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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Ficolin-3''' is a [[protein]] that in humans is encoded by the ''FCN3'' [[gene]].  Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata [[antigen]] that was previously found as an [[autoantigen]] in patients who lived in the city of [[Hakata-ku, Fukuoka|Hakata]].<ref name="pmid9694814">{{cite journal | vauthors = Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N | title = Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family | journal = J Biol Chem | volume = 273 | issue = 33 | pages = 20721–7 |date=Sep 1998 | pmid = 9694814 | pmc =  | doi =10.1074/jbc.273.33.20721 }}</ref><ref name="pmid10330454">{{cite journal | vauthors = Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N | title = Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile | journal = J Histochem Cytochem | volume = 47 | issue = 6 | pages = 777–86 |date=Jun 1999 | pmid = 10330454 | pmc =  | doi =  10.1177/002215549904700607}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8547| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_FCN3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2j5z.
| PDB = {{PDB2|2j5z}}, {{PDB2|2j60}}, {{PDB2|2j64}}
| Name = Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
| HGNCid = 3625
| Symbol = FCN3
| AltSymbols =; FCNH; HAKA1; MGC22543
| OMIM = 604973
| ECnumber =
| Homologene = 80190
| MGIid =
  | GeneAtlas_image1 = PBB_GE_FCN3_205866_at_tn.png
  | Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8547
    | Hs_Ensembl = ENSG00000142748
    | Hs_RefseqProtein = NP_003656
    | Hs_RefseqmRNA = NM_003665
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 27568189
    | Hs_GenLoc_end = 27573916
    | Hs_Uniprot = O75636
    | Mm_EntrezGene =   
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)''', also known as '''FCN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8547| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8547| accessdate = }}</ref>
| summary_text = Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yae Y, Inaba S, Sato H, ''et al.'' |title=Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. |journal=Biochim. Biophys. Acta |volume=1078 |issue= 3 |pages= 369-76 |year= 1991 |pmid= 1859827 |doi=  }}
*{{cite journal  | vauthors=Yae Y, Inaba S, Sato H |title=Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus |journal=Biochim. Biophys. Acta |volume=1078 |issue= 3 |pages= 369–76 |year= 1991 |pmid= 1859827 |doi= 10.1016/0167-4838(91)90158-v }}
*{{cite journal  | author=Inaba S, Okochi K, Yae Y, ''et al.'' |title=Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system. |journal=Fukuoka Igaku Zasshi |volume=81 |issue= 9 |pages= 284-91 |year= 1991 |pmid= 2276712 |doi= }}
*{{cite journal  | vauthors=Inaba S, Okochi K, Yae Y |title=Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system |journal=Fukuoka Igaku Zasshi |volume=81 |issue= 9 |pages= 284–91 |year= 1991 |pmid= 2276712 |doi=   }}
*{{cite journal  | author=Sugimoto R, Yae Y, Akaiwa M, ''et al.'' |title=Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 20721-7 |year= 1998 |pmid= 9694814 |doi=  }}
*{{cite journal  | vauthors=Matsushita M, Kuraya M, Hamasaki N |title=Activation of the lectin complement pathway by H-ficolin (Hakata antigen) |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3502–6 |year= 2002 |pmid= 11907111 |doi= 10.4049/jimmunol.168.7.3502 }}
*{{cite journal  | author=Akaiwa M, Yae Y, Sugimoto R, ''et al.'' |title=Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. |journal=J. Histochem. Cytochem. |volume=47 |issue= 6 |pages= 777-86 |year= 1999 |pmid= 10330454 |doi=  }}
*{{cite journal  | vauthors=Tsujimura M, Miyazaki T, Kojima E |title=Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth |journal=Clin. Chim. Acta |volume=325 |issue= 1–2 |pages= 139–46 |year= 2003 |pmid= 12367778 |doi=10.1016/S0009-8981(02)00274-7    }}
*{{cite journal  | author=Matsushita M, Kuraya M, Hamasaki N, ''et al.'' |title=Activation of the lectin complement pathway by H-ficolin (Hakata antigen). |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3502-6 |year= 2002 |pmid= 11907111 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  }}
*{{cite journal  | author=Tsujimura M, Miyazaki T, Kojima E, ''et al.'' |title=Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth. |journal=Clin. Chim. Acta |volume=325 |issue= 1-2 |pages= 139-46 |year= 2003 |pmid= 12367778 |doi= }}
*{{cite journal  | vauthors=Zeng L, Dai J, Ying K |title=Identification of a novel human angiopoietin-like gene expressed mainly in heart |journal=J. Hum. Genet. |volume=48 |issue= 3 |pages= 159–62 |year= 2003 |pmid= 12624729 |doi= 10.1007/s100380300025   }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697  }}
*{{cite journal  | author=Zeng L, Dai J, Ying K, ''et al.'' |title=Identification of a novel human angiopoietin-like gene expressed mainly in heart. |journal=J. Hum. Genet. |volume=48 |issue= 3 |pages= 159-62 |year= 2003 |pmid= 12624729 |doi= 10.1007/s100380300025 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285   }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Anderson NL, Polanski M, Pieper R |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200   }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal  | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117   }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943  }}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | vauthors=Muzny DM, Scherer SE, Kaul R |title=The DNA sequence, annotation and analysis of human chromosome 3 |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728   }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | vauthors=Garlatti V, Belloy N, Martin L |title=Structural insights into the innate immune recognition specificities of L- and H-ficolins |journal=EMBO J. |volume=26 |issue= 2 |pages= 623–33 |year= 2007 |pmid= 17215869 |doi= 10.1038/sj.emboj.7601500 | pmc=1783469  }}
*{{cite journal  | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
*{{cite journal  | vauthors=Honoré C, Hummelshoj T, Hansen BE |title=The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells |journal=Arthritis Rheum. |volume=56 |issue= 5 |pages= 1598–607 |year= 2007 |pmid= 17469142 |doi= 10.1002/art.22564   }}
*{{cite journal  | author=Garlatti V, Belloy N, Martin L, ''et al.'' |title=Structural insights into the innate immune recognition specificities of L- and H-ficolins. |journal=EMBO J. |volume=26 |issue= 2 |pages= 623-33 |year= 2007 |pmid= 17215869 |doi= 10.1038/sj.emboj.7601500 }}
*{{cite journal  | author=Honoré C, Hummelshoj T, Hansen BE, ''et al.'' |title=The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. |journal=Arthritis Rheum. |volume=56 |issue= 5 |pages= 1598-607 |year= 2007 |pmid= 17469142 |doi= 10.1002/art.22564 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8547}}
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[[Category:Ficolins]]


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Latest revision as of 14:54, 13 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ficolin-3 is a protein that in humans is encoded by the FCN3 gene. Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata antigen that was previously found as an autoantigen in patients who lived in the city of Hakata.[1][2][3]

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.[3]

References

  1. ↑ Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N (Sep 1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J Biol Chem. 273 (33): 20721–7. doi:10.1074/jbc.273.33.20721. PMID 9694814.
  2. ↑ Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N (Jun 1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J Histochem Cytochem. 47 (6): 777–86. doi:10.1177/002215549904700607. PMID 10330454.
  3. ↑ 3.0 3.1 "Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)".

Further reading


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