Natriuretic peptide precursor C: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Natriuretic peptide precursor C''', also known as '''NPPC''', is a [[protein]] that in humans is encoded by the ''NPPC'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPPC natriuretic peptide precursor C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4880| accessdate = }}</ref><ref name="pmid8330189">{{cite journal |vauthors=Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O | title = C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid | journal = Brain Res. | volume = 612 | issue = 1–2 | pages = 104–9 |date=May 1993 | pmid = 8330189 | doi = 10.1016/0006-8993(93)91649-D| url =  }}</ref><ref name="pmid7698765">{{cite journal |vauthors=Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K | title = Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC) | journal = Genomics | volume = 24 | issue = 2 | pages = 383–7 |date=November 1994 | pmid = 7698765 | doi = 10.1006/geno.1994.1633 | url =  }}</ref> The precursor NPPC protein is cleaved to the 22 [[amino acid]] [[peptide]] '''C-type natriuretic peptide''' (''CNP'').
'''Natriuretic peptide precursor C''', also known as '''NPPC''', is a [[protein]] that in humans is encoded by the ''NPPC'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPPC natriuretic peptide precursor C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4880| access-date = }}</ref><ref name="pmid8330189">{{cite journal | vauthors = Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O | title = C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid | journal = Brain Research | volume = 612 | issue = 1-2 | pages = 104–9 | date = May 1993 | pmid = 8330189 | doi = 10.1016/0006-8993(93)91649-D }}</ref><ref name="pmid7698765">{{cite journal | vauthors = Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K | title = Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC) | journal = Genomics | volume = 24 | issue = 2 | pages = 383–7 | date = November 1994 | pmid = 7698765 | doi = 10.1006/geno.1994.1633 }}</ref> The precursor NPPC protein is cleaved to the 22 [[amino acid]] [[peptide]] '''C-type natriuretic peptide''' (''CNP'').


==Function==
== Function ==


[[Natriuretic peptide]]s comprise a family of 3 structurally related molecules: atrial natriuretic peptide ([[atrial natriuretic peptide|ANP]]), brain natriuretic peptide ([[brain natriuretic peptide|BNP]]), and C-type natriuretic peptide (CNP), encoded by a gene symbolized ''NPPC''. These peptides possess potent [[Natriuresis|natriuretic]], [[diuretic]], and [[vasodilation|vasodilating]] activities and are implicated in body fluid homeostasis and blood pressure control.<ref name="entrez" />
[[Natriuretic peptide]]s comprise a family of 3 structurally related molecules: atrial natriuretic peptide ([[atrial natriuretic peptide|ANP]]), brain natriuretic peptide ([[brain natriuretic peptide|BNP]]), and C-type natriuretic peptide (CNP), encoded by a gene symbolized ''NPPC''. These peptides possess potent [[Natriuresis|natriuretic]], [[diuretic]], and [[vasodilation|vasodilating]] activities and are implicated in body fluid homeostasis and blood pressure control.<ref name="entrez" />
Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective [[agonist]] for the B-type natriuretic receptor ([[atrial natriuretic peptide receptor|NPRB]]) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).<ref name="pmid8959763">{{cite journal |vauthors=Barr CS, Rhodes P, Struthers AD | title = C-type natriuretic peptide | journal = Peptides | volume = 17 | issue = 7 | pages = 1243–51 | year = 1996 | pmid = 8959763 | doi = 10.1016/S0196-9781(96)00110-6 | url =   }}</ref>
Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective [[agonist]] for the B-type natriuretic receptor ([[atrial natriuretic peptide receptor|NPRB]]) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).<ref name="pmid8959763">{{cite journal | vauthors = Barr CS, Rhodes P, Struthers AD | title = C-type natriuretic peptide | journal = Peptides | volume = 17 | issue = 7 | pages = 1243–51 | year = 1996 | pmid = 8959763 | doi = 10.1016/S0196-9781(96)00110-6 }}</ref> It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO) and certain proinflammatory cytokinea.<ref name="pmid21247399">{{cite journal | vauthors = Lumsden NG, Khambata RS, Hobbs AJ | title = C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target | journal = Current Pharmaceutical Design | volume = 16 | issue = 37 | pages = 4080–8 | date = 2010 | pmid = 21247399 | pmc = 3605774 | doi = }}</ref>


[[File:C-type natriuretic peptide.png|thumb|250px|Structure of C-type natriuretic peptide (human)]]
[[File:C-type natriuretic peptide.png|thumb|250px|Structure of C-type natriuretic peptide (human)]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schulz S | title = C-type natriuretic peptide and guanylyl cyclase B receptor | journal = Peptides | volume = 26 | issue = 6 | pages = 1024–34 | date = June 2005 | pmid = 15911070 | doi = 10.1016/j.peptides.2004.08.027 }}
| citations =
* {{cite journal | vauthors = Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K | title = Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide | journal = Endocrinology | volume = 130 | issue = 1 | pages = 229–39 | date = January 1992 | pmid = 1309330 | doi = 10.1210/en.130.1.229 }}
*{{cite journal | author=Schulz S |title=C-type natriuretic peptide and guanylyl cyclase B receptor |journal=Peptides |volume=26 |issue= 6 |pages= 1024–34 |year= 2005 |pmid= 15911070 |doi= 10.1016/j.peptides.2004.08.027 }}
* {{cite journal | vauthors = Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N, Imura H | title = Human C-type natriuretic peptide. Characterization of the gene and peptide | journal = Hypertension | volume = 19 | issue = 6 Pt 2 | pages = 809–13 | date = June 1992 | pmid = 1339402 | doi = 10.1161/01.hyp.19.6.809 }}
*{{cite journal   |vauthors=Suga S, Nakao K, Hosoda K, etal |title=Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide |journal=Endocrinology |volume=130 |issue= 1 |pages= 229–39 |year= 1992 |pmid= 1309330 |doi=10.1210/en.130.1.229 }}
* {{cite journal | vauthors = Ishizaka Y, Kangawa K, Minamino N, Ishii K, Takano S, Eto T, Matsuo H | title = Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1 | journal = Biochemical and Biophysical Research Communications | volume = 189 | issue = 2 | pages = 697–704 | date = December 1992 | pmid = 1472040 | doi = 10.1016/0006-291X(92)92257-X }}
*{{cite journal   |vauthors=Ogawa Y, Nakao K, Nakagawa O, etal |title=Human C-type natriuretic peptide. Characterization of the gene and peptide |journal=Hypertension |volume=19 |issue= 6 Pt 2 |pages= 809–13 |year= 1992 |pmid= 1339402 |doi= 10.1161/01.hyp.19.6.809}}
* {{cite journal | vauthors = Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N | title = C-type natriuretic peptide (CNP) in rats and humans | journal = Endocrinology | volume = 129 | issue = 2 | pages = 1104–6 | date = August 1991 | pmid = 1855454 | doi = 10.1210/endo-129-2-1104 }}
*{{cite journal   |vauthors=Ishizaka Y, Kangawa K, Minamino N, etal |title=Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1 |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 697–704 |year= 1993 |pmid= 1472040 |doi=10.1016/0006-291X(92)92257-X }}
* {{cite journal | vauthors = Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H | title = Gene and precursor structures of human C-type natriuretic peptide | journal = Biochemical and Biophysical Research Communications | volume = 175 | issue = 2 | pages = 645–51 | date = March 1991 | pmid = 2018508 | doi = 10.1016/0006-291X(91)91614-I }}
*{{cite journal   |vauthors=Komatsu Y, Nakao K, Suga S, etal |title=C-type natriuretic peptide (CNP) in rats and humans |journal=Endocrinology |volume=129 |issue= 2 |pages= 1104–6 |year= 1991 |pmid= 1855454 |doi=10.1210/endo-129-2-1104 }}
* {{cite journal | vauthors = Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K | title = Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC) | journal = Genomics | volume = 24 | issue = 2 | pages = 383–7 | date = November 1994 | pmid = 7698765 | doi = 10.1006/geno.1994.1633 }}
*{{cite journal   |vauthors=Tawaragi Y, Fuchimura K, Tanaka S, etal |title=Gene and precursor structures of human C-type natriuretic peptide |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 2 |pages= 645–51 |year= 1991 |pmid= 2018508 |doi=10.1016/0006-291X(91)91614-I }}
* {{cite journal | vauthors = Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O | title = C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid | journal = Brain Research | volume = 612 | issue = 1-2 | pages = 104–9 | date = May 1993 | pmid = 8330189 | doi = 10.1016/0006-8993(93)91649-D }}
*{{cite journal   |vauthors=Ogawa Y, Itoh H, Yoshitake Y, etal |title=Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC) |journal=Genomics |volume=24 |issue= 2 |pages= 383–7 |year= 1995 |pmid= 7698765 |doi= 10.1006/geno.1994.1633 }}
* {{cite journal | vauthors = Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC | title = Natriuretic peptide system in human heart failure | journal = Circulation | volume = 88 | issue = 3 | pages = 1004–9 | date = September 1993 | pmid = 8353861 | doi = 10.1161/01.cir.88.3.1004 }}
*{{cite journal   |vauthors=Kaneko T, Shirakami G, Nakao K, etal |title=C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid |journal=Brain Res. |volume=612 |issue= 1–2 |pages= 104–9 |year= 1993 |pmid= 8330189 |doi=10.1016/0006-8993(93)91649-D }}
* {{cite journal | vauthors = Igaki T, Itoh H, Suga S, Komatsu Y, Ogawa Y, Doi K, Yoshimasa T, Nakao K | title = Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide | journal = Diabetes | volume = 45 Suppl 3 | issue =  | pages = S62-4 | date = July 1996 | pmid = 8674895 | doi = 10.2337/diab.45.3.s62 }}
*{{cite journal   |vauthors=Wei CM, Heublein DM, Perrella MA, etal |title=Natriuretic peptide system in human heart failure |journal=Circulation |volume=88 |issue= 3 |pages= 1004–9 |year= 1993 |pmid= 8353861 |doi= 10.1161/01.cir.88.3.1004}}
* {{cite journal | vauthors = Igaki T, Itoh H, Suga S, Hama N, Ogawa Y, Komatsu Y, Mukoyama M, Sugawara A, Yoshimasa T, Tanaka I, Nakao K | title = C-type natriuretic peptide in chronic renal failure and its action in humans | journal = Kidney International Supplement | volume = 55 | issue =  | pages = S144-7 | date = June 1996 | pmid = 8743538 | doi =  }}
*{{cite journal   |vauthors=Igaki T, Itoh H, Suga S, etal |title=Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide |journal=Diabetes |volume=45 Suppl 3 |issue=  |pages= S62–4 |year= 1996 |pmid= 8674895 |doi= 10.2337/diab.45.3.s62}}
* {{cite journal | vauthors = Vollmar AM, Paumgartner G, Gerbes AL | title = Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver | journal = Gut | volume = 40 | issue = 1 | pages = 145–50 | date = January 1997 | pmid = 9155593 | pmc = 1027025 | doi = 10.1136/gut.40.1.145 }}
*{{cite journal   |vauthors=Igaki T, Itoh H, Suga S, etal |title=C-type natriuretic peptide in chronic renal failure and its action in humans |journal=Kidney Int. Suppl. |volume=55 |issue=  |pages= S144–7 |year= 1996 |pmid= 8743538 |doi=  }}
* {{cite journal | vauthors = Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y | title = Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11 | journal = Biochemical and Molecular Medicine | volume = 61 | issue = 1 | pages = 47–51 | date = June 1997 | pmid = 9232196 | doi = 10.1006/bmme.1997.2584 }}
*{{cite journal |vauthors=Vollmar AM, Paumgartner G, Gerbes AL |title=Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver |journal=Gut |volume=40 |issue= 1 |pages= 145–50 |year= 1997 |pmid= 9155593 |doi= 10.1136/gut.40.1.145 | pmc=1027025  }}
* {{cite journal | vauthors = Martick MM, Garcia KC | title = Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone | journal = Science | volume = 293 | issue = 5535 | pages = 1657–62 | date = August 2001 | pmid = 11533490 | doi = 10.1126/science.1062246 }}
*{{cite journal |vauthors=Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y |title=Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11 |journal=Biochem. Mol. Med. |volume=61 |issue= 1 |pages= 47–51 |year= 1997 |pmid= 9232196 |doi=10.1006/bmme.1997.2584 }}
* {{cite journal | vauthors = Cataliotti A, Giordano M, De Pascale E, Giordano G, Castellino P, Jougasaki M, Costello LC, Boerrigter G, Tsuruda T, Belluardo P, Lee SC, Huntley B, Sandberg S, Malatino LS, Burnett JC | title = CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome | journal = American Journal of Physiology. Renal Physiology | volume = 283 | issue = 3 | pages = F464-72 | date = September 2002 | pmid = 12167597 | doi = 10.1152/ajprenal.00372.2001 }}
*{{cite journal |author1=He Xl |author2=Chow Dc |author3=Martick MM |author4=Garcia KC |title=Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone |journal=Science |volume=293 |issue= 5535 |pages= 1657–62 |year= 2001 |pmid= 11533490 |doi= 10.1126/science.1062246 }}
* {{cite journal | vauthors = Evans JJ, Youssef AH, Yandle TG, Lewis LK, Nicholls MG | title = Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells | journal = The Journal of Endocrinology | volume = 175 | issue = 1 | pages = 225–32 | date = October 2002 | pmid = 12379507 | doi = 10.1677/joe.0.1750225 }}
*{{cite journal   |vauthors=Cataliotti A, Giordano M, De Pascale E, etal |title=CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F464–72 |year= 2002 |pmid= 12167597 |doi= 10.1152/ajprenal.00372.2001 }}
* {{cite journal | vauthors = Ono K, Mannami T, Baba S, Tomoike H, Suga S, Iwai N | title = A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension | journal = Hypertension Research | volume = 25 | issue = 5 | pages = 727–30 | date = September 2002 | pmid = 12452325 | doi = 10.1291/hypres.25.727 }}
*{{cite journal   |vauthors=Evans JJ, Youssef AH, Yandle TG, etal |title=Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells |journal=J. Endocrinol. |volume=175 |issue= 1 |pages= 225–32 |year= 2002 |pmid= 12379507 |doi=10.1677/joe.0.1750225 }}
* {{cite journal | vauthors = Hirsch JR, Skutta N, Schlatter E | title = Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B | journal = American Journal of Physiology. Renal Physiology | volume = 285 | issue = 2 | pages = F370-4 | date = August 2003 | pmid = 12709393 | doi = 10.1152/ajprenal.00049.2003 }}
*{{cite journal   |vauthors=Ono K, Mannami T, Baba S, etal |title=A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension |journal=Hypertens. Res. |volume=25 |issue= 5 |pages= 727–30 |year= 2003 |pmid= 12452325 |doi=10.1291/hypres.25.727 }}
* {{cite journal | vauthors = Wu C, Wu F, Pan J, Morser J, Wu Q | title = Furin-mediated processing of Pro-C-type natriuretic peptide | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25847–52 | date = July 2003 | pmid = 12736257 | doi = 10.1074/jbc.M301223200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal |vauthors=Hirsch JR, Skutta N, Schlatter E |title=Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 2 |pages= F370–4 |year= 2003 |pmid= 12709393 |doi= 10.1152/ajprenal.00049.2003 }}
*{{cite journal  |vauthors=Wu C, Wu F, Pan J, etal |title=Furin-mediated processing of Pro-C-type natriuretic peptide |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25847–52 |year= 2003 |pmid= 12736257 |doi= 10.1074/jbc.M301223200 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|C-Type+Natriuretic+Peptide}}
* {{MeshName|C-Type+Natriuretic+Peptide}}
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Latest revision as of 16:12, 29 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[1][2][3] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[1] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).[4] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO) and certain proinflammatory cytokinea.[5]

File:C-type natriuretic peptide.png
Structure of C-type natriuretic peptide (human)

References

  1. ↑ 1.0 1.1 "Entrez Gene: NPPC natriuretic peptide precursor C".
  2. ↑ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  3. ↑ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  4. ↑ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.
  5. ↑ Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. PMC 3605774. PMID 21247399.

Further reading

  • Schulz S (June 2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070.
  • Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K (January 1992). "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide". Endocrinology. 130 (1): 229–39. doi:10.1210/en.130.1.229. PMID 1309330.
  • Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N, Imura H (June 1992). "Human C-type natriuretic peptide. Characterization of the gene and peptide". Hypertension. 19 (6 Pt 2): 809–13. doi:10.1161/01.hyp.19.6.809. PMID 1339402.
  • Ishizaka Y, Kangawa K, Minamino N, Ishii K, Takano S, Eto T, Matsuo H (December 1992). "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1". Biochemical and Biophysical Research Communications. 189 (2): 697–704. doi:10.1016/0006-291X(92)92257-X. PMID 1472040.
  • Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N (August 1991). "C-type natriuretic peptide (CNP) in rats and humans". Endocrinology. 129 (2): 1104–6. doi:10.1210/endo-129-2-1104. PMID 1855454.
  • Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H (March 1991). "Gene and precursor structures of human C-type natriuretic peptide". Biochemical and Biophysical Research Communications. 175 (2): 645–51. doi:10.1016/0006-291X(91)91614-I. PMID 2018508.
  • Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  • Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  • Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC (September 1993). "Natriuretic peptide system in human heart failure". Circulation. 88 (3): 1004–9. doi:10.1161/01.cir.88.3.1004. PMID 8353861.
  • Igaki T, Itoh H, Suga S, Komatsu Y, Ogawa Y, Doi K, Yoshimasa T, Nakao K (July 1996). "Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide". Diabetes. 45 Suppl 3: S62–4. doi:10.2337/diab.45.3.s62. PMID 8674895.
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