DPP10: Difference between revisions

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*{{cite journal | vauthors = Chen T, Ajami K, McCaughan GW, Gai WP, Gorrell MD, Abbott CA | title = Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity | journal = Biochim. Biophys. Acta | volume = 1764 | issue = 1 | pages = 33–43 |date=January 2006 | pmid = 16290253 | doi = 10.1016/j.bbapap.2005.09.013 }}
*{{cite journal | vauthors = Chen T, Ajami K, McCaughan GW, Gai WP, Gorrell MD, Abbott CA | title = Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity | journal = Biochim. Biophys. Acta | volume = 1764 | issue = 1 | pages = 33–43 |date=January 2006 | pmid = 16290253 | doi = 10.1016/j.bbapap.2005.09.013 }}
*{{cite journal  | vauthors=Takimoto K, Hayashi Y, Ren X, Yoshimura N |title=Species and tissue differences in the expression of DPPY splicing variants |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 3 |pages= 1094–100 |year= 2006 |pmid= 16899223 |doi= 10.1016/j.bbrc.2006.07.157 }}
*{{cite journal  | vauthors=Takimoto K, Hayashi Y, Ren X, Yoshimura N |title=Species and tissue differences in the expression of DPPY splicing variants |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 3 |pages= 1094–100 |year= 2006 |pmid= 16899223 |doi= 10.1016/j.bbrc.2006.07.157 }}
*{{cite journal  | vauthors=Jerng HH, Lauver AD, Pfaffinger PJ |title=DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels |journal=Mol. Cell. Neurosci. |volume=35 |issue= 4 |pages= 604–24 |year= 2007 |pmid= 17475505 |doi= 10.1016/j.mcn.2007.03.008 }}
*{{cite journal  | vauthors=Jerng HH, Lauver AD, Pfaffinger PJ |title=DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels |journal=Mol. Cell. Neurosci. |volume=35 |issue= 4 |pages= 604–24 |year= 2007 |pmid= 17475505 |doi= 10.1016/j.mcn.2007.03.008 |pmc=3674967 }}
*{{cite journal | vauthors = Hersh CP, Raby BA, Soto-Quirós ME, Murphy AJ, Avila L, Lasky-Su J, Sylvia JS, Klanderman BJ, Lange C, Weiss ST, Celedón JC | title = Comprehensive testing of positionally cloned asthma genes in two populations | journal = Am. J. Respir. Crit. Care Med. | volume = 176 | issue = 9 | pages = 849–57 |date=November 2007 | pmid = 17702965 | pmc = 2048676 | doi = 10.1164/rccm.200704-592OC }}
*{{cite journal | vauthors = Hersh CP, Raby BA, Soto-Quirós ME, Murphy AJ, Avila L, Lasky-Su J, Sylvia JS, Klanderman BJ, Lange C, Weiss ST, Celedón JC | title = Comprehensive testing of positionally cloned asthma genes in two populations | journal = Am. J. Respir. Crit. Care Med. | volume = 176 | issue = 9 | pages = 849–57 |date=November 2007 | pmid = 17702965 | pmc = 2048676 | doi = 10.1164/rccm.200704-592OC }}
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Latest revision as of 22:25, 15 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inactive dipeptidyl peptidase 10 is a protein that in humans is encoded by the DPP10 gene.[1][2][3] Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Function

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties.[3]

Clinical significance

Mutations in this gene have been associated with asthma[3] and autism spectrum disorders.[4]

References

  1. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  2. Qi SY, Riviere PJ, Trojnar J, Junien JL, Akinsanya KO (Jun 2003). "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases". Biochem J. 373 (Pt 1): 179–89. doi:10.1042/BJ20021914. PMC 1223468. PMID 12662155.
  3. 3.0 3.1 3.2 3.3 "Entrez Gene: DPP10 dipeptidyl-peptidase 10".
  4. Girirajan S, Dennis MY, Baker C, Malig M, Coe BP, Campbell CD, Mark K, Vu TH, Alkan C, Cheng Z, Biesecker LG, Bernier R, Eichler EE (February 2013). "Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder". Am. J. Hum. Genet. 92 (2): 221–37. doi:10.1016/j.ajhg.2012.12.016. PMC 3567267. PMID 23375656.

Further reading