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{{Infobox_gene}}
'''Ras-related protein Rab-25''' is a [[protein]] that in humans is encoded by the ''RAB25'' [[gene]].<ref name="pmid11697911">{{cite journal |vauthors=Pereira-Leal JB, Seabra MC | title = Evolution of the Rab family of small GTP-binding proteins | journal = J Mol Biol | volume = 313 | issue = 4 | pages = 889–901 |date=November 2001 | pmid = 11697911 | pmc =  | doi = 10.1006/jmbi.2001.5072 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB25 RAB25, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57111| accessdate = }}</ref>
It is thought to act as a promoter of tumor development.<ref>{{cite journal|last1=Kessler|first1=D|last2=Gruen|first2=GC|last3=Heider|first3=D|last4=Morgner|first4=J|last5=Reis|first5=H|last6=Schmid|first6=KW|last7=Jendrossek|first7=V|title=The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.|journal=Cellular Physiology and Biochemistry|date=2012|volume=29|issue=5-6|pages=647–56|pmid=22613965|doi=10.1159/000295249}}</ref>
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==Interactions==
RAB25 has been shown to [[Protein-protein interaction|interact]] with [[RAB11FIP2]]<ref name=pmid11495908>{{cite journal |last=Hales |first=C M |authorlink= |author2=Griner R |author3=Hobdy-Henderson K C |author4=Dorn M C |author5=Hardy D |author6=Kumar R |author7=Navarre J |author8=Chan E K |author9=Lapierre L A |author10=Goldenring J R  |date=October 2001 |title=Identification and characterization of a family of Rab11-interacting proteins |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=39067–75 |publisher= |location = United States| issn = 0021-9258| pmid = 11495908 |doi = 10.1074/jbc.M104831200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11481332>{{cite journal |last=Prekeris |first=R |authorlink= |author2=Davies J M |author3=Scheller R H  |date=October 2001 |title=Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=38966–70 |publisher= |location = United States| issn = 0021-9258| pmid = 11481332 |doi = 10.1074/jbc.M106133200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RAB11FIP5]].<ref name=pmid11495908/><ref name=pmid11481332/>
==References==
{{Reflist}}
==Further reading==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  |vauthors=Goldenring JR, Shen KR, Vaughan HD, Modlin IM |title=Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18419–22 |year= 1993 |pmid= 8360141 |doi=  }}
*{{cite journal  |vauthors=Ray GS, Lee JR, Nwokeji K, etal |title=Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. |journal=Lab. Invest. |volume=77 |issue= 5 |pages= 503–11 |year= 1997 |pmid= 9389793 |doi=  }}
*{{cite journal  |vauthors=Lapierre LA, Kumar R, Hales CM, etal |title=Myosin vb is associated with plasma membrane recycling systems. |journal=Mol. Biol. Cell |volume=12 |issue= 6 |pages= 1843–57 |year= 2001 |pmid= 11408590 |doi=  10.1091/mbc.12.6.1843| pmc=37346  }}
*{{cite journal  |vauthors=Prekeris R, Davies JM, Scheller RH |title=Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38966–70 |year= 2001 |pmid= 11481332 |doi= 10.1074/jbc.M106133200 }}
*{{cite journal  |vauthors=Hales CM, Griner R, Hobdy-Henderson KC, etal |title=Identification and characterization of a family of Rab11-interacting proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39067–75 |year= 2001 |pmid= 11495908 |doi= 10.1074/jbc.M104831200 }}
*{{cite journal  |vauthors=Suzuki H, Fukunishi Y, Kagawa I, etal |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101  | pmc=311163 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B }}
*{{cite journal  |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
*{{cite journal  |vauthors=Fan Y, Xin XY, Chen BL, Ma X |title=Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. |journal=Pathology |volume=38 |issue= 6 |pages= 561–7 |year= 2007 |pmid= 17393986 |doi=10.1080/00313020601024037  }}
}}
{{Refend}}
{{PDB Gallery|geneid=57111}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAB25_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2oil.
| PDB = {{PDB2|2oil}}
| Name = RAB25, member RAS oncogene family
| HGNCid = 18238
| Symbol = RAB25
| AltSymbols =; CATX-8
| OMIM = 
| ECnumber = 
| Homologene = 22995
| MGIid = 1858203
| GeneAtlas_image1 = PBB_GE_RAB25_218186_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57111
    | Hs_Ensembl = ENSG00000132698
    | Hs_RefseqProtein = NP_065120
    | Hs_RefseqmRNA = NM_020387
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154297575
    | Hs_GenLoc_end = 154306920
    | Hs_Uniprot = P57735
    | Mm_EntrezGene = 53868
    | Mm_Ensembl = ENSMUSG00000008601
    | Mm_RefseqmRNA = NM_016899
    | Mm_RefseqProtein = NP_058595
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88627956
    | Mm_GenLoc_end = 88634206
    | Mm_Uniprot = Q0PD30
  }}
}}
'''RAB25, member RAS oncogene family''', also known as '''RAB25''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB25 RAB25, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57111| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Goldenring JR, Shen KR, Vaughan HD, Modlin IM |title=Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18419-22 |year= 1993 |pmid= 8360141 |doi=  }}
*{{cite journal  | author=Ray GS, Lee JR, Nwokeji K, ''et al.'' |title=Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. |journal=Lab. Invest. |volume=77 |issue= 5 |pages= 503-11 |year= 1997 |pmid= 9389793 |doi=  }}
*{{cite journal  | author=Lapierre LA, Kumar R, Hales CM, ''et al.'' |title=Myosin vb is associated with plasma membrane recycling systems. |journal=Mol. Biol. Cell |volume=12 |issue= 6 |pages= 1843-57 |year= 2001 |pmid= 11408590 |doi=  }}
*{{cite journal  | author=Prekeris R, Davies JM, Scheller RH |title=Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38966-70 |year= 2001 |pmid= 11481332 |doi= 10.1074/jbc.M106133200 }}
*{{cite journal  | author=Hales CM, Griner R, Hobdy-Henderson KC, ''et al.'' |title=Identification and characterization of a family of Rab11-interacting proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39067-75 |year= 2001 |pmid= 11495908 |doi= 10.1074/jbc.M104831200 }}
*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
*{{cite journal  | author=Pereira-Leal JB, Seabra MC |title=Evolution of the Rab family of small GTP-binding proteins. |journal=J. Mol. Biol. |volume=313 |issue= 4 |pages= 889-901 |year= 2001 |pmid= 11697911 |doi= 10.1006/jmbi.2001.5072 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Fan Y, Xin XY, Chen BL, Ma X |title=Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. |journal=Pathology |volume=38 |issue= 6 |pages= 561-7 |year= 2007 |pmid= 17393986 |doi=  }}
}}
{{refend}}


{{protein-stub}}
{{Gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 01:35, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene.[1][2] It is thought to act as a promoter of tumor development.[3]

Interactions

RAB25 has been shown to interact with RAB11FIP2[4][5] and RAB11FIP5.[4][5]

References

  1. ↑ Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
  2. ↑ "Entrez Gene: RAB25 RAB25, member RAS oncogene family".
  3. ↑ Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–56. doi:10.1159/000295249. PMID 22613965.
  4. ↑ 4.0 4.1 Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. United States. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
  5. ↑ 5.0 5.1 Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. United States. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

Further reading



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