S100A14: Difference between revisions

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== Function ==
== Function ==


This gene encodes a member of the [[S100 protein]] family which contains an [[EF-hand]] motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.<ref>{{cite journal | vauthors = Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY | title = Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery | journal = Oncology Reports | volume = 23 | issue = 1 | date = Jan 2010 | pmid = 19956863 | pages=45–52}}</ref><ref>{{cite journal | vauthors = Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z | title = Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma | journal = Cancer Research | volume = 69 | issue = 8 | date = Apr 2009 | pmid = 19351828 | doi = 10.1158/0008-5472.CAN-08-4231 | pages=3451–7}}</ref>
This gene encodes a member of the [[S100 protein]] family which contains an [[EF-hand]] motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.<ref>{{cite journal | vauthors = Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY | title = Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery | journal = Oncology Reports | volume = 23 | issue = 1 | date = Jan 2010 | pmid = 19956863 | pages=45–52 | doi = 10.3892/or_00000604 }}</ref><ref>{{cite journal | vauthors = Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z | title = Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma | journal = Cancer Research | volume = 69 | issue = 8 | date = Apr 2009 | pmid = 19351828 | doi = 10.1158/0008-5472.CAN-08-4231 | pages=3451–7}}</ref>


== References ==
== References ==

Latest revision as of 18:59, 16 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.[1]

Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.[2][3]

References

  1. ↑ "Entrez Gene: S100 calcium binding protein A14".
  2. ↑ Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi:10.3892/or_00000604. PMID 19956863.
  3. ↑ Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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