QSOX1: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''Sulfhydryl oxidase 1''' is an [[enzyme]] that in humans is encoded by the ''QSOX1'' [[gene]].<ref name="pmid9878249">{{cite journal | vauthors = Coppock DL, Cina-Poppe D, Gilleran S | title = The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1 | journal = Genomics | volume = 54 | issue = 3 | pages = 460–8 |date=Feb 1999 | pmid = 9878249 | pmc =  | doi = 10.1006/geno.1998.5605 }}</ref><ref name="pmid8396966">{{cite journal | vauthors = Coppock DL, Kopman C, Scandalis S, Gilleran S | title = Preferential gene expression in quiescent human lung fibroblasts | journal = Cell Growth Differ | volume = 4 | issue = 6 | pages = 483–93 |date=Oct 1993 | pmid = 8396966 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: QSCN6 quiescin Q6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5768| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = Quiescin Q6
| HGNCid = 9756
| Symbol = QSCN6
| AltSymbols =; Q6; QSOX1
| OMIM = 603120
| ECnumber = 
| Homologene = 37690
| MGIid = 1330818
| GeneAtlas_image1 = PBB_GE_QSCN6_201482_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015035 |text = protein disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0016972 |text = thiol oxidase activity}}
  | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5768
    | Hs_Ensembl = ENSG00000116260
    | Hs_RefseqProtein = NP_001004128
    | Hs_RefseqmRNA = NM_001004128
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 178390592
    | Hs_GenLoc_end = 178439788
    | Hs_Uniprot = O00391
    | Mm_EntrezGene = 104009
    | Mm_Ensembl = ENSMUSG00000033684
    | Mm_RefseqmRNA = NM_001024945
    | Mm_RefseqProtein = NP_001020116
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 157540373
    | Mm_GenLoc_end = 157575117
    | Mm_Uniprot = Q8BND5
  }}
}}
'''Quiescin Q6''', also known as '''QSCN6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: QSCN6 quiescin Q6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5768| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: QSCN6 quiescin Q6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5768| accessdate = }}</ref>
| summary_text = This gene encodes a [[protein]] that contains domains of [[thioredoxin]] and ERV1, members of two long-standing gene families. The [[gene expression]] is induced as [[fibroblasts]] begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different [[isoforms]] have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Thorpe C, Hoober KL, Raje S, ''et al.'' |title=Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. |journal=Arch. Biochem. Biophys. |volume=405 |issue= 1 |pages= 1-12 |year= 2002 |pmid= 12176051 |doi= }}
*{{cite journal   |vauthors=Thorpe C, Hoober KL, Raje S, etal |title=Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. |journal=Arch. Biochem. Biophys. |volume=405 |issue= 1 |pages= 1–12 |year= 2002 |pmid= 12176051 |doi=10.1016/S0003-9861(02)00337-5  }}
*{{cite journal  | author=Coppock DL, Kopman C, Scandalis S, Gilleran S |title=Preferential gene expression in quiescent human lung fibroblasts. |journal=Cell Growth Differ. |volume=4 |issue= 6 |pages= 483-93 |year= 1993 |pmid= 8396966 |doi=  }}
*{{cite journal   |vauthors=Hoober KL, Glynn NM, Burnside J, etal |title=Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 31759–62 |year= 1999 |pmid= 10542195 |doi=10.1074/jbc.274.45.31759 }}
*{{cite journal  | author=Coppock DL, Cina-Poppe D, Gilleran S |title=The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. |journal=Genomics |volume=54 |issue= 3 |pages= 460-8 |year= 1999 |pmid= 9878249 |doi= 10.1006/geno.1998.5605 }}
*{{cite journal  | vauthors=Coppock D, Kopman C, Gudas J, Cina-Poppe DA |title=Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. |journal=Biochem. Biophys. Res. Commun. |volume=269 |issue= 2 |pages= 604–10 |year= 2000 |pmid= 10708601 |doi= 10.1006/bbrc.2000.2324 }}
*{{cite journal | author=Hoober KL, Glynn NM, Burnside J, ''et al.'' |title=Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 31759-62 |year= 1999 |pmid= 10542195 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Coppock D, Kopman C, Gudas J, Cina-Poppe DA |title=Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. |journal=Biochem. Biophys. Res. Commun. |volume=269 |issue= 2 |pages= 604-10 |year= 2000 |pmid= 10708601 |doi= 10.1006/bbrc.2000.2324 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Radom J, Colin D, Thiebault F, etal |title=Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain. |journal=Biochim. Biophys. Acta |volume=1759 |issue= 5 |pages= 225–33 |year= 2006 |pmid= 16806532 |doi= 10.1016/j.bbaexp.2006.04.008 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Chakravarthi S, Jessop CE, Willer M, etal |title=Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. |journal=Biochem. J. |volume=404 |issue= 3 |pages= 403–11 |year= 2007 |pmid= 17331072 |doi= 10.1042/BJ20061510 | pmc=1896280 }}
*{{cite journal | author=Radom J, Colin D, Thiebault F, ''et al.'' |title=Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain. |journal=Biochim. Biophys. Acta |volume=1759 |issue= 5 |pages= 225-33 |year= 2006 |pmid= 16806532 |doi= 10.1016/j.bbaexp.2006.04.008 }}
*{{cite journal   |vauthors=Jaje J, Wolcott HN, Fadugba O, etal |title=A flavin-dependent sulfhydryl oxidase in bovine milk. |journal=Biochemistry |volume=46 |issue= 45 |pages= 13031–40 |year=  2007|pmid= 17944490 |doi= 10.1021/bi7016975 | pmc=2518652 }}
*{{cite journal | author=Chakravarthi S, Jessop CE, Willer M, ''et al.'' |title=Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. |journal=Biochem. J. |volume=404 |issue= 3 |pages= 403-11 |year= 2007 |pmid= 17331072 |doi= 10.1042/BJ20061510 }}
*{{cite journal | author=Jaje J, Wolcott HN, Fadugba O, ''et al.'' |title=A flavin-dependent sulfhydryl oxidase in bovine milk. |journal=Biochemistry |volume=46 |issue= 45 |pages= 13031-40 |year=  |pmid= 17944490 |doi= 10.1021/bi7016975 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 14:31, 20 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene.[1][2][3]

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.[3]

References

  1. ↑ Coppock DL, Cina-Poppe D, Gilleran S (Feb 1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1". Genomics. 54 (3): 460–8. doi:10.1006/geno.1998.5605. PMID 9878249.
  2. ↑ Coppock DL, Kopman C, Scandalis S, Gilleran S (Oct 1993). "Preferential gene expression in quiescent human lung fibroblasts". Cell Growth Differ. 4 (6): 483–93. PMID 8396966.
  3. ↑ 3.0 3.1 "Entrez Gene: QSCN6 quiescin Q6".

Further reading


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