RGS13: Difference between revisions

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'''Regulator of G-protein signaling 13''' is a [[protein]] that in humans is encoded by the ''RGS13'' [[gene]].<ref name="pmid11875076">{{cite journal |vauthors=Johnson EN, Druey KM | title = Functional characterization of the G protein regulator RGS13 | journal = J Biol Chem | volume = 277 | issue = 19 | pages = 16768–16774 |date=May 2002 | pmid = 11875076 | pmc =  | doi = 10.1074/jbc.M200751200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS13 regulator of G-protein signalling 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6003| accessdate = }}</ref>
'''Regulator of G-protein signaling 13''' is a [[protein]] that in humans is encoded by the ''RGS13'' [[gene]].<ref name="pmid11875076">{{cite journal |vauthors=Johnson EN, Druey KM | title = Functional characterization of the G protein regulator RGS13 | journal = J Biol Chem | volume = 277 | issue = 19 | pages = 16768–16774 |date=May 2002 | pmid = 11875076 | pmc =  | doi = 10.1074/jbc.M200751200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS13 regulator of G-protein signalling 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6003| accessdate = }}</ref>


'''RGS 13''' is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.<ref name="pmid18026105">{{cite journal |vauthors=Bansal G, Xie Z, Rao S, Nocka KH, Druey KM | title = Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13 | journal = Nat. Immunol. | volume = 9 | issue = 1 | pages = 73–80 | year = 2008 | pmid = 18026105 | doi = 10.1038/ni1533 | pmc = 2387203 }}</ref>
'''RGS 13''' is a member of R4 subfamily of RGS ([[Regulator of G protein signaling|Regulators of G Protein Signaling]]) proteins which have only short [[Protein primary structure|peptide sequences]] flanking the RGS domain. RGS 13 suppresses the [[immunoglobulin E]]- mediated [[Allergic response|allergic responses]].<ref name="pmid18026105">{{cite journal |vauthors=Bansal G, Xie Z, Rao S, Nocka KH, Druey KM | title = Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13 | journal = Nat. Immunol. | volume = 9 | issue = 1 | pages = 73–80 | year = 2008 | pmid = 18026105 | doi = 10.1038/ni1533 | pmc = 2387203 }}</ref>


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| summary_text = The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.<ref name="entrez"/>
| summary_text = The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with ''[[S. cerevisiae]]'' SST2 and ''[[Caenorhabditis elegans|C. elegans]]'' egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate [[GTPase]] activity of [[G protein]] alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to [[G protein-coupled receptor]] activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same [[isoform]] exist.<ref name="entrez"/>
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Latest revision as of 08:33, 13 March 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.[1][2]

RGS 13 is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.[3]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[2]

References

  1. ↑ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
  2. ↑ 2.0 2.1 "Entrez Gene: RGS13 regulator of G-protein signalling 13".
  3. ↑ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

Further reading



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