1 |pages= 11-8 |year= 1989 |pmid= 2701942 |doi= }}
* {{cite journal | vauthors = Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR | title = Human pancreatic amylase is encoded by two different genes | journal = Nucleic Acids Research | volume = 16 | issue = 10 | pages = 4724 | date = May 1988 | pmid = 3260028 | pmc = 336663 | doi = 10.1093/nar/16.10.4724 }}
*{{cite journal | author=Groot PC, Bleeker MJ, Pronk JC, ''et al.'' |title=The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes. |journal=Genomics |volume=5 |issue= 1 |pages= 29-42 |year= 1989 |pmid= 2788608 |doi= }}
* {{cite journal | vauthors = Tricoli JV, Shows TB | title = Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1 | journal = Somatic Cell and Molecular Genetics | volume = 10 | issue = 2 | pages = 205–10 | date = March 1984 | pmid = 6608795 | doi = 10.1007/BF01534909 }}
*{{cite journal | author=Groot PC, Bleeker MJ, Pronk JC, ''et al.'' |title=Human pancreatic amylase is encoded by two different genes. |journal=Nucleic Acids Res. |volume=16 |issue= 10 |pages= 4724 |year= 1988 |pmid= 3260028 |doi= }}
* {{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 8 | issue = 2 | pages = 85–95 | date = April 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 }}
*{{cite journal | author=Tricoli JV, Shows TB |title=Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1. |journal=Somat. Cell Mol. Genet. |volume=10 |issue= 2 |pages= 205-10 |year= 1984 |pmid= 6608795 |doi= }}
* {{cite journal | vauthors = Aughsteen AA | title = A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas | journal = Saudi Medical Journal | volume = 22 | issue = 5 | pages = 410–5 | date = May 2001 | pmid = 11376382 | doi =  }}
*{{cite journal  | author=Omichi K, Hase S |title=Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. |journal=Biochim. Biophys. Acta |volume=1203 |issue= 2 |pages= 224-9 |year= 1994 |pmid= 8268204 |doi=  }}
* {{cite journal | vauthors = Koyama I, Komine S, Iino N, Hokari S, Igarashi S, Alpers DH, Komoda T | title = alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues | journal = Clinica Chimica Acta; International Journal of Clinical Chemistry | volume = 309 | issue = 1 | pages = 73–83 | date = July 2001 | pmid = 11408008 | doi = 10.1016/S0009-8981(01)00501-0 }}
*{{cite journal | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi= }}
* {{cite journal | vauthors = Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C | title = Detection of large-scale variation in the human genome | journal = Nature Genetics | volume = 36 | issue = 9 | pages = 949–51 | date = September 2004 | pmid = 15286789 | doi = 10.1038/ng1416 }}
*{{cite journal | author=Aughsteen AA |title=A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas. |journal=Saudi medical journal |volume=22 |issue= 5 |pages= 410-5 |year= 2001 |pmid= 11376382 |doi=  }}
*{{cite journal | author=Koyama I, Komine S, Iino N, ''et al.'' |title=alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues. |journal=Clin. Chim. Acta |volume=309 |issue= 1 |pages= 73-83 |year= 2001 |pmid= 11408008 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Iafrate AJ, Feuk L, Rivera MN, ''et al.'' |title=Detection of large-scale variation in the human genome. |journal=Nat. Genet. |volume=36 |issue= 9 |pages= 949-51 |year= 2004 |pmid= 15286789 |doi= 10.1038/ng1416 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=280}}


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Latest revision as of 04:45, 7 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.[1][2]

Function

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[2]

References

  1. ↑ Omichi K, Hase S (December 1993). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochimica et Biophysica Acta. 1203 (2): 224–9. doi:10.1016/0167-4838(93)90087-8. PMID 8268204.
  2. ↑ 2.0 2.1 "Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)".

External links

Further reading


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